| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3'-methyl-4-dimethylaminoazobenzene 49.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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283 genes differentially expressed following the CRCGN014_HEPG2_24H:O09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 10.0 |
| STX1A | syntaxin 1A (brain) | 6.18512 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 6.17099 |
| KLHL21 | kelch-like family member 21 | 6.05663 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 5.81624 |
| INPP1 | inositol polyphosphate-1-phosphatase | 5.65958 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.47094 |
| ANKRD10 | ankyrin repeat domain 10 | 5.46785 |
| KEAP1 | kelch-like ECH-associated protein 1 | 5.37714 |
| FOSL1 | FOS-like antigen 1 | 5.08959 |
| BLCAP | bladder cancer associated protein | 4.91992 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 4.5851 |
| TXNRD1 | thioredoxin reductase 1 | 4.46385 |
| TUBB6 | tubulin, beta 6 class V | 4.43918 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 4.35777 |
| CCNF | cyclin F | 4.3398 |
| NISCH | nischarin | 4.2929 |
| TRIB3 | tribbles pseudokinase 3 | 4.07181 |
| LCN2 | lipocalin 2 | 4.02309 |
| BZW2 | basic leucine zipper and W2 domains 2 | 3.93169 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 3.92699 |
| EGF | epidermal growth factor | 3.83656 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 3.79978 |
| CCDC92 | coiled-coil domain containing 92 | 3.74375 |
| DDIT4 | DNA-damage-inducible transcript 4 | 3.73632 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.68636 |
| ABHD4 | abhydrolase domain containing 4 | 3.63292 |
| MICALL1 | MICAL-like 1 | 3.60944 |
| TATDN2 | TatD DNase domain containing 2 | 3.6057 |
| PRAF2 | PRA1 domain family, member 2 | 3.54041 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 3.53869 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 3.5234 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 | 3.47998 |
| XPC | xeroderma pigmentosum, complementation group C | 3.47724 |
| TEX10 | testis expressed 10 | 3.46786 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.42185 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.39808 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 3.38096 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.36067 |
| RAP1GAP | RAP1 GTPase activating protein | 3.33591 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 3.26252 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.20664 |
| ADRB2 | adrenoceptor beta 2, surface | 3.18918 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 3.17969 |
| CASC3 | cancer susceptibility candidate 3 | 3.14779 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.1451 |
| CCP110 | centriolar coiled coil protein 110kDa | 3.13935 |
| ZFP36 | ZFP36 ring finger protein | 3.11051 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | 3.09762 |
| TERT | telomerase reverse transcriptase | 3.09536 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.09199 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.07466 |
| TCERG1 | transcription elongation regulator 1 | 2.99831 |
| SKIC2 | SKI2 subunit of superkiller complex | 2.94206 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.91632 |
| AEN | apoptosis enhancing nuclease | 2.90521 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.87969 |
| IL4R | interleukin 4 receptor | 2.82468 |
| SLC75A1 | solute carrier family 75 member 1 | 2.81229 |
| ZNF282 | zinc finger protein 282 | 2.79527 |
| DUSP14 | dual specificity phosphatase 14 | 2.76479 |
| PLSCR3 | phospholipid scramblase 3 | 2.7534 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.71904 |
| GPC1 | glypican 1 | 2.71522 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.71401 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.70062 |
| TPD52L2 | tumor protein D52-like 2 | 2.69929 |
| SQSTM1 | sequestosome 1 | 2.67696 |
| JADE2 | jade family PHD finger 2 | 2.668 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | 2.65396 |
| PROSER1 | proline and serine rich 1 | 2.63915 |
| GPATCH8 | G patch domain containing 8 | 2.6339 |
| UFM1 | ubiquitin-fold modifier 1 | 2.62228 |
| NPIPB5 | nuclear pore complex interacting protein family, member B5 | 2.61632 |
| DNM1L | dynamin 1-like | 2.57089 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 2.55791 |
| IER3 | immediate early response 3 | 2.5562 |
| MAP7D1 | MAP7 domain containing 1 | 2.52408 |
| MCOLN1 | mucolipin 1 | 2.51645 |
| SMNDC1 | survival motor neuron domain containing 1 | 2.51566 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.51543 |
| FNBP4 | formin binding protein 4 | 2.47643 |
| ZNF451 | zinc finger protein 451 | 2.47169 |
| CDC45 | cell division cycle 45 | 2.46374 |
| INTS6 | integrator complex subunit 6 | 2.46013 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.44543 |
| GSTM2 | glutathione S-transferase mu 2 (muscle) | 2.43452 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 2.43056 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.42229 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 2.39353 |
| CTSL | cathepsin L | 2.38598 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 2.37984 |
| HDAC7 | histone deacetylase 7 | 2.37006 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 2.36379 |
