CRCGN014_HEPG2_24H:M03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 38.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN014_HEPG2_24H:M03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.87149
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.80942
BACE2 beta-site APP-cleaving enzyme 2 3.75245
SYNE2 spectrin repeat containing, nuclear envelope 2 3.41072
STK10 serine/threonine kinase 10 3.38403
EPHB2 EPH receptor B2 3.0689
CYCS cytochrome c, somatic 2.94889
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.91527
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.7942
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.77939
UBQLN2 ubiquilin 2 2.7768
CARMIL1 capping protein regulator and myosin 1 linker 1 2.74473
GSTZ1 glutathione S-transferase zeta 1 2.64165
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.59927
CIAO3 cytosolic iron-sulfur assembly component 3 2.49022
FPGS folylpolyglutamate synthase 2.25777
LOC122526780 uncharacterized LOC122526780 2.1777
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.13211
CEMIP2 cell migration inducing hyaluronidase 2 2.06747
PRR15L proline rich 15-like 2.00739

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.02437
NT5DC2 5'-nucleotidase domain containing 2 -5.79973
TM9SF3 transmembrane 9 superfamily member 3 -4.82763
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.43546
UBE3C ubiquitin protein ligase E3C -3.38447
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.20285
GDF15 growth differentiation factor 15 -2.76901
VAT1 vesicle amine transport 1 -2.69389
RAI14 retinoic acid induced 14 -2.11248
FGFR4 fibroblast growth factor receptor 4 -2.06692
WFDC1 WAP four-disulfide core domain 1 -2.06286
RGS2 regulator of G-protein signaling 2 -2.06217