CRCGN014_HEPG2_24H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description promethazine 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

301 genes differentially expressed following the CRCGN014_HEPG2_24H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate 8.2756
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.40423
NSDHL NAD(P) dependent steroid dehydrogenase-like 5.43573
GSTZ1 glutathione S-transferase zeta 1 5.34936
ELOVL6 ELOVL fatty acid elongase 6 5.20465
DDIT4 DNA-damage-inducible transcript 4 4.91833
TRIB3 tribbles pseudokinase 3 4.8064
ABHD4 abhydrolase domain containing 4 4.75843
CCDC92 coiled-coil domain containing 92 4.73221
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 4.71364
CIAO3 cytosolic iron-sulfur assembly component 3 4.64363
FAIM Fas apoptotic inhibitory molecule 4.51211
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.43498
ECH1 enoyl CoA hydratase 1, peroxisomal 4.24351
STAP2 signal transducing adaptor family member 2 4.01079
STIMATE STIM activating enhancer 4.00609
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.98575
FDFT1 farnesyl-diphosphate farnesyltransferase 1 3.9731
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.95566
RAP1GAP RAP1 GTPase activating protein 3.63756
STK10 serine/threonine kinase 10 3.56848
SHB Src homology 2 domain containing adaptor protein B 3.55405
TBC1D31 TBC1 domain family, member 31 3.5379
SCGB1D1 secretoglobin, family 1D, member 1 3.46255
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.42583
CDK7 cyclin-dependent kinase 7 3.36436
RBM15B RNA binding motif protein 15B 3.26877
ZFP36 ZFP36 ring finger protein 3.25565
GPC1 glypican 1 3.19686
H2BC12 H2B clustered histone 12 3.09097
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.06815
CXCL2 chemokine (C-X-C motif) ligand 2 3.00274
STX4 syntaxin 4 2.99832
LMBR1 limb development membrane protein 1 2.97647
MTERF3 mitochondrial transcription termination factor 3 2.95237
IFI44L interferon-induced protein 44-like 2.94509
NUPR1 nuclear protein, transcriptional regulator, 1 2.92248
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.86584
CHMP6 charged multivesicular body protein 6 2.85871
DIPK1A divergent protein kinase domain 1A 2.85556
TRAPPC6A trafficking protein particle complex 6A 2.82406
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.82261
PNPLA3 patatin-like phospholipase domain containing 3 2.81763
FOXO4 forkhead box O4 2.78412
TESK1 testis-specific kinase 1 2.75863
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.75358
PTPRK protein tyrosine phosphatase, receptor type, K 2.75094
AMDHD2 amidohydrolase domain containing 2 2.72254
ABHD6 abhydrolase domain containing 6 2.7122
IRF9 interferon regulatory factor 9 2.70835
SOAT2 sterol O-acyltransferase 2 2.64099
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.60957
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.60904
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.5832
SQLE squalene epoxidase 2.52409
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.49866
HPCA hippocalcin 2.48309
ARID4B AT rich interactive domain 4B (RBP1-like) 2.4801
COL21A1 collagen, type XXI, alpha 1 2.47688
OSGIN1 oxidative stress induced growth inhibitor 1 2.46747
CCNA1 cyclin A1 2.45705
TRIM13 tripartite motif containing 13 2.45365
DHCR24 24-dehydrocholesterol reductase 2.45261
EFCAB6 EF-hand calcium binding domain 6 2.43918
GAL3ST1 galactose-3-O-sulfotransferase 1 2.41356
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.40995
CETN2 centrin, EF-hand protein, 2 2.40931
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.39101
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.38462
ROGDI rogdi homolog (Drosophila) 2.37867
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.37105
ERBIN erbb2 interacting protein 2.36995
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.33494
VAV3 vav 3 guanine nucleotide exchange factor 2.33115
WASF3 WAS protein family, member 3 2.33109
MX1 MX dynamin-like GTPase 1 2.33024
TENT4A terminal nucleotidyltransferase 4A 2.32511
CDKL3 cyclin-dependent kinase-like 3 2.32508
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.32171
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.31553
TWF2 twinfilin actin binding protein 2 2.29265
MYLK myosin light chain kinase 2.28949
YEATS2 YEATS domain containing 2 2.28146
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.27718
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.26219
WFS1 Wolfram syndrome 1 (wolframin) 2.25414
ATP11B ATPase, class VI, type 11B 2.24106
PGAP3 post-GPI attachment to proteins 3 2.22765
ROM1 retinal outer segment membrane protein 1 2.22387
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.219
CIRSR corepressor of RBPJ and splicing regulator 2.21006
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.20977
RTN1 reticulon 1 2.20939
TRAK2 trafficking protein, kinesin binding 2 2.20322
YARS1 tyrosyl-tRNA synthetase 1 2.19105
SH3D19 SH3 domain containing 19 2.17995
