CRCGN014_HEPG2_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chloroform 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN014_HEPG2_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 6.76657
STK10 serine/threonine kinase 10 5.76222
NOTCH1 notch 1 5.30169
STIMATE STIM activating enhancer 4.87808
NOSIP nitric oxide synthase interacting protein 3.78235
ABHD6 abhydrolase domain containing 6 3.73476
GATA3 GATA binding protein 3 3.16397
TIAM1 T-cell lymphoma invasion and metastasis 1 3.0622
PPARG peroxisome proliferator-activated receptor gamma 2.99308
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.9209
BPHL biphenyl hydrolase-like (serine hydrolase) 2.91867
PRR15L proline rich 15-like 2.87603
LOC122526780 uncharacterized LOC122526780 2.75841
RNPS1 RNA binding protein S1, serine-rich domain 2.13856
LRP10 low density lipoprotein receptor-related protein 10 2.11199
GPATCH8 G patch domain containing 8 2.05371
ZNF589 zinc finger protein 589 2.04613
NKX2-2 NK2 homeobox 2 2.01869

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.17998
MRPS2 mitochondrial ribosomal protein S2 -5.17965
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.8022
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.76936
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.64122
THAP11 THAP domain containing 11 -4.59795
FGFR4 fibroblast growth factor receptor 4 -3.7754
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.54129
NRIP1 nuclear receptor interacting protein 1 -2.95766
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.74171
GNAS GNAS complex locus -2.72143
NGRN neugrin, neurite outgrowth associated -2.57633
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.33227
EIF5 eukaryotic translation initiation factor 5 -2.32177
CAB39 calcium binding protein 39 -2.23947
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.07842
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.07777
CCP110 centriolar coiled coil protein 110kDa -2.06528
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.05144