CRCGN014_HEPG2_24H:N01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 20.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

181 genes differentially expressed following the CRCGN014_HEPG2_24H:N01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KCNK1 potassium channel, two pore domain subfamily K, member 1 8.15765
TIAM1 T-cell lymphoma invasion and metastasis 1 7.16993
MYLK myosin light chain kinase 6.91409
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.86144
UBQLN2 ubiquilin 2 6.35382
E2F2 E2F transcription factor 2 5.95808
ATP11B ATPase, class VI, type 11B 5.64603
CXCR4 chemokine (C-X-C motif) receptor 4 5.57369
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.09069
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 5.03663
DYNLT3 dynein, light chain, Tctex-type 3 5.03039
GSTZ1 glutathione S-transferase zeta 1 4.88374
MAP7 microtubule-associated protein 7 4.77852
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.46185
HEBP1 heme binding protein 1 4.28521
SATB1 SATB homeobox 1 4.25547
HLA-DRA major histocompatibility complex, class II, DR alpha 4.24485
BACE2 beta-site APP-cleaving enzyme 2 4.09935
JADE2 jade family PHD finger 2 3.87162
GPER1 G protein-coupled estrogen receptor 1 3.83362
CSK c-src tyrosine kinase 3.68552
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.63692
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.53919
CXCL2 chemokine (C-X-C motif) ligand 2 3.5378
SNAP25 synaptosomal-associated protein, 25kDa 3.50713
LAGE3 L antigen family, member 3 3.41126
CDPF1 cysteine-rich, DPF motif domain containing 1 3.35633
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.2404
CCL2 chemokine (C-C motif) ligand 2 3.09355
CARMIL1 capping protein regulator and myosin 1 linker 1 3.03409
CIAO3 cytosolic iron-sulfur assembly component 3 3.01097
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.00068
CCNF cyclin F 2.9318
MAMLD1 mastermind-like domain containing 1 2.93044
C2CD2 C2 calcium-dependent domain containing 2 2.91922
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.89096
NOTCH1 notch 1 2.85105
ADRB2 adrenoceptor beta 2, surface 2.82704
EPHA3 EPH receptor A3 2.82232
SFTPB surfactant protein B 2.74459
PCDHB11 protocadherin beta 11 2.73898
RPP38 ribonuclease P/MRP 38kDa subunit 2.73555
LTBP1 latent transforming growth factor beta binding protein 1 2.71809
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.71248
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.68389
PNKP polynucleotide kinase 3'-phosphatase 2.67997
ABHD6 abhydrolase domain containing 6 2.62577
CHMP6 charged multivesicular body protein 6 2.61997
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.61727
ADGRE5 adhesion G protein-coupled receptor E5 2.60273
MINDY1 MINDY lysine 48 deubiquitinase 1 2.49019
SQOR sulfide quinone oxidoreductase 2.46054
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.453
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.44904
PEX11A peroxisomal biogenesis factor 11 alpha 2.42001
SMIM40 small integral membrane protein 40 2.38178
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.3779
DNMBP dynamin binding protein 2.37677
VAV3 vav 3 guanine nucleotide exchange factor 2.36088
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.33517
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.28593
BCAS1 breast carcinoma amplified sequence 1 2.28313
IDE insulin-degrading enzyme 2.27372
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.2488
PPARG peroxisome proliferator-activated receptor gamma 2.24839
MRPL30 mitochondrial ribosomal protein L30 2.24776
MMP1 matrix metallopeptidase 1 2.24544
TBC1D3G TBC1 domain family member 3G 2.23491
GATA3 GATA binding protein 3 2.22712
MICALL1 MICAL-like 1 2.22656
TCP11L1 t-complex 11, testis-specific-like 1 2.20151
FPGS folylpolyglutamate synthase 2.19551
IL3RA interleukin 3 receptor, alpha (low affinity) 2.19188
XYLT2 xylosyltransferase II 2.15942
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.15385
MAP6D1 MAP6 domain containing 1 2.14058
BLTP3B bridge-like lipid transfer protein family member 3B 2.12817
MAGEA1 melanoma antigen family A1 2.12562
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.12489
MICA MHC class I polypeptide-related sequence A 2.12268
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.12196
AMDHD2 amidohydrolase domain containing 2 2.121
IL13 interleukin 13 2.11569
CDC45 cell division cycle 45 2.09825
BMP8B bone morphogenetic protein 8b 2.09773
FGFR3 fibroblast growth factor receptor 3 2.09452
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.08432
