CRCGN014_HEPG2_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN014_HEPG2_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 8.41727
CIAO3 cytosolic iron-sulfur assembly component 3 4.55608
CHMP6 charged multivesicular body protein 6 4.25708
PMM2 phosphomannomutase 2 3.31185
DYNLT3 dynein, light chain, Tctex-type 3 3.28572
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.27054
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.13007
CYCS cytochrome c, somatic 3.10647
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.85802
ATP11B ATPase, class VI, type 11B 2.82803
CCNF cyclin F 2.76974
NMU neuromedin U 2.74432
GSTZ1 glutathione S-transferase zeta 1 2.61832
LCN2 lipocalin 2 2.4586
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.44056
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.30482

decreased expression

Symbol Name Standardized Value
C2CD5 C2 calcium-dependent domain containing 5 -4.94238
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -4.56235
CCNB2 cyclin B2 -3.79163
FBXL12 F-box and leucine-rich repeat protein 12 -3.50609
CDC20 cell division cycle 20 -3.30611
LDHD lactate dehydrogenase D -3.19126
LOC124907782 dual specificity protein phosphatase 22 -3.05476
CHMP4B charged multivesicular body protein 4B -3.03098
TLCD3A TLC domain containing 3A -2.98792
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.69143
OXA1L oxidase (cytochrome c) assembly 1-like -2.426
KCNK3 potassium channel, two pore domain subfamily K, member 3 -2.41555
NGRN neugrin, neurite outgrowth associated -2.20745
TCEA2 transcription elongation factor A (SII), 2 -2.06354
SNAP25 synaptosomal-associated protein, 25kDa -2.06244