CRCGN014_HEPG2_24H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoin 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN014_HEPG2_24H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.96409
CIAO3 cytosolic iron-sulfur assembly component 3 4.8805
PPARG peroxisome proliferator-activated receptor gamma 4.55799
DHDDS dehydrodolichyl diphosphate synthase 4.44399
SMIM40 small integral membrane protein 40 4.09694
PEX11A peroxisomal biogenesis factor 11 alpha 3.74349
EPN2 epsin 2 3.69943
SQOR sulfide quinone oxidoreductase 3.55161
DENND2D DENN/MADD domain containing 2D 3.38125
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.03503
LEP leptin 3.01703
MAP7 microtubule-associated protein 7 2.97393
GSTZ1 glutathione S-transferase zeta 1 2.89917
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.8106
NMU neuromedin U 2.78189
SAMD14 sterile alpha motif domain containing 14 2.7816
KCNIP2 Kv channel interacting protein 2 2.74045
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.45965
KRT3 keratin 3, type II 2.43604
MEGF8 multiple EGF-like-domains 8 2.4271
MUS81 MUS81 structure-specific endonuclease subunit 2.41932
MSI1 musashi RNA-binding protein 1 2.35635
GNA12 guanine nucleotide binding protein (G protein) alpha 12 2.34147
CIDEA cell death-inducing DFFA-like effector a 2.32857
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.31441
VPS9D1 VPS9 domain containing 1 2.28062
MAOA monoamine oxidase A 2.21438
SSB Sjogren syndrome antigen B (autoantigen La) 2.20712
ZBTB16 zinc finger and BTB domain containing 16 2.20255
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.18448
KIF20A kinesin family member 20A 2.17886
NPR1 natriuretic peptide receptor 1 2.15647
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.13206
TRIM9 tripartite motif containing 9 2.12798
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.10238
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.07332
AQP7 aquaporin 7 2.06774
FNDC4 fibronectin type III domain containing 4 2.05198
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.03534
LIPE lipase, hormone-sensitive 2.02703
TIMP4 TIMP metallopeptidase inhibitor 4 2.02095
VWA5A von Willebrand factor A domain containing 5A 2.01995
SYP synaptophysin 2.01641
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.0162
HAMP hepcidin antimicrobial peptide 2.00556
SPAG16 sperm associated antigen 16 2.00003

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -8.78073
YME1L1 YME1-like 1 ATPase -6.28976
SCAND1 SCAN domain containing 1 -5.42251
KDM3A lysine (K)-specific demethylase 3A -5.38775
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.97069
ZDHHC6 zinc finger, DHHC-type containing 6 -3.91396
TLR4 toll-like receptor 4 -3.78496
RPS5 ribosomal protein S5 -3.50171
FGFR4 fibroblast growth factor receptor 4 -3.37798
LDHD lactate dehydrogenase D -3.21929
MTPAP mitochondrial poly(A) polymerase -2.96957
MACF1 microtubule-actin crosslinking factor 1 -2.84222
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.81328
RFC2 replication factor C (activator 1) 2, 40kDa -2.79319
SEC16A SEC16 homolog A (S. cerevisiae) -2.7621
PAEP progestagen-associated endometrial protein -2.51369
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.47583
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.45159
PMPCA peptidase (mitochondrial processing) alpha -2.43589
SACS sacsin molecular chaperone -2.37612
CPNE3 copine III -2.34921
CD58 CD58 molecule -2.32157
WAC WW domain containing adaptor with coiled-coil -2.266
PECR peroxisomal trans-2-enoyl-CoA reductase -2.24757
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.16543
GADD45G growth arrest and DNA-damage-inducible, gamma -2.15907
KLK11 kallikrein-related peptidase 11 -2.01178
NELFB negative elongation factor complex member B -2.00207