CRCGN014_HEPG2_24H:M07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN014_HEPG2_24H:M07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 6.72247
CHMP6 charged multivesicular body protein 6 5.31091
TAC4 tachykinin 4 (hemokinin) 4.83119
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.21352
SQOR sulfide quinone oxidoreductase 4.03694
NOSIP nitric oxide synthase interacting protein 3.908
PMM2 phosphomannomutase 2 3.89391
CXCL2 chemokine (C-X-C motif) ligand 2 3.70423
SATB1 SATB homeobox 1 3.59768
PLSCR1 phospholipid scramblase 1 3.35223
MAP7 microtubule-associated protein 7 3.09266
CDPF1 cysteine-rich, DPF motif domain containing 1 2.89203
DIPK1A divergent protein kinase domain 1A 2.81163
TSPAN6 tetraspanin 6 2.79068
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.67309
GARRE1 granule associated Rac and RHOG effector 1 2.48353
PRR15L proline rich 15-like 2.37186
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.36899
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.34645
PLSCR3 phospholipid scramblase 3 2.33549
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.26247
BTK Bruton agammaglobulinemia tyrosine kinase 2.21389
FZD1 frizzled class receptor 1 2.16331

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.65875
PCCB propionyl CoA carboxylase, beta polypeptide -4.97339
ZNF586 zinc finger protein 586 -4.68902
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.74531
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.32832
ZMIZ1 zinc finger, MIZ-type containing 1 -3.15336
SPAG4 sperm associated antigen 4 -3.12009
FGFR4 fibroblast growth factor receptor 4 -2.96279
SCCPDH saccharopine dehydrogenase (putative) -2.69312
CCNB2 cyclin B2 -2.69034
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.55518
TLR4 toll-like receptor 4 -2.41173
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.01888