CRCGN014_HEPG2_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo-p-dioxin 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN014_HEPG2_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.3684
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.49486
UBQLN2 ubiquilin 2 4.47598
EVL Enah/Vasp-like 4.1842
SKIC8 SKI8 subunit of superkiller complex 3.49236
HEBP1 heme binding protein 1 3.42523
SKIC2 SKI2 subunit of superkiller complex 3.3508
DIPK1A divergent protein kinase domain 1A 3.34658
PPARG peroxisome proliferator-activated receptor gamma 2.84973
CCNF cyclin F 2.80904
TIAM1 T-cell lymphoma invasion and metastasis 1 2.55004
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.52394
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.4455
CHN1 chimerin 1 2.42373
BPHL biphenyl hydrolase-like (serine hydrolase) 2.32144
TPD52L2 tumor protein D52-like 2 2.20971
GPATCH8 G patch domain containing 8 2.17998
TNIP1 TNFAIP3 interacting protein 1 2.14451
NUP37 nucleoporin 37kDa 2.13931
STXBP2 syntaxin binding protein 2 2.10989
DMAP1 DNA methyltransferase 1 associated protein 1 2.08896
MEST mesoderm specific transcript 2.07068

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -5.10699
DERA deoxyribose-phosphate aldolase (putative) -4.89013
CD320 CD320 molecule -4.3944
THAP11 THAP domain containing 11 -4.1221
GNAS GNAS complex locus -3.94252
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.93781
TM9SF3 transmembrane 9 superfamily member 3 -3.85899
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.7759
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.43631
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.03667
CHIC2 cysteine-rich hydrophobic domain 2 -2.86823
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.66183
PSRC1 proline/serine-rich coiled-coil 1 -2.64098
EIF5 eukaryotic translation initiation factor 5 -2.6116
NGRN neugrin, neurite outgrowth associated -2.4998
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.42021
AFF4 AF4/FMR2 family, member 4 -2.3752
DPY19L4 dpy-19-like 4 (C. elegans) -2.21276
KLF3 Kruppel-like factor 3 (basic) -2.09372
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) -2.07692
DCHS2 dachsous cadherin-related 2 -2.01038