| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1-phenylazo-2-naphthol 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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201 genes differentially expressed following the CRCGN014_HEPG2_24H:L17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMOX1 | heme oxygenase 1 | 8.67241 |
| ABHD4 | abhydrolase domain containing 4 | 8.10168 |
| TXNRD1 | thioredoxin reductase 1 | 6.94964 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 6.85473 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 6.73692 |
| RAP1GAP | RAP1 GTPase activating protein | 5.09913 |
| CBR1 | carbonyl reductase 1 | 5.02705 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.02199 |
| FOSL1 | FOS-like antigen 1 | 4.9991 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.89907 |
| KEAP1 | kelch-like ECH-associated protein 1 | 4.70477 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 4.70093 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.68309 |
| UBQLN2 | ubiquilin 2 | 4.49646 |
| NANOS3 | nanos homolog 3 (Drosophila) | 4.44377 |
| MAP7 | microtubule-associated protein 7 | 4.40286 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.99695 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 3.96351 |
| GPC1 | glypican 1 | 3.91921 |
| TATDN2 | TatD DNase domain containing 2 | 3.87626 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.85129 |
| SQSTM1 | sequestosome 1 | 3.8473 |
| SQOR | sulfide quinone oxidoreductase | 3.76289 |
| ZFP36 | ZFP36 ring finger protein | 3.71981 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.69109 |
| PTK2 | protein tyrosine kinase 2 | 3.6307 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.60161 |
| VAT1 | vesicle amine transport 1 | 3.58238 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.52631 |
| ANO10 | anoctamin 10 | 3.50822 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 3.4962 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 3.40623 |
| TBPL1 | TBP-like 1 | 3.36624 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.30278 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 3.26028 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.16726 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.15592 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.08609 |
| ADRB2 | adrenoceptor beta 2, surface | 3.0721 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.03408 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.99547 |
| KLHL21 | kelch-like family member 21 | 2.98406 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.97521 |
| MVP | major vault protein | 2.90058 |
| NUCB2 | nucleobindin 2 | 2.85826 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 2.81037 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.75926 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.74452 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.73049 |
| EMC3 | ER membrane protein complex subunit 3 | 2.71856 |
| STX4 | syntaxin 4 | 2.71263 |
| TRAK2 | trafficking protein, kinesin binding 2 | 2.63603 |
| TPRA1 | transmembrane protein, adipocyte asscociated 1 | 2.60094 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.59819 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.55369 |
| E2F2 | E2F transcription factor 2 | 2.52786 |
| PRKCH | protein kinase C, eta | 2.51411 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.50573 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 2.50403 |
| LOC122526780 | uncharacterized LOC122526780 | 2.46112 |
| PORCN | porcupine homolog (Drosophila) | 2.43733 |
| EIF2B2 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | 2.43002 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.41945 |
| CCDC92 | coiled-coil domain containing 92 | 2.41603 |
| PELO | pelota homolog (Drosophila) | 2.39716 |
| FPGS | folylpolyglutamate synthase | 2.37695 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 2.3442 |
| TMEM50A | transmembrane protein 50A | 2.3245 |
| UNKL | unkempt family zinc finger-like | 2.30137 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | 2.29174 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 2.27635 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.27116 |
| FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) | 2.26518 |
| TRPV4 | transient receptor potential cation channel, subfamily V, member 4 | 2.23745 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 2.22626 |
| YPEL5 | yippee-like 5 (Drosophila) | 2.20963 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.15531 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.1493 |
| PROCR | protein C receptor, endothelial | 2.14486 |
| TRIM16 | tripartite motif containing 16 | 2.1359 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | 2.12811 |
| GLRX | glutaredoxin (thioltransferase) | 2.12791 |
| LMF1 | lipase maturation factor 1 | 2.12456 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.11753 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 2.11298 |
| ADRA2C | adrenoceptor alpha 2C | 2.10768 |
| TSC1 | tuberous sclerosis 1 | 2.10288 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 2.09564 |
| RIPPLY2-CYB5R4 | RIPPLY2-CYB5R4 readthrough | 2.08359 |
| CDK18 | cyclin-dependent kinase 18 | 2.06858 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.06499 |
| BLMH | bleomycin hydrolase | 2.06165 |
| UGT1A10 | UDP glucuronosyltransferase 1 family, polypeptide A10 | 2.05063 |
| NMUR1 | neuromedin U receptor 1 | 2.04604 |
| BAD | BCL2-associated agonist of cell death | 2.03446 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.02732 |
