CRCGN014_HEPG2_24H:N21 Gene Set
Dataset
Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category
transcriptomics
Type
small molecule perturbation
Description
disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 20.68 um perturbation at 24 h in HEPG2 (Carcinogenome )
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Genes
25 genes differentially expressed following the CRCGN014_HEPG2_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
Symbol
Name
Standardized Value
MAP3K4
mitogen-activated protein kinase kinase kinase 4
4.13966
CHN1
chimerin 1
3.66402
FZD7
frizzled class receptor 7
3.03923
VGLL4
vestigial-like family member 4
2.93044
TXNL4B
thioredoxin-like 4B
2.34357
KIF20A
kinesin family member 20A
2.31646
LCN2
lipocalin 2
2.2197
HLA-DRA
major histocompatibility complex, class II, DR alpha
2.20685
NOSIP
nitric oxide synthase interacting protein
2.16449
BIRC2
baculoviral IAP repeat containing 2
2.13602
RAB21
RAB21, member RAS oncogene family
2.10548
decreased expression
Symbol
Name
Standardized Value
LDHD
lactate dehydrogenase D
-4.87814
DNAJA3
DnaJ (Hsp40) homolog, subfamily A, member 3
-4.41972
PCNA
proliferating cell nuclear antigen
-4.07155
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
-3.3505
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
-3.29359
GNAS
GNAS complex locus
-3.0553
YME1L1
YME1-like 1 ATPase
-2.95719
RPS5
ribosomal protein S5
-2.60629
TLR4
toll-like receptor 4
-2.52108
HMG20B
high mobility group 20B
-2.45213
PDHX
pyruvate dehydrogenase complex, component X
-2.24391
DUSP13A
dual specificity phosphatase 13A
-2.04945
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
-2.04204
TM9SF2
transmembrane 9 superfamily member 2
-2.00204
