CRCGN014_HEPG2_24H:M13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ampicillin 34.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN014_HEPG2_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.1382
SATB1 SATB homeobox 1 6.7951
LCN2 lipocalin 2 5.93215
MSRA methionine sulfoxide reductase A 5.7349
PPARG peroxisome proliferator-activated receptor gamma 4.9334
EGF epidermal growth factor 4.8921
RPL39L ribosomal protein L39-like 4.3203
TIAM1 T-cell lymphoma invasion and metastasis 1 4.0166
CYCS cytochrome c, somatic 3.94025
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.8951
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.82163
ABHD6 abhydrolase domain containing 6 3.54975
FZD7 frizzled class receptor 7 3.544
HLA-DRA major histocompatibility complex, class II, DR alpha 3.5218
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.30345
HLA-DMA major histocompatibility complex, class II, DM alpha 3.2545
GSTZ1 glutathione S-transferase zeta 1 3.25275
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.9293
TAC4 tachykinin 4 (hemokinin) 2.8794
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.80485
MAMLD1 mastermind-like domain containing 1 2.78815
PLSCR1 phospholipid scramblase 1 2.77842
CCNF cyclin F 2.5888
OXCT1 3-oxoacid CoA transferase 1 2.55855
INSIG1 insulin induced gene 1 2.54977
JADE2 jade family PHD finger 2 2.54098
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.5068
LRP10 low density lipoprotein receptor-related protein 10 2.4826
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.40702
KLHL9 kelch-like family member 9 2.37842
CSK c-src tyrosine kinase 2.31215
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.2728
BTK Bruton agammaglobulinemia tyrosine kinase 2.16785
PLBD1 phospholipase B domain containing 1 2.1071
HDAC1 histone deacetylase 1 2.08915
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.0848
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.0802
ACY1 aminoacylase 1 2.07545
EDN1 endothelin 1 2.073
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.0433
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.03585
PLPP6 phospholipid phosphatase 6 2.0258
CTSB cathepsin B 2.0175
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.0165
ASL argininosuccinate lyase 2.01435
NUSAP1 nucleolar and spindle associated protein 1 2.00518

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.491
CAB39 calcium binding protein 39 -5.0308
FBXL12 F-box and leucine-rich repeat protein 12 -5.02065
CDC20 cell division cycle 20 -4.8605
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7933
RBM34 RNA binding motif protein 34 -4.71677
LDHD lactate dehydrogenase D -4.5925
LAP3 leucine aminopeptidase 3 -4.4159
NT5DC2 5'-nucleotidase domain containing 2 -4.37185
TEX10 testis expressed 10 -3.9401
ZNF586 zinc finger protein 586 -3.6822
FCHO1 FCH domain only 1 -3.4328
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.29833
TLR4 toll-like receptor 4 -3.1343
EIF5 eukaryotic translation initiation factor 5 -3.03293
RGS2 regulator of G-protein signaling 2 -2.94755
STX4 syntaxin 4 -2.9149
NVL nuclear VCP-like -2.8637
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.83415
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.82675
RPS5 ribosomal protein S5 -2.82245
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.72682
GNAS GNAS complex locus -2.62769
RPP40 ribonuclease P/MRP 40kDa subunit -2.5651
TGFB3 transforming growth factor, beta 3 -2.5574
CCP110 centriolar coiled coil protein 110kDa -2.54845
SOAT2 sterol O-acyltransferase 2 -2.53427
FOS FBJ murine osteosarcoma viral oncogene homolog -2.53145
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.52805
TENT4A terminal nucleotidyltransferase 4A -2.51185
MARF1 meiosis regulator and mRNA stability factor 1 -2.4922
FLT4 fms-related tyrosine kinase 4 -2.48355
AIDA axin interactor, dorsalization associated -2.4576
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.4074
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.40395
GRN granulin -2.3965
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.3248
TBC1D22B TBC1 domain family, member 22B -2.32295
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.3166
FAT1 FAT atypical cadherin 1 -2.30655
AHSP alpha hemoglobin stabilizing protein -2.3005
TLCD3A TLC domain containing 3A -2.29155
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.2509
H2BC3 H2B clustered histone 3 -2.2431
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) -2.24277
FKBPL FK506 binding protein like -2.23735
DUSP21 dual specificity phosphatase 21 -2.21785
H2BC11 H2B clustered histone 11 -2.21615
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.2087
PPOX protoporphyrinogen oxidase -2.1755
POU3F2 POU class 3 homeobox 2 -2.1744
RHD Rh blood group, D antigen -2.171
ANKRD40CL ANKRD40 C-terminal like -2.15715
WRNIP1 Werner helicase interacting protein 1 -2.15245
TMEM41B transmembrane protein 41B -2.15125
PRSS16 protease, serine, 16 (thymus) -2.1496
CUX2 cut-like homeobox 2 -2.14955
ZMYM6 zinc finger, MYM-type 6 -2.12365
ASCL1 achaete-scute family bHLH transcription factor 1 -2.11701
CAPN5 calpain 5 -2.116
USP27X ubiquitin specific peptidase 27, X-linked -2.11025
GRIA3 glutamate receptor, ionotropic, AMPA 3 -2.0967
ALAS2 5'-aminolevulinate synthase 2 -2.0878
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.0851
HOXC4 homeobox C4 -2.08025
GYPE glycophorin E (MNS blood group) -2.07048
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.06965
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -2.0696
KRT85 keratin 85, type II -2.0667
CTSZ cathepsin Z -2.0588
DGKE diacylglycerol kinase, epsilon 64kDa -2.0528
KIF26B kinesin family member 26B -2.0512
MACF1 microtubule-actin crosslinking factor 1 -2.03471
AGO4 argonaute RISC catalytic component 4 -2.02525
MXD1 MAX dimerization protein 1 -2.0247
EPB42 erythrocyte membrane protein band 4.2 -2.0215
DLL3 delta-like 3 (Drosophila) -2.02075
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -2.01755
ZNF155 zinc finger protein 155 -2.0151
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.00135