CRCGN014_HEPG2_24H:O11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN014_HEPG2_24H:O11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.50795
CXCL2 chemokine (C-X-C motif) ligand 2 4.71908
BZW2 basic leucine zipper and W2 domains 2 4.29349
MICALL1 MICAL-like 1 3.38379
SFTPB surfactant protein B 3.23224
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.99979
E2F2 E2F transcription factor 2 2.9208
UBQLN2 ubiquilin 2 2.80956
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.78604
H2BC12 H2B clustered histone 12 2.73067
EVL Enah/Vasp-like 2.68496
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.59189
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.44284
CCNA1 cyclin A1 2.42647
FAIM Fas apoptotic inhibitory molecule 2.37321
GPER1 G protein-coupled estrogen receptor 1 2.34947
GARRE1 granule associated Rac and RHOG effector 1 2.34361
ZFP36 ZFP36 ring finger protein 2.30979
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.22178
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.10282
FZD7 frizzled class receptor 7 2.08558

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.5484
PLK1 polo-like kinase 1 -4.36101
DNM1L dynamin 1-like -4.27351
UGDH UDP-glucose 6-dehydrogenase -4.12065
OXA1L oxidase (cytochrome c) assembly 1-like -3.15111
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.12592
CD320 CD320 molecule -2.98788
CDC20 cell division cycle 20 -2.92951
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.83908
TLR4 toll-like receptor 4 -2.79251
FBXL12 F-box and leucine-rich repeat protein 12 -2.58952
ZNF586 zinc finger protein 586 -2.56899
EIF5 eukaryotic translation initiation factor 5 -2.48448
PPOX protoporphyrinogen oxidase -2.2339
WASHC4 WASH complex subunit 4 -2.08682
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.04481