CRCGN014_HEPG2_24H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tricresyl phosphate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

168 genes differentially expressed following the CRCGN014_HEPG2_24H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.94417
CNPY3 canopy FGF signaling regulator 3 6.60491
UBQLN2 ubiquilin 2 6.32961
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.66201
LRP10 low density lipoprotein receptor-related protein 10 4.54841
TRIB3 tribbles pseudokinase 3 4.3373
SFTPB surfactant protein B 4.1717
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.09906
INPP1 inositol polyphosphate-1-phosphatase 4.0248
CBR3 carbonyl reductase 3 3.94838
MVP major vault protein 3.78573
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.73366
ATP11B ATPase, class VI, type 11B 3.59794
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.55728
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.39671
DDIT4 DNA-damage-inducible transcript 4 3.25498
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.19599
ABHD6 abhydrolase domain containing 6 3.17548
GLRX glutaredoxin (thioltransferase) 3.1532
ZFP36 ZFP36 ring finger protein 3.08371
CCDC92 coiled-coil domain containing 92 3.04967
SQSTM1 sequestosome 1 2.99843
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.98648
AMDHD2 amidohydrolase domain containing 2 2.83675
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.82814
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.7922
SEPTIN10 septin 10 2.79195
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.71959
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.66892
UFM1 ubiquitin-fold modifier 1 2.65752
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.63651
GRB10 growth factor receptor-bound protein 10 2.5949
ACOT9 acyl-CoA thioesterase 9 2.57327
MAP7 microtubule-associated protein 7 2.5698
GTPBP2 GTP binding protein 2 2.55049
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.53348
RAP1GAP RAP1 GTPase activating protein 2.52834
PRKCD protein kinase C, delta 2.52686
CHN1 chimerin 1 2.51493
NPDC1 neural proliferation, differentiation and control, 1 2.50177
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.49515
PYCR1 pyrroline-5-carboxylate reductase 1 2.49104
PNKP polynucleotide kinase 3'-phosphatase 2.4635
TIAM1 T-cell lymphoma invasion and metastasis 1 2.38863
YIPF3 Yip1 domain family, member 3 2.37847
DSG2 desmoglein 2 2.37583
TIMP2 TIMP metallopeptidase inhibitor 2 2.35419
CYCS cytochrome c, somatic 2.35084
CAMTA2 calmodulin binding transcription activator 2 2.29482
STAP2 signal transducing adaptor family member 2 2.26034
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.245
GATA3 GATA binding protein 3 2.22578
SLC67A1 solute carrier family 67 member 1 2.21038
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.18662
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.18053
FOXO4 forkhead box O4 2.17491
CAB39 calcium binding protein 39 2.15878
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.15751
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.13332
BPHL biphenyl hydrolase-like (serine hydrolase) 2.12289
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.12178
MBNL2 muscleblind-like splicing regulator 2 2.121
KIFBP kinesin family binding protein 2.11031
AARS1 alanyl-tRNA synthetase 1 2.07088
BICRAL BICRA like chromatin remodeling complex associated protein 2.05287
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.02827
RNF11 ring finger protein 11 2.02497
ITGB5 integrin, beta 5 2.02421
GHR growth hormone receptor 2.01118
SH3GL3 SH3-domain GRB2-like 3 2.00938
NPC1 Niemann-Pick disease, type C1 2.00923
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.00558
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.0055
TMEM50A transmembrane protein 50A 2.00265

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -7.099
LDHD lactate dehydrogenase D -6.87122
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.44769
UBE2C ubiquitin-conjugating enzyme E2C -6.25252
MELK maternal embryonic leucine zipper kinase -6.20357
PSRC1 proline/serine-rich coiled-coil 1 -5.97786
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.87031
PLK1 polo-like kinase 1 -5.29902
CCNB1 cyclin B1 -5.28264
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.15856
CDK1 cyclin-dependent kinase 1 -5.15034
NUP93 nucleoporin 93kDa -4.99188
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.85485
TOP2A topoisomerase (DNA) II alpha 170kDa -4.60619
HAT1 histone acetyltransferase 1 -4.48178
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.31565
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.26792
ADI1 acireductone dioxygenase 1 -4.13662
TCERG1 transcription elongation regulator 1 -4.06136
CDC25B cell division cycle 25B -4.0561
CCNA2 cyclin A2 -4.00657
TCTN1 tectonic family member 1 -3.66126
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.61141
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.32945
AURKB aurora kinase B -3.30493
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.27735
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.19832
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.13541
NGRN neugrin, neurite outgrowth associated -3.10827
CCNB2 cyclin B2 -3.05985
PGAM4 phosphoglycerate mutase family member 4 -3.01853
NUP85 nucleoporin 85kDa -2.88173
ISOC1 isochorismatase domain containing 1 -2.88166
ITGB1BP1 integrin beta 1 binding protein 1 -2.87695
BIRC5 baculoviral IAP repeat containing 5 -2.85882
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.84258
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.81665
LBR lamin B receptor -2.79582
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.77928
KIF11 kinesin family member 11 -2.75681
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.71415
STMN1 stathmin 1 -2.7003
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.69544
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.64211
ASF1B anti-silencing function 1B histone chaperone -2.62992
FANCG Fanconi anemia, complementation group G -2.52472
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.51781
CHEK2 checkpoint kinase 2 -2.48558
NFIL3 nuclear factor, interleukin 3 regulated -2.48131
FANCI Fanconi anemia, complementation group I -2.47861
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.47646
RACGAP1 Rac GTPase activating protein 1 -2.43458
NUP107 nucleoporin 107kDa -2.43295
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.40845
TLCD3A TLC domain containing 3A -2.38664
PTPRK protein tyrosine phosphatase, receptor type, K -2.38138
NCAPD2 non-SMC condensin I complex, subunit D2 -2.37924
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.36575
ERCC6L excision repair cross-complementation group 6-like -2.35658
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.32085
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.30697
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.29514
ELAC2 elaC ribonuclease Z 2 -2.29116
SPDL1 spindle apparatus coiled-coil protein 1 -2.28908
CDCA8 cell division cycle associated 8 -2.28898
KIF4A kinesin family member 4A -2.28379
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.27926
KIF14 kinesin family member 14 -2.24475
MFAP1 microfibrillar-associated protein 1 -2.21867
ZDHHC6 zinc finger, DHHC-type containing 6 -2.21105
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.21061
PTTG1 pituitary tumor-transforming 1 -2.20249
S100A4 S100 calcium binding protein A4 -2.20081
TPX2 TPX2, microtubule-associated -2.19782
DDB2 damage-specific DNA binding protein 2, 48kDa -2.18507
DNM1L dynamin 1-like -2.16972
HOXA6 homeobox A6 -2.15897
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.14859
OIP5 Opa interacting protein 5 -2.14615
DCK deoxycytidine kinase -2.11403
SNX11 sorting nexin 11 -2.10699
GTF2A2 general transcription factor IIA, 2, 12kDa -2.10458
NCAPG2 non-SMC condensin II complex, subunit G2 -2.09385
PRC1 protein regulator of cytokinesis 1 -2.08798
KIFC1 kinesin family member C1 -2.08435
THAP11 THAP domain containing 11 -2.07917
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.07687
AURKA aurora kinase A -2.05092
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.04398
RPIA ribose 5-phosphate isomerase A -2.04024
HOXA5 homeobox A5 -2.0375
TLR4 toll-like receptor 4 -2.03547
ZWINT ZW10 interacting kinetochore protein -2.02412
MRPL39 mitochondrial ribosomal protein L39 -2.01853