CRCGN014_HEPG2_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopyrrolidine 41.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN014_HEPG2_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EGF epidermal growth factor 6.64631
C2CD2 C2 calcium-dependent domain containing 2 4.92872
LCN2 lipocalin 2 4.84941
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.512
EPHB2 EPH receptor B2 4.26559
HOXA10 homeobox A10 4.12119
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.36142
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.13163
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.75189
ATP11B ATPase, class VI, type 11B 2.59322
NMU neuromedin U 2.59127
ADRB2 adrenoceptor beta 2, surface 2.38857
UBQLN2 ubiquilin 2 2.36192
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.30306
MED28 mediator complex subunit 28 2.25594
GPATCH8 G patch domain containing 8 2.22066
BACE2 beta-site APP-cleaving enzyme 2 2.17485
DYNLT3 dynein, light chain, Tctex-type 3 2.1377
RBBP5 retinoblastoma binding protein 5 2.1138
KIF20A kinesin family member 20A 2.0944
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.07146
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.06757

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCDC86 coiled-coil domain containing 86 -5.06792
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.8146
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.31896
TLR4 toll-like receptor 4 -4.31621
CHMP4B charged multivesicular body protein 4B -4.19384
TRIB3 tribbles pseudokinase 3 -2.89114
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.63148
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.59079
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.37974
HMG20B high mobility group 20B -2.29549
CAMTA2 calmodulin binding transcription activator 2 -2.26555
GADD45A growth arrest and DNA-damage-inducible, alpha -2.22781
PCNA proliferating cell nuclear antigen -2.17003
CASP9 caspase 9, apoptosis-related cysteine peptidase -2.15721
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.14581
DOCK2 dedicator of cytokinesis 2 -2.10162