KCTD5 potassium channel tetramerization domain containing 5 2.16654
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.16652
CCDC51 coiled-coil domain containing 51 2.16345
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.15025
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 2.14914
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.14764
CLCA2 chloride channel accessory 2 2.13884
INSIG2 insulin induced gene 2 2.1255
CTNND1 catenin (cadherin-associated protein), delta 1 2.12512
CCL2 chemokine (C-C motif) ligand 2 2.11786
PCLO piccolo presynaptic cytomatrix protein 2.11718
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.10801
RNF113A ring finger protein 113A 2.10657
ORM1 orosomucoid 1 2.10036
H2BC21 H2B clustered histone 21 2.0941
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.09276
TERF2IP telomeric repeat binding factor 2, interacting protein 2.08981
PHGDH phosphoglycerate dehydrogenase 2.08482
SQSTM1 sequestosome 1 2.08299
GRB7 growth factor receptor-bound protein 7 2.08274
TMCC1 transmembrane and coiled-coil domain family 1 2.07898
IFT38 intraflagellar transport 38 2.0762
HUNK hormonally up-regulated Neu-associated kinase 2.07257
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.06923
SBDS Shwachman-Bodian-Diamond syndrome 2.06141
EXT1 exostosin glycosyltransferase 1 2.05549
IFI44 interferon-induced protein 44 2.05489
ATF4 activating transcription factor 4 2.05372
PLA2G12A phospholipase A2, group XIIA 2.04908
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.04879
ADGRG1 adhesion G protein-coupled receptor G1 2.04087
SCGB2A1 secretoglobin, family 2A, member 1 2.04052
CTIF CBP80/20-dependent translation initiation factor 2.03572
PLAAT2 phospholipase A and acyltransferase 2 2.03078
TMEM165 transmembrane protein 165 2.03049
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.03005
CERT1 ceramide transporter 1 2.02563
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.02556
PLXNB3 plexin B3 2.02111
ZFYVE26 zinc finger, FYVE domain containing 26 2.01763
USP18 ubiquitin specific peptidase 18 2.01675
GRM3 glutamate receptor, metabotropic 3 2.01558

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -7.78896
GOLT1B golgi transport 1B -7.30519
PLK1 polo-like kinase 1 -7.28751
CDC20 cell division cycle 20 -6.71185
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.67465
UBE2C ubiquitin-conjugating enzyme E2C -6.41483
CD320 CD320 molecule -5.97828
CTSL cathepsin L -5.47865
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.47732
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.44266
TUBB6 tubulin, beta 6 class V -5.22449
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.01241
HAT1 histone acetyltransferase 1 -4.75977
TOP2A topoisomerase (DNA) II alpha 170kDa -4.70046
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.66349
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.02277
CDC25B cell division cycle 25B -3.96022
TCERG1 transcription elongation regulator 1 -3.92568
LDHD lactate dehydrogenase D -3.87408
PCCB propionyl CoA carboxylase, beta polypeptide -3.86729
MYCBP MYC binding protein -3.83557
CCNA2 cyclin A2 -3.79978
BIRC5 baculoviral IAP repeat containing 5 -3.73962
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.72934
PSRC1 proline/serine-rich coiled-coil 1 -3.66514
IER3 immediate early response 3 -3.52211
ZNF586 zinc finger protein 586 -3.512
ADI1 acireductone dioxygenase 1 -3.47458
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.45406
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.41137
ZDHHC6 zinc finger, DHHC-type containing 6 -3.40772
RFC2 replication factor C (activator 1) 2, 40kDa -3.35937
CDK1 cyclin-dependent kinase 1 -3.32257
S100A4 S100 calcium binding protein A4 -3.24356
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.20007
ACOT9 acyl-CoA thioesterase 9 -3.16382
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -3.13656
STMN1 stathmin 1 -3.11771
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.09352
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.07575
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.06927
DPH2 DPH2 homolog (S. cerevisiae) -3.05595
PGAM4 phosphoglycerate mutase family member 4 -3.05567
RNASE7 ribonuclease, RNase A family, 7 -3.0235
NUP85 nucleoporin 85kDa -3.01567
EXOSC9 exosome component 9 -2.9796
MELK maternal embryonic leucine zipper kinase -2.9557
CDK4 cyclin-dependent kinase 4 -2.94787
ILK integrin-linked kinase -2.94542
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.92712
SKIC2 SKI2 subunit of superkiller complex -2.92328
CDCA8 cell division cycle associated 8 -2.88658
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.87566
PARP1 poly (ADP-ribose) polymerase 1 -2.86862
EED embryonic ectoderm development -2.86423
GFUS GDP-L-fucose synthase -2.86298
GTF2A2 general transcription factor IIA, 2, 12kDa -2.85946
SPAG4 sperm associated antigen 4 -2.84909
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.84909
NLRP2B NLR family pyrin domain containing 2B -2.83106
