CRCGN014_HEPG2_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(4-aminobenzyl)phenylamine 20.17 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN014_HEPG2_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 4.35098
AMDHD2 amidohydrolase domain containing 2 4.2394
PLS1 plastin 1 4.23031
TREM1 triggering receptor expressed on myeloid cells 1 3.71076
PRR15L proline rich 15-like 2.85262
H2BC12 H2B clustered histone 12 2.68903
ZBTB35 zinc finger and BTB domain containing 35 2.68233
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.3327
TBXA2R thromboxane A2 receptor 2.28235
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.16021
KIF20A kinesin family member 20A 2.10135
HLA-DRA major histocompatibility complex, class II, DR alpha 2.02635
CHN1 chimerin 1 2.01423

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -5.92371
ZNF586 zinc finger protein 586 -5.6219
PCNA proliferating cell nuclear antigen -5.57284
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.34672
DNM1L dynamin 1-like -4.08964
LDHD lactate dehydrogenase D -4.00113
ZMIZ1 zinc finger, MIZ-type containing 1 -3.91677
GOLT1B golgi transport 1B -3.83665
TLR4 toll-like receptor 4 -3.18023
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.67937
LRRC41 leucine rich repeat containing 41 -2.58194
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.42214
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.33363
CST4 cystatin S -2.14431