| JUN | jun proto-oncogene | 2.35224 |
| SMPD4 | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) | 2.3413 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 2.33534 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.33164 |
| EGR1 | early growth response 1 | 2.32844 |
| COL16A1 | collagen, type XVI, alpha 1 | 2.3258 |
| MRGBP | MRG/MORF4L binding protein | 2.3173 |
| CAMTA2 | calmodulin binding transcription activator 2 | 2.31709 |
| FAM193A | family with sequence similarity 193, member A | 2.2937 |
| CSRNP2 | cysteine-serine-rich nuclear protein 2 | 2.28947 |
| THSD1 | thrombospondin, type I, domain containing 1 | 2.28824 |
| ATMIN | ATM interactor | 2.28105 |
| RIN1 | Ras and Rab interactor 1 | 2.27812 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 2.27647 |
| CD2 | CD2 molecule | 2.27262 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 2.25199 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | 2.22838 |
| RRAGA | Ras-related GTP binding A | 2.21369 |
| PSPC1 | paraspeckle component 1 | 2.20566 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 2.19595 |
| TMC5 | transmembrane channel-like 5 | 2.1925 |
| PLK3 | polo-like kinase 3 | 2.19002 |
| PITPNM1 | phosphatidylinositol transfer protein, membrane-associated 1 | 2.18968 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 2.17475 |
| RNF40 | ring finger protein 40, E3 ubiquitin protein ligase | 2.16045 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.15889 |
| PILRB | paired immunoglobin-like type 2 receptor beta | 2.1576 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.14814 |
| CDK5RAP1 | CDK5 regulatory subunit associated protein 1 | 2.14768 |
| SMG5 | SMG5 nonsense mediated mRNA decay factor | 2.14264 |
| MOK | MOK protein kinase | 2.14099 |
| IFT88 | intraflagellar transport 88 | 2.13864 |
| ELAC2 | elaC ribonuclease Z 2 | 2.11925 |
| EIF6 | eukaryotic translation initiation factor 6 | 2.11353 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | 2.10478 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | 2.09476 |
| CKAP2 | cytoskeleton associated protein 2 | 2.08623 |
| CDC25B | cell division cycle 25B | 2.07958 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | 2.07114 |
| WDR6 | WD repeat domain 6 | 2.06373 |
| AAR2 | AAR2 splicing factor homolog (S. cerevisiae) | 2.05043 |
| MICALL2 | MICAL-like 2 | 2.0434 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | 2.04013 |
| DUSP6 | dual specificity phosphatase 6 | 2.03873 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 2.0323 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 2.03223 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 2.0315 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 2.02092 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 2.00805 |
| ZNF212 | zinc finger protein 212 | 2.00783 |
| PPP1R8 | protein phosphatase 1, regulatory subunit 8 | 2.00108 |
| Symbol | Name | Standardized Value |
|---|---|---|
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -6.8838 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -6.60612 |
| FGFR4 | fibroblast growth factor receptor 4 | -6.1099 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -5.61285 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.59894 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -5.44896 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -5.17691 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -5.17559 |
| RSU1 | Ras suppressor protein 1 | -5.03378 |
| PGM1 | phosphoglucomutase 1 | -4.92138 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -4.82283 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -4.59933 |
| ANO10 | anoctamin 10 | -4.40717 |
| MSRA | methionine sulfoxide reductase A | -4.29416 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.13393 |
| HMGA2 | high mobility group AT-hook 2 | -4.11923 |
| PLS1 | plastin 1 | -4.03631 |
| C5 | complement component 5 | -3.90042 |
| ADAM10 | ADAM metallopeptidase domain 10 | -3.89721 |
| SOAT2 | sterol O-acyltransferase 2 | -3.81371 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | -3.76667 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -3.73241 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -3.67457 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.5813 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.55999 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.55744 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -3.54679 |
| KLHDC2 | kelch domain containing 2 | -3.53104 |
| TCTN1 | tectonic family member 1 | -3.51855 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -3.47057 |
| LDHD | lactate dehydrogenase D | -3.3602 |
| ALDOC | aldolase C, fructose-bisphosphate | -3.35038 |
| PGK1 | phosphoglycerate kinase 1 | -3.24954 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -3.23032 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -3.22752 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.20989 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | -3.18599 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -3.18562 |
| UGDH | UDP-glucose 6-dehydrogenase | -3.13567 |
