CRCGN014_HEPG2_24H:N16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetonitrile 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN014_HEPG2_24H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.78203
MYLK myosin light chain kinase 4.5019
CDPF1 cysteine-rich, DPF motif domain containing 1 4.40441
UBQLN2 ubiquilin 2 4.33679
GSTZ1 glutathione S-transferase zeta 1 4.19315
MAP7 microtubule-associated protein 7 4.05073
GPER1 G protein-coupled estrogen receptor 1 4.00769
TIAM1 T-cell lymphoma invasion and metastasis 1 3.99569
CHN1 chimerin 1 3.57968
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.56087
ADGRE5 adhesion G protein-coupled receptor E5 3.30868
H2BC12 H2B clustered histone 12 3.10076
LPAR2 lysophosphatidic acid receptor 2 3.01685
CEMIP2 cell migration inducing hyaluronidase 2 2.84511
MOK MOK protein kinase 2.82105
EVL Enah/Vasp-like 2.75001
SATB1 SATB homeobox 1 2.60344
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.56265
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.39165
PTK2 protein tyrosine kinase 2 2.33477
HEBP1 heme binding protein 1 2.22364
DIPK1A divergent protein kinase domain 1A 2.17556
CD40 CD40 molecule, TNF receptor superfamily member 5 2.08115
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.0404
BAMBI BMP and activin membrane-bound inhibitor 2.0073

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.64157
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.37381
TLCD3A TLC domain containing 3A -3.91595
FGFR4 fibroblast growth factor receptor 4 -3.42376
GLOD4 glyoxalase domain containing 4 -3.25607
RNF167 ring finger protein 167 -3.24817
ZW10 zw10 kinetochore protein -3.1243
REEP5 receptor accessory protein 5 -2.82485
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.74233
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.44894
EGF epidermal growth factor -2.23387
CLTB clathrin, light chain B -2.08177
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.04794
TCTN1 tectonic family member 1 -2.0418