CRCGN014_HEPG2_24H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN014_HEPG2_24H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.54926
MAP7 microtubule-associated protein 7 4.91543
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.86014
NOTCH1 notch 1 4.76993
CCL2 chemokine (C-C motif) ligand 2 4.65847
SFTPB surfactant protein B 4.64861
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.39659
GPER1 G protein-coupled estrogen receptor 1 4.33736
PFKL phosphofructokinase, liver 3.51523
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.4969
PEX11A peroxisomal biogenesis factor 11 alpha 3.42662
DHDDS dehydrodolichyl diphosphate synthase 3.27325
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.13582
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.68522
NUP133 nucleoporin 133kDa 2.53868
DIPK1A divergent protein kinase domain 1A 2.52242
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.46008
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.41563
ANO1 anoctamin 1, calcium activated chloride channel 2.31737
KIF20A kinesin family member 20A 2.28505
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.27802
PEX11B peroxisomal biogenesis factor 11 beta 2.26024
BAAT bile acid CoA:amino acid N-acyltransferase 2.22686
PEX10 peroxisomal biogenesis factor 10 2.21542
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.20904
PPCS phosphopantothenoylcysteine synthetase 2.16915
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.11278
SKIC8 SKI8 subunit of superkiller complex 2.10117
EPHA3 EPH receptor A3 2.09982
SYTL2 synaptotagmin-like 2 2.02365
PEX13 peroxisomal biogenesis factor 13 2.01921
CDO1 cysteine dioxygenase type 1 2.00953
SLC30A10 solute carrier family 30, member 10 2.00518
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.00476
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.00096

decreased expression

Symbol Name Standardized Value
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -5.96734
LDHD lactate dehydrogenase D -4.91262
GTPBP8 GTP-binding protein 8 (putative) -4.89475
C2CD5 C2 calcium-dependent domain containing 5 -4.83695
CD320 CD320 molecule -4.06953
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.79693
RFC2 replication factor C (activator 1) 2, 40kDa -3.74568
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.09079
ZMIZ1 zinc finger, MIZ-type containing 1 -2.96538
RGS2 regulator of G-protein signaling 2 -2.50372
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.45644
EIF5 eukaryotic translation initiation factor 5 -2.4035
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.38726
DENND10 DENN domain containing 10 -2.30547
HSPA8 heat shock 70kDa protein 8 -2.29177
OXA1L oxidase (cytochrome c) assembly 1-like -2.28475
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.21334
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.16344
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.14453
CD163L1 CD163 molecule-like 1 -2.05632
ZNF586 zinc finger protein 586 -2.0557
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.05241
NRIP1 nuclear receptor interacting protein 1 -2.01088
CLTCL1 clathrin, heavy chain-like 1 -2.00546