CRCGN014_HEPG2_24H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN014_HEPG2_24H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.16832
CBR3 carbonyl reductase 3 5.77742
CXCL2 chemokine (C-X-C motif) ligand 2 5.11091
VAT1 vesicle amine transport 1 4.94704
CDPF1 cysteine-rich, DPF motif domain containing 1 4.59936
PPARG peroxisome proliferator-activated receptor gamma 3.61462
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.58515
NOTCH1 notch 1 3.36976
TIMP2 TIMP metallopeptidase inhibitor 2 3.22563
CHN1 chimerin 1 3.15336
E2F2 E2F transcription factor 2 3.14933
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.1085
UBQLN2 ubiquilin 2 3.0836
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.03986
PLS1 plastin 1 2.9862
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.98448
PMM2 phosphomannomutase 2 2.97086
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.95235
MAP7 microtubule-associated protein 7 2.92981
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.9216
RPP38 ribonuclease P/MRP 38kDa subunit 2.91181
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.89622
MVP major vault protein 2.86736
STAP2 signal transducing adaptor family member 2 2.85424
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.80971
MEF2C myocyte enhancer factor 2C 2.79634
ANO1 anoctamin 1, calcium activated chloride channel 2.6812
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.66379
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.5884
CRYZ crystallin, zeta (quinone reductase) 2.56528
MYLK myosin light chain kinase 2.50753
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.48071
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.41517
TXNRD1 thioredoxin reductase 1 2.41211
CYTH1 cytohesin 1 2.40176
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.40026
NENF neudesin neurotrophic factor 2.39703
RAP1GAP RAP1 GTPase activating protein 2.37831
MINDY1 MINDY lysine 48 deubiquitinase 1 2.36436
CCDC86 coiled-coil domain containing 86 2.35173
CDC25B cell division cycle 25B 2.35083
RBMS3 RNA binding motif, single stranded interacting protein 3 2.35053
CYCS cytochrome c, somatic 2.29593
NBEAL2 neurobeachin-like 2 2.19357
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.15516
ACOT9 acyl-CoA thioesterase 9 2.14523
PLSCR1 phospholipid scramblase 1 2.08899
JUN jun proto-oncogene 2.07731
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.04542
HMOX1 heme oxygenase 1 2.02898
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.01537

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -7.00187
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.18549
FASTKD5 FAST kinase domains 5 -4.45693
MRPS2 mitochondrial ribosomal protein S2 -4.32988
ISOC1 isochorismatase domain containing 1 -4.25766
C2CD5 C2 calcium-dependent domain containing 5 -3.91804
COG2 component of oligomeric golgi complex 2 -3.66355
PCCB propionyl CoA carboxylase, beta polypeptide -3.60657
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.4747
FAIM Fas apoptotic inhibitory molecule -3.45019
PCNA proliferating cell nuclear antigen -3.38997
ZW10 zw10 kinetochore protein -3.08944
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.0312
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.00686
ARID5B AT rich interactive domain 5B (MRF1-like) -2.97309
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.89996
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.89887
FHL2 four and a half LIM domains 2 -2.67055
UGDH UDP-glucose 6-dehydrogenase -2.62999
HLA-DMA major histocompatibility complex, class II, DM alpha -2.56029
S100A4 S100 calcium binding protein A4 -2.50718
EGF epidermal growth factor -2.36099
NKG7 natural killer cell granule protein 7 -2.32435
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.31535
SLC35F2 solute carrier family 35, member F2 -2.22159
GNAS GNAS complex locus -2.21266
PSRC1 proline/serine-rich coiled-coil 1 -2.2115
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.16761
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.15622
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.09702
AURKB aurora kinase B -2.01831
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -2.01655
TMEM97 transmembrane protein 97 -2.00988