| LOC124907782 | dual specificity protein phosphatase 22 | -3.10014 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.09785 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.08079 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.06338 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -3.01894 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -3.00699 |
| CDC20 | cell division cycle 20 | -2.99112 |
| PHKB | phosphorylase kinase, beta | -2.97653 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.94189 |
| ZNF586 | zinc finger protein 586 | -2.87058 |
| BLMH | bleomycin hydrolase | -2.78664 |
| ISOC1 | isochorismatase domain containing 1 | -2.74982 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.74918 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -2.74697 |
| DENND2D | DENN/MADD domain containing 2D | -2.74617 |
| EDN1 | endothelin 1 | -2.74542 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.62652 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -2.62591 |
| GPHN | gephyrin | -2.60019 |
| USP6NL | USP6 N-terminal like | -2.59541 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.57632 |
| MYLK | myosin light chain kinase | -2.55181 |
| CER1 | cerberus 1, DAN family BMP antagonist | -2.5119 |
| RPL36AL | ribosomal protein L36a-like | -2.50125 |
| RPS5 | ribosomal protein S5 | -2.50022 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.49654 |
| L2HGDH | L-2-hydroxyglutarate dehydrogenase | -2.49275 |
| ANAPC15 | anaphase promoting complex subunit 15 | -2.48433 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -2.47547 |
| AURKB | aurora kinase B | -2.45525 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -2.44419 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -2.43303 |
| PLK1 | polo-like kinase 1 | -2.42901 |
| HAT1 | histone acetyltransferase 1 | -2.4069 |
| PROS1 | protein S (alpha) | -2.40335 |
| TRAPPC3 | trafficking protein particle complex 3 | -2.39301 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -2.38314 |
| ASGR1 | asialoglycoprotein receptor 1 | -2.37014 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.35106 |
| NUCB2 | nucleobindin 2 | -2.33824 |
| ANKRD46 | ankyrin repeat domain 46 | -2.33129 |
| HAVCR1 | hepatitis A virus cellular receptor 1 | -2.32026 |
| COMMD10 | COMM domain containing 10 | -2.30164 |
| STIMATE | STIM activating enhancer | -2.29628 |
| GAP43 | growth associated protein 43 | -2.29435 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | -2.28664 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.28372 |
| ADI1 | acireductone dioxygenase 1 | -2.27642 |
| MSMO1 | methylsterol monooxygenase 1 | -2.26864 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.26216 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.23135 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -2.23089 |
| UPB1 | ureidopropionase, beta | -2.2308 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | -2.22635 |
| INSIG1 | insulin induced gene 1 | -2.22289 |
| LBR | lamin B receptor | -2.20598 |
| MYL9 | myosin, light chain 9, regulatory | -2.19715 |
| SLC27A5 | solute carrier family 27 (fatty acid transporter), member 5 | -2.19349 |
| QPRT | quinolinate phosphoribosyltransferase | -2.19142 |
| KHK | ketohexokinase (fructokinase) | -2.18919 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.16812 |
| LYSET | lysosomal enzyme trafficking factor | -2.16579 |
| S100A4 | S100 calcium binding protein A4 | -2.16436 |
| KIF15 | kinesin family member 15 | -2.1621 |
| WDR7 | WD repeat domain 7 | -2.15745 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.15186 |
| SCGB1D1 | secretoglobin, family 1D, member 1 | -2.14651 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.13825 |
| ZIC1 | Zic family member 1 | -2.10596 |
| GLRX5 | glutaredoxin 5 | -2.09999 |
| ANOS1 | anosmin 1 | -2.09496 |
| FAM117A | family with sequence similarity 117, member A | -2.09238 |
| ECSIT | ECSIT signalling integrator | -2.09225 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.0821 |
| BCAS3 | breast carcinoma amplified sequence 3 | -2.08194 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.07137 |
| VASH2 | vasohibin 2 | -2.07104 |
| FCHSD2 | FCH and double SH3 domains 2 | -2.0615 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -2.06122 |
| NR1I3 | nuclear receptor subfamily 1, group I, member 3 | -2.05732 |
| EML1 | echinoderm microtubule associated protein like 1 | -2.05443 |
| TRDMT1 | tRNA aspartic acid methyltransferase 1 | -2.05382 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.05274 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -2.04965 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.04765 |
| TRAPPC6A | trafficking protein particle complex 6A | -2.04683 |
| CENPQ | centromere protein Q | -2.0456 |
| GDI2 | GDP dissociation inhibitor 2 | -2.04464 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -2.03667 |
| GALK1 | galactokinase 1 | -2.03646 |
| ACVR2B | activin A receptor, type IIB | -2.03571 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | -2.03135 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -2.02352 |
| LEFTY1 | left-right determination factor 1 | -2.01975 |
| ACSM2A | acyl-CoA synthetase medium-chain family member 2A | -2.01344 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -2.01084 |
| SNX11 | sorting nexin 11 | -2.00991 |
| ABHD6 | abhydrolase domain containing 6 | -2.00204 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -2.0008 |
