CRCGN014_HEPG2_24H:O01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN014_HEPG2_24H:O01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.2934
PLS1 plastin 1 6.2213
GPER1 G protein-coupled estrogen receptor 1 5.41625
LCN2 lipocalin 2 5.40772
ABHD6 abhydrolase domain containing 6 4.91606
GATA3 GATA binding protein 3 4.81411
MAP7 microtubule-associated protein 7 4.55411
TIAM1 T-cell lymphoma invasion and metastasis 1 4.10855
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.04487
GSTZ1 glutathione S-transferase zeta 1 3.85109
FZD7 frizzled class receptor 7 3.82573
PNKP polynucleotide kinase 3'-phosphatase 3.70617
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.6319
JADE2 jade family PHD finger 2 3.58739
EGF epidermal growth factor 3.48518
C2CD2 C2 calcium-dependent domain containing 2 3.4615
ADGRE5 adhesion G protein-coupled receptor E5 3.39533
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.27545
HMOX1 heme oxygenase 1 3.26723
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.18138
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.14188
ADRB2 adrenoceptor beta 2, surface 3.08244
CCNF cyclin F 3.07317
CSK c-src tyrosine kinase 3.02889
MOK MOK protein kinase 2.99798
E2F2 E2F transcription factor 2 2.97694
H2BC12 H2B clustered histone 12 2.90453
RPP38 ribonuclease P/MRP 38kDa subunit 2.90385
CIAO3 cytosolic iron-sulfur assembly component 3 2.81185
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.75787
FPGS folylpolyglutamate synthase 2.67643
PEX11A peroxisomal biogenesis factor 11 alpha 2.6678
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.63821
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.60777
CARMIL1 capping protein regulator and myosin 1 linker 1 2.60317
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.58515
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.54502
TXNRD1 thioredoxin reductase 1 2.53014
IL23A interleukin 23, alpha subunit p19 2.52202
CYTH1 cytohesin 1 2.50945
SFTPB surfactant protein B 2.49107
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.41105
MVP major vault protein 2.3934
TBP TATA box binding protein 2.3728
MMP3 matrix metallopeptidase 3 2.36614
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.36159
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.34451
LIPC lipase, hepatic 2.33483
FBXO31 F-box protein 31 2.32262
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.27466
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.24856
PNPLA4 patatin-like phospholipase domain containing 4 2.23914
KDM5A lysine (K)-specific demethylase 5A 2.23897
FLNB filamin B, beta 2.22991
TNIP1 TNFAIP3 interacting protein 1 2.22175
STK16 serine/threonine kinase 16 2.17785
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.15551
CH25H cholesterol 25-hydroxylase 2.14828
RSU1 Ras suppressor protein 1 2.13417
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.1338
GTPBP6 GTP binding protein 6 (putative) 2.11847
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.11734
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.09471
CRY2 cryptochrome circadian clock 2 2.09411
CCKBR cholecystokinin B receptor 2.0934
GAS2 growth arrest-specific 2 2.08575
LIN7A lin-7 homolog A (C. elegans) 2.08239
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.0665
UPK3A uroplakin 3A 2.06385
IRS1 insulin receptor substrate 1 2.06285
CAB39 calcium binding protein 39 2.05761
HAS2 hyaluronan synthase 2 2.05464
CRYZ crystallin, zeta (quinone reductase) 2.0462
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.04369
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.04282
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.03582
DHDDS dehydrodolichyl diphosphate synthase 2.02833

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.97552
ZDHHC6 zinc finger, DHHC-type containing 6 -6.68729
KDM3A lysine (K)-specific demethylase 3A -6.67328
DUSP6 dual specificity phosphatase 6 -6.23277
TRIB3 tribbles pseudokinase 3 -4.20831
PCNA proliferating cell nuclear antigen -4.0427
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.93542
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -3.89141
PCCB propionyl CoA carboxylase, beta polypeptide -3.71522
NUP85 nucleoporin 85kDa -3.61339
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.60871
C2CD5 C2 calcium-dependent domain containing 5 -3.55844
TM9SF3 transmembrane 9 superfamily member 3 -3.41287
FAIM Fas apoptotic inhibitory molecule -3.26895
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.20869
LAP3 leucine aminopeptidase 3 -3.20774
TLCD3A TLC domain containing 3A -3.2068
CD320 CD320 molecule -3.20674
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.20479
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.1895
MRPS2 mitochondrial ribosomal protein S2 -3.11726
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.11266
SNX11 sorting nexin 11 -3.08642
COG7 component of oligomeric golgi complex 7 -2.96074
TOMM34 translocase of outer mitochondrial membrane 34 -2.83083
PGM1 phosphoglucomutase 1 -2.74996
RGS2 regulator of G-protein signaling 2 -2.73582
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.66929
ARID5B AT rich interactive domain 5B (MRF1-like) -2.55112
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.51278
FAM3C family with sequence similarity 3, member C -2.47795
ZNF586 zinc finger protein 586 -2.47417
CTNND1 catenin (cadherin-associated protein), delta 1 -2.36726
FMR1 fragile X mental retardation 1 -2.36026
CDHR1 cadherin-related family member 1 -2.33375
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.32177
CCDC85B coiled-coil domain containing 85B -2.30858
ISOC1 isochorismatase domain containing 1 -2.30375
TLR4 toll-like receptor 4 -2.3015
AURKB aurora kinase B -2.28262
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.25537
CYBC1 cytochrome b-245 chaperone 1 -2.18183
CEP170B centrosomal protein 170B -2.16843
TTLL12 tubulin tyrosine ligase-like family member 12 -2.16288
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.1156
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.10947
POMK protein-O-mannose kinase -2.09047
REEP5 receptor accessory protein 5 -2.07114
TMEM184B transmembrane protein 184B -2.05271
HLTF helicase-like transcription factor -2.02254