CRCGN014_HEPG2_24H:O18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 21.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_24H:O18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 8.88281
BACE2 beta-site APP-cleaving enzyme 2 8.61557
GPER1 G protein-coupled estrogen receptor 1 5.84178
PNKP polynucleotide kinase 3'-phosphatase 5.08114
EGF epidermal growth factor 4.77425
E2F2 E2F transcription factor 2 4.50909
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.32594
EAPP E2F-associated phosphoprotein 3.80644
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.76477
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.73717
HDGFL3 HDGF like 3 3.62033
ANO1 anoctamin 1, calcium activated chloride channel 3.30902
MAP7 microtubule-associated protein 7 3.05078
CYCS cytochrome c, somatic 2.84913
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.84737
SOCS2 suppressor of cytokine signaling 2 2.35436
MX1 MX dynamin-like GTPase 1 2.28616
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.2068
HEBP1 heme binding protein 1 2.16557
CGRRF1 cell growth regulator with ring finger domain 1 2.08854
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.05735
HOXA5 