CCNB1 cyclin B1 -2.81613
EBNA1BP2 EBNA1 binding protein 2 -2.80443
ZNF274 zinc finger protein 274 -2.77421
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.77304
RPA3 replication protein A3, 14kDa -2.76642
TSPAN4 tetraspanin 4 -2.71911
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.7069
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.69344
AXIN1 axin 1 -2.68347
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.62633
MRPL39 mitochondrial ribosomal protein L39 -2.61799
NCAPG2 non-SMC condensin II complex, subunit G2 -2.61266
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.59716
ELAVL1 ELAV like RNA binding protein 1 -2.5942
NUP93 nucleoporin 93kDa -2.5617
TP53RK TP53 regulating kinase -2.54762
BLM Bloom syndrome, RecQ helicase-like -2.54402
CRYZ crystallin, zeta (quinone reductase) -2.54205
MKI67 marker of proliferation Ki-67 -2.52625
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.52097
MRPS16 mitochondrial ribosomal protein S16 -2.52046
MRPL12 mitochondrial ribosomal protein L12 -2.50726
MCM10 minichromosome maintenance complex component 10 -2.49931
KIF14 kinesin family member 14 -2.48509
SF3A2 splicing factor 3a, subunit 2, 66kDa -2.4472
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.44151
CDCA3 cell division cycle associated 3 -2.41824
MIS18A MIS18 kinetochore protein A -2.41662
FOXM1 forkhead box M1 -2.40447
RUVBL1 RuvB-like AAA ATPase 1 -2.40002
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.3978
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.39478
RPP30 ribonuclease P/MRP 30kDa subunit -2.39145
KIFBP kinesin family binding protein -2.39096
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -2.38132
HDAC2 histone deacetylase 2 -2.36397
ASF1B anti-silencing function 1B histone chaperone -2.3556
TRIP13 thyroid hormone receptor interactor 13 -2.35384
NUP107 nucleoporin 107kDa -2.35225
TTK TTK protein kinase -2.35121
BAG2 BCL2-associated athanogene 2 -2.34614
UBE2S ubiquitin-conjugating enzyme E2S -2.34572
VDAC1 voltage-dependent anion channel 1 -2.33129
ATP5MF ATP synthase membrane subunit f -2.32008
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.31317
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.30899
STAMBP STAM binding protein -2.29679
NCAPH non-SMC condensin I complex, subunit H -2.28329
SNX11 sorting nexin 11 -2.28154
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.27294
SMNDC1 survival motor neuron domain containing 1 -2.2697
NRIP1 nuclear receptor interacting protein 1 -2.25787
MYBBP1A MYB binding protein (P160) 1a -2.25184
AURKB aurora kinase B -2.25147
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.24974
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.24846
MDC1 mediator of DNA-damage checkpoint 1 -2.24627
DDB2 damage-specific DNA binding protein 2, 48kDa -2.22231
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.20422
DCK deoxycytidine kinase -2.20277
KIFC1 kinesin family member C1 -2.20276
HEATR1 HEAT repeat containing 1 -2.20229
MAPK13 mitogen-activated protein kinase 13 -2.19573
FBXO5 F-box protein 5 -2.19178
SF3A1 splicing factor 3a, subunit 1, 120kDa -2.18826
SLIRP SRA stem-loop interacting RNA binding protein -2.18495
KIF11 kinesin family member 11 -2.18493
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.18426
SNRPF small nuclear ribonucleoprotein polypeptide F -2.18238
REEP4 receptor accessory protein 4 -2.17573
SLC35B1 solute carrier family 35, member B1 -2.16762
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.14342
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.13761
CDKN2A cyclin-dependent kinase inhibitor 2A -2.12612
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.11959
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.11949
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.11905
DMAP1 DNA methyltransferase 1 associated protein 1 -2.1171
ZNF83 zinc finger protein 83 -2.11508
FASTKD5 FAST kinase domains 5 -2.11381
RPN1 ribophorin I -2.1116
SNRPG small nuclear ribonucleoprotein polypeptide G -2.10345
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.09966
COQ3 coenzyme Q3 methyltransferase -2.09658
RPS5 ribosomal protein S5 -2.08223
CAPRIN2 caprin family member 2 -2.06511
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.05552
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.05091
PTTG1 pituitary tumor-transforming 1 -2.04586
TUBB2A tubulin, beta 2A class IIa -2.04581
NUP155 nucleoporin 155kDa -2.04486
CCNF cyclin F -2.03551
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.03333
TPX2 TPX2, microtubule-associated -2.02569
SPDL1 spindle apparatus coiled-coil protein 1 -2.01856
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.01731
TMEM126B transmembrane protein 126B -2.01541
SPTAN1 spectrin, alpha, non-erythrocytic 1 -2.01497
CENPA centromere protein A -2.01197
KIF18B kinesin family member 18B -2.01131
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.00874
RBM14-RBM4 RBM14-RBM4 readthrough -2.00556
KIF4A kinesin family member 4A -2.00475