| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | beta-carotene 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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132 genes differentially expressed following the CRCGN014_HEPG2_24H:O05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PNKP | polynucleotide kinase 3'-phosphatase | 7.27302 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 7.18235 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 7.15382 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 6.66282 |
| MAP7 | microtubule-associated protein 7 | 5.44833 |
| EPN2 | epsin 2 | 4.67359 |
| KLHL21 | kelch-like family member 21 | 4.07493 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.01804 |
| STIMATE | STIM activating enhancer | 4.01655 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.97049 |
| LCN2 | lipocalin 2 | 3.76663 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.69017 |
| LOC122526780 | uncharacterized LOC122526780 | 3.65997 |
| LAGE3 | L antigen family, member 3 | 3.60666 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.54265 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.53472 |
| MSRA | methionine sulfoxide reductase A | 3.51549 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.46781 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.42497 |
| MYLK | myosin light chain kinase | 3.32261 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.26067 |
| NOSIP | nitric oxide synthase interacting protein | 3.2399 |
| UBQLN2 | ubiquilin 2 | 3.15988 |
| NOTCH1 | notch 1 | 3.12017 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.02381 |
| ADRB2 | adrenoceptor beta 2, surface | 2.96003 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.93125 |
| FZD7 | frizzled class receptor 7 | 2.92738 |
| STAP2 | signal transducing adaptor family member 2 | 2.84131 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.8278 |
| STK10 | serine/threonine kinase 10 | 2.73693 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | 2.72332 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.71834 |
| SATB1 | SATB homeobox 1 | 2.63086 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.60299 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.55926 |
| CHEK2 | checkpoint kinase 2 | 2.54285 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 2.50058 |
| ABHD4 | abhydrolase domain containing 4 | 2.4778 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.41337 |
| IFI35 | interferon-induced protein 35 | 2.37338 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.29088 |
| CLDN7 | claudin 7 | 2.27513 |
| TXNRD1 | thioredoxin reductase 1 | 2.25326 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 2.24765 |
| DIPK1A | divergent protein kinase domain 1A | 2.21883 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.20164 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.17997 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.17909 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 2.17803 |
| DHRS7B | dehydrogenase/reductase (SDR family) member 7B | 2.158 |
| EVL | Enah/Vasp-like | 2.15707 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.15244 |
| IFI27 | interferon, alpha-inducible protein 27 | 2.14743 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 2.13997 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 2.1305 |
| IFI6 | interferon, alpha-inducible protein 6 | 2.12584 |
| CDKN2AIP | CDKN2A interacting protein | 2.12521 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 2.12354 |
| HMOX1 | heme oxygenase 1 | 2.10526 |
| TSPAN1 | tetraspanin 1 | 2.01758 |
| JADE2 | jade family PHD finger 2 | 2.01686 |
| MCOLN1 | mucolipin 1 | 2.01257 |
| MMP9 | matrix metallopeptidase 9 | 2.00442 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MRPS2 | mitochondrial ribosomal protein S2 | -8.00858 |
| THAP11 | THAP domain containing 11 | -7.35188 |
| NUP85 | nucleoporin 85kDa | -7.15301 |
| PLK1 | polo-like kinase 1 | -7.09702 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -6.03666 |
| CHMP4B | charged multivesicular body protein 4B | -6.02352 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.95578 |
| CCDC86 | coiled-coil domain containing 86 | -4.03996 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.01806 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.95617 |
| MRPS7 | mitochondrial ribosomal protein S7 | -3.72526 |
| ISOC1 | isochorismatase domain containing 1 | -3.67691 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.59184 |
| TRIB3 | tribbles pseudokinase 3 | -3.58772 |
| LDHD | lactate dehydrogenase D | -3.38158 |
| DNM1L | dynamin 1-like | -3.33812 |
| GGA3 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3 | -3.30971 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.23898 |
| MRPL58 | mitochondrial ribosomal protein L58 | -3.19147 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.18455 |
| PEG10 | paternally expressed 10 | -3.17908 |
| ADI1 | acireductone dioxygenase 1 | -3.16628 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.15487 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.14576 |
| TLR4 | toll-like receptor 4 | -3.11069 |
| TLCD3A | TLC domain containing 3A | -3.00272 |
| LYPLA1 | lysophospholipase I | -2.96982 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.90526 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.81343 |
| SAP30BP | SAP30 binding protein | -2.76279 |
| INHBB | inhibin, beta B | -2.71573 |
| WASHC4 | WASH complex subunit 4 | -2.66922 |
| PCNA | proliferating cell nuclear antigen | -2.63987 |
| CDC25B | cell division cycle 25B | -2.60749 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -2.56076 |
| DCK | deoxycytidine kinase | -2.55776 |
| PAEP | progestagen-associated endometrial protein | -2.4872 |
| FGA | fibrinogen alpha chain | -2.46679 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.42451 |
| UTP18 | UTP18 small subunit (SSU) processome component homolog (yeast) | -2.415 |
| ATP5PD | ATP synthase peripheral stalk subunit d | -2.41413 |
| HRAS | Harvey rat sarcoma viral oncogene homolog | -2.29528 |
| CENPT | centromere protein T | -2.29292 |
| GNAS | GNAS complex locus | -2.27479 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -2.27181 |
| UCKL1 | uridine-cytidine kinase 1-like 1 | -2.26922 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -2.26462 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -2.24116 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -2.23593 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.20287 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.20234 |
| S100A4 | S100 calcium binding protein A4 | -2.17058 |
| PGLS | 6-phosphogluconolactonase | -2.16639 |
| RAB5C | RAB5C, member RAS oncogene family | -2.14965 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -2.1479 |
| RPAP1 | RNA polymerase II associated protein 1 | -2.10926 |
| USB1 | U6 snRNA biogenesis 1 | -2.10171 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -2.09651 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | -2.07469 |
| MAP1S | microtubule-associated protein 1S | -2.06125 |
| METTL9 | methyltransferase like 9 | -2.05865 |
| ZNF345 | zinc finger protein 345 | -2.03907 |
| IL37 | interleukin 37 | -2.0343 |
| EXT1 | exostosin glycosyltransferase 1 | -2.02333 |
| RNF40 | ring finger protein 40, E3 ubiquitin protein ligase | -2.02235 |
| FGB | fibrinogen beta chain | -2.02177 |
| JAK1 | Janus kinase 1 | -2.01079 |
| MMD | monocyte to macrophage differentiation-associated | -2.00326 |