| S1PR4 | sphingosine-1-phosphate receptor 4 | 2.01993 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.01692 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TCTN1 | tectonic family member 1 | -6.74199 |
| ISOC1 | isochorismatase domain containing 1 | -6.51219 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.29972 |
| TLR4 | toll-like receptor 4 | -5.42292 |
| MELK | maternal embryonic leucine zipper kinase | -5.03478 |
| HMGA2 | high mobility group AT-hook 2 | -4.98415 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -4.95017 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.92302 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -4.89156 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.88707 |
| CDK1 | cyclin-dependent kinase 1 | -4.77101 |
| ALDOC | aldolase C, fructose-bisphosphate | -4.71985 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.38179 |
| CCNA2 | cyclin A2 | -4.29846 |
| PLK1 | polo-like kinase 1 | -4.1111 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -4.08724 |
| CTSL | cathepsin L | -4.02237 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.92399 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.90784 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.90155 |
| CDC20 | cell division cycle 20 | -3.75733 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.75138 |
| PUF60 | poly-U binding splicing factor 60KDa | -3.70828 |
| SOAT2 | sterol O-acyltransferase 2 | -3.706 |
| DSG2 | desmoglein 2 | -3.66906 |
| HAT1 | histone acetyltransferase 1 | -3.6071 |
| GOLT1B | golgi transport 1B | -3.60571 |
| TCERG1 | transcription elongation regulator 1 | -3.59272 |
| TMEM97 | transmembrane protein 97 | -3.4988 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -3.47672 |
| AURKB | aurora kinase B | -3.44376 |
| C5 | complement component 5 | -3.43926 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -3.38448 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.33672 |
| LDHD | lactate dehydrogenase D | -3.30391 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.30378 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.23614 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -3.23471 |
| STMN1 | stathmin 1 | -3.17905 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -3.13248 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.02375 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.96923 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.92821 |
| ENOPH1 | enolase-phosphatase 1 | -2.91637 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.89493 |
| RPS5 | ribosomal protein S5 | -2.86199 |
| ZW10 | zw10 kinetochore protein | -2.82409 |
| PARP2 | poly (ADP-ribose) polymerase 2 | -2.81279 |
| ICAM3 | intercellular adhesion molecule 3 | -2.76556 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.73512 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.73487 |
| NUP85 | nucleoporin 85kDa | -2.72934 |
| INTS3 | integrator complex subunit 3 | -2.70702 |
| YME1L1 | YME1-like 1 ATPase | -2.61845 |
| GLDC | glycine dehydrogenase (decarboxylating) | -2.61036 |
| USP1 | ubiquitin specific peptidase 1 | -2.60615 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.59948 |
| PEG10 | paternally expressed 10 | -2.58144 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.56923 |
| S100A4 | S100 calcium binding protein A4 | -2.53946 |
| IER3 | immediate early response 3 | -2.51908 |
| ASF1B | anti-silencing function 1B histone chaperone | -2.51053 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -2.50869 |
| SAA4 | serum amyloid A4, constitutive | -2.4521 |
| KIF15 | kinesin family member 15 | -2.41337 |
| CCNB2 | cyclin B2 | -2.38297 |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit | -2.34433 |
| GLOD4 | glyoxalase domain containing 4 | -2.33085 |
| FBXO5 | F-box protein 5 | -2.3196 |
| PROS1 | protein S (alpha) | -2.29364 |
| AVPR1B | arginine vasopressin receptor 1B | -2.27646 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.26617 |
| TRIB3 | tribbles pseudokinase 3 | -2.25071 |
| GALE | UDP-galactose-4-epimerase | -2.24801 |
| SCRIB | scribbled planar cell polarity protein | -2.24568 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.23529 |
| EGR3 | early growth response 3 | -2.22812 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.19496 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -2.19168 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -2.18362 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -2.17905 |
| KIF4A | kinesin family member 4A | -2.16701 |
| SMC4 | structural maintenance of chromosomes 4 | -2.15387 |
| MSMO1 | methylsterol monooxygenase 1 | -2.14375 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -2.13735 |
| FGA | fibrinogen alpha chain | -2.1308 |
| COL3A1 | collagen, type III, alpha 1 | -2.11719 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -2.11018 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -2.10143 |
| UBE2NL | ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) | -2.09851 |
| COL1A2 | collagen, type I, alpha 2 | -2.09455 |
| SQLE | squalene epoxidase | -2.07404 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -2.06534 |
| FGL1 | fibrinogen-like 1 | -2.05304 |
| TYR | tyrosinase | -2.04479 |
| ICAM1 | intercellular adhesion molecule 1 | -2.04432 |
| NAV3 | neuron navigator 3 | -2.03814 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -2.0374 |
| PGM1 | phosphoglucomutase 1 | -2.03733 |
| TSPAN31 | tetraspanin 31 | -2.00729 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -2.00548 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -2.00525 |
| TLE4 | transducin-like enhancer of split 4 | -2.00445 |
