CRCGN014_HEPG2_24H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN014_HEPG2_24H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.59747
GRWD1 glutamate-rich WD repeat containing 1 5.19028
PNKP polynucleotide kinase 3'-phosphatase 4.45892
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.25641
LCN2 lipocalin 2 4.03445
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.437
CYCS cytochrome c, somatic 3.28358
NOTCH1 notch 1 3.08727
STK10 serine/threonine kinase 10 2.85389
RRAGA Ras-related GTP binding A 2.62288
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.57802
S100A4 S100 calcium binding protein A4 2.52984
AXIN1 axin 1 2.46849
ABHD6 abhydrolase domain containing 6 2.39929
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.26677
PEX11A peroxisomal biogenesis factor 11 alpha 2.18276

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -4.31949
LOC124907782 dual specificity protein phosphatase 22 -3.42988
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.39223
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.14233
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.09413
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.84681
TLR4 toll-like receptor 4 -2.79928
VAT1 vesicle amine transport 1 -2.74109
NT5DC2 5'-nucleotidase domain containing 2 -2.69956
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.67439
HYOU1 hypoxia up-regulated 1 -2.34561
FASTKD5 FAST kinase domains 5 -2.1952
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.18995