ANKRD49 ankyrin repeat domain 49 2.08362
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.08229
TULP4 tubby like protein 4 2.07033
CGRRF1 cell growth regulator with ring finger domain 1 2.05749
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 2.03812
LRRC42 leucine rich repeat containing 42 2.02375
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.00504
KDM5C lysine (K)-specific demethylase 5C 2.00486
EPHB2 EPH receptor B2 2.00328
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.00144

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.2862
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.16423
DSG2 desmoglein 2 -7.10172
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.93474
DUSP6 dual specificity phosphatase 6 -6.81067
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.12762
CCNB1 cyclin B1 -6.09941
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.0971
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.68268
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.58444
PCNA proliferating cell nuclear antigen -4.52184
ZMIZ1 zinc finger, MIZ-type containing 1 -4.2163
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.51102
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.4193
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.39258
GTPBP8 GTP-binding protein 8 (putative) -3.37488
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.3404
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.34032
COG7 component of oligomeric golgi complex 7 -3.29656
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.20546
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.16575
CHMP4B charged multivesicular body protein 4B -3.13928
NUP93 nucleoporin 93kDa -3.10739
NCK1 NCK adaptor protein 1 -3.10541
GOLT1B golgi transport 1B -3.08854
CDC20 cell division cycle 20 -3.01524
C2CD5 C2 calcium-dependent domain containing 5 -3.00313
TUBB6 tubulin, beta 6 class V -2.99318
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.93998
PEG10 paternally expressed 10 -2.9147
CCDC86 coiled-coil domain containing 86 -2.88708
LAP3 leucine aminopeptidase 3 -2.85185
RPIA ribose 5-phosphate isomerase A -2.81024
KDM3A lysine (K)-specific demethylase 3A -2.77482
NUP85 nucleoporin 85kDa -2.76997
HAT1 histone acetyltransferase 1 -2.76888
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.72833
MRPS2 mitochondrial ribosomal protein S2 -2.68122
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.67658
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.65284
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.61792
PLIN2 perilipin 2 -2.58879
ZDHHC6 zinc finger, DHHC-type containing 6 -2.567
PLK1 polo-like kinase 1 -2.53428
NT5DC2 5'-nucleotidase domain containing 2 -2.50651
PGAM4 phosphoglycerate mutase family member 4 -2.49528
MRPS16 mitochondrial ribosomal protein S16 -2.49
SNRPE small nuclear ribonucleoprotein polypeptide E -2.48857
PUF60 poly-U binding splicing factor 60KDa -2.4871
RGS2 regulator of G-protein signaling 2 -2.47672
PCCB propionyl CoA carboxylase, beta polypeptide -2.45314
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.44039
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.43986
ACAA1 acetyl-CoA acyltransferase 1 -2.41401
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.37419
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.35529
ARL2 ADP-ribosylation factor-like 2 -2.34991
NRIP1 nuclear receptor interacting protein 1 -2.3346
FSTL1 follistatin-like 1 -2.30867
SLC35F2 solute carrier family 35, member F2 -2.30818
IRS2 insulin receptor substrate 2 -2.30708
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.29701
UGDH UDP-glucose 6-dehydrogenase -2.26598
OXSR1 oxidative stress responsive 1 -2.2365
ADORA2B adenosine A2b receptor -2.21091
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.20389
NGRN neugrin, neurite outgrowth associated -2.20355
FN1 fibronectin 1 -2.17671
KARS1 lysyl-tRNA synthetase 1 -2.1571
JMJD6 jumonji domain containing 6 -2.14444
LYPLA1 lysophospholipase I -2.14087
EVI2B ecotropic viral integration site 2B -2.13898
LMO2 LIM domain only 2 (rhombotin-like 1) -2.13217
FCGBP Fc fragment of IgG binding protein -2.10453
GNAS GNAS complex locus -2.06335
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.05919
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.05476
CETN3 centrin, EF-hand protein, 3 -2.0503
RBM34 RNA binding motif protein 34 -2.02077
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.01869
SAP30BP SAP30 binding protein -2.00646
MT1F metallothionein 1F -2.00509
IMMT inner membrane protein, mitochondrial -2.00087