CRCGN014_HEPG2_24H:M02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triphenyl phosphate 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN014_HEPG2_24H:M02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.72012
STIMATE STIM activating enhancer 5.77588
CDC45 cell division cycle 45 3.8383
SQOR sulfide quinone oxidoreductase 3.81653
ADRB2 adrenoceptor beta 2, surface 3.33835
MINDY1 MINDY lysine 48 deubiquitinase 1 3.26258
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.21873
ATP11B ATPase, class VI, type 11B 3.20029
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.14536
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.05716
EGF epidermal growth factor 3.00808
ZFP36 ZFP36 ring finger protein 2.9457
INPP1 inositol polyphosphate-1-phosphatase 2.85538
AXIN1 axin 1 2.83516
MVP major vault protein 2.79751
VAT1 vesicle amine transport 1 2.7203
CNPY3 canopy FGF signaling regulator 3 2.70743
CCP110 centriolar coiled coil protein 110kDa 2.63811
CYCS cytochrome c, somatic 2.63561
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.52501
SQSTM1 sequestosome 1 2.45886
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.41751
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.37055
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.35596
KLHL9 kelch-like family member 9 2.28914
ITGB5 integrin, beta 5 2.27062
STAP2 signal transducing adaptor family member 2 2.25227
HDLBP high density lipoprotein binding protein 2.20248
MTERF3 mitochondrial transcription termination factor 3 2.202
NOSIP nitric oxide synthase interacting protein 2.19463
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.14098
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.10964
DDIT4 DNA-damage-inducible transcript 4 2.10655
TIMP2 TIMP metallopeptidase inhibitor 2 2.094
SCRN1 secernin 1 2.06289
TXNRD1 thioredoxin reductase 1 2.04064
NXN nucleoredoxin 2.0374
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.00583

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -6.72817
FASTKD5 FAST kinase domains 5 -5.77986
CDC20 cell division cycle 20 -5.44783
CCNB1 cyclin B1 -5.27242
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.99421
NLRP2B NLR family pyrin domain containing 2B -4.60345
CDC25B cell division cycle 25B -4.36015
CDK1 cyclin-dependent kinase 1 -4.28165
UBE2C ubiquitin-conjugating enzyme E2C -4.26509
THAP11 THAP domain containing 11 -3.84337
PCCB propionyl CoA carboxylase, beta polypeptide -3.63869
MELK maternal embryonic leucine zipper kinase -3.60074
CCNA2 cyclin A2 -3.34649
TOP2A topoisomerase (DNA) II alpha 170kDa -3.30817
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.28533
NRIP1 nuclear receptor interacting protein 1 -3.27035
PLK1 polo-like kinase 1 -3.26407
TLR4 toll-like receptor 4 -3.18725
CHMP4B charged multivesicular body protein 4B -3.15073
RFC2 replication factor C (activator 1) 2, 40kDa -3.13041
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.09169
NGRN neugrin, neurite outgrowth associated -2.94972
ARID5B AT rich interactive domain 5B (MRF1-like) -2.85892
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.81484
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.81482
HAT1 histone acetyltransferase 1 -2.7636
LDHD lactate dehydrogenase D -2.75229
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.67737
BIRC5 baculoviral IAP repeat containing 5 -2.54121
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.53483
AURKB aurora kinase B -2.52286
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.45539
ZNF83 zinc finger protein 83 -2.45129
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.40229
HAVCR1 hepatitis A virus cellular receptor 1 -2.34272
ZMIZ1 zinc finger, MIZ-type containing 1 -2.25641
ACTL7A actin-like 7A -2.22078
MRPL39 mitochondrial ribosomal protein L39 -2.21881
PSRC1 proline/serine-rich coiled-coil 1 -2.21099
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.19171
MRTFB myocardin related transcription factor B -2.16115
SNX11 sorting nexin 11 -2.15487
SMC4 structural maintenance of chromosomes 4 -2.14783
CCNF cyclin F -2.13543
SYNGR4 synaptogyrin 4 -2.1327
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.13222
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.11586
LBR lamin B receptor -2.0967
VRK1 vaccinia related kinase 1 -2.08818
SPDL1 spindle apparatus coiled-coil protein 1 -2.08762
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.08493
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.07552
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.07495
DEPDC1 DEP domain containing 1 -2.03248
TNK1 tyrosine kinase, non-receptor, 1 -2.02261
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.0224
IL33 interleukin 33 -2.01015
NUP37 nucleoporin 37kDa -2.00272
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.00248