CRCGN014_HEPG2_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN014_HEPG2_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 3.98969
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.89719
MCOLN1 mucolipin 1 3.69102
MSRA methionine sulfoxide reductase A 3.43999
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.42762
NOTCH1 notch 1 3.33441
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.33338
UBQLN2 ubiquilin 2 3.28686
LYN LYN proto-oncogene, Src family tyrosine kinase 3.21946
TENT4A terminal nucleotidyltransferase 4A 3.18309
EPN2 epsin 2 2.89922
KLHL9 kelch-like family member 9 2.72806
DIPK1A divergent protein kinase domain 1A 2.66686
CNPY3 canopy FGF signaling regulator 3 2.42791
LPAR2 lysophosphatidic acid receptor 2 2.22184
LOC122526780 uncharacterized LOC122526780 2.19871
S100A4 S100 calcium binding protein A4 2.12579
ABHD6 abhydrolase domain containing 6 2.03264
PMM2 phosphomannomutase 2 2.01201

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -6.20162
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.95286
TLR4 toll-like receptor 4 -5.32953
ZNF586 zinc finger protein 586 -3.65561
MRPS2 mitochondrial ribosomal protein S2 -3.29401
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.15266
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.09716
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.9354
MAPK13 mitogen-activated protein kinase 13 -2.70984
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.62571
GDF15 growth differentiation factor 15 -2.54221
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.47022
FGFR4 fibroblast growth factor receptor 4 -2.42624
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.39993
PCNA proliferating cell nuclear antigen -2.38533
GNAS GNAS complex locus -2.2599
HLA-DMA major histocompatibility complex, class II, DM alpha -2.20979
SLC35F2 solute carrier family 35, member F2 -2.19441
CD320 CD320 molecule -2.15736
VDAC1 voltage-dependent anion channel 1 -2.14219
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.03918
MVB12B multivesicular body subunit 12B -2.00929