| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,4'-methylene-bis(2-chloro?aniline) 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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76 genes differentially expressed following the CRCGN014_HEPG2_24H:N17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYLK | myosin light chain kinase | 6.07535 |
| MAP7 | microtubule-associated protein 7 | 4.75661 |
| STK10 | serine/threonine kinase 10 | 3.61022 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.58975 |
| UBQLN2 | ubiquilin 2 | 3.4387 |
| TRIB3 | tribbles pseudokinase 3 | 3.21971 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.0736 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.07254 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.03926 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.99694 |
| EVL | Enah/Vasp-like | 2.94586 |
| RAB21 | RAB21, member RAS oncogene family | 2.93904 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.92253 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.91506 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 2.90141 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.88615 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.85008 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.8332 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.83167 |
| STIMATE | STIM activating enhancer | 2.82553 |
| CTSL | cathepsin L | 2.64424 |
| ABHD6 | abhydrolase domain containing 6 | 2.46061 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.45066 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.38716 |
| ABHD4 | abhydrolase domain containing 4 | 2.27057 |
| DIPK1A | divergent protein kinase domain 1A | 2.25304 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.19847 |
| SFTPB | surfactant protein B | 2.18197 |
| CDC45 | cell division cycle 45 | 2.15311 |
| CYB561 | cytochrome b561 | 2.14686 |
| NOSIP | nitric oxide synthase interacting protein | 2.11776 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 2.06558 |
| NUCB2 | nucleobindin 2 | 2.04952 |
| PRR15L | proline rich 15-like | 2.03699 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.01976 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 2.01747 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLK1 | polo-like kinase 1 | -5.76958 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.74185 |
| TLCD3A | TLC domain containing 3A | -4.65082 |
| NUP85 | nucleoporin 85kDa | -4.62824 |
| DNM1L | dynamin 1-like | -4.18561 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.04213 |
| CDK1 | cyclin-dependent kinase 1 | -3.71165 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.62964 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -3.62768 |
| MELK | maternal embryonic leucine zipper kinase | -3.61308 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.38344 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.21523 |
| LDHD | lactate dehydrogenase D | -3.19496 |
| CDC25B | cell division cycle 25B | -3.15889 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.12909 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.09432 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.036 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.93433 |
| AURKB | aurora kinase B | -2.83355 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.82537 |
| GOLT1B | golgi transport 1B | -2.74408 |
| CCNA2 | cyclin A2 | -2.60457 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.58546 |
| ICAM3 | intercellular adhesion molecule 3 | -2.5685 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -2.56416 |
| OXSR1 | oxidative stress responsive 1 | -2.5486 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.48104 |
| TCERG1 | transcription elongation regulator 1 | -2.43155 |
| CDC20 | cell division cycle 20 | -2.40653 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -2.32735 |
| HAT1 | histone acetyltransferase 1 | -2.27682 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.26453 |
| YME1L1 | YME1-like 1 ATPase | -2.22024 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.14939 |
| SLN | sarcolipin | -2.1358 |
| CDCA3 | cell division cycle associated 3 | -2.12983 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.0741 |
| RECQL4 | RecQ protein-like 4 | -2.02874 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.01102 |
| VDAC1 | voltage-dependent anion channel 1 | -2.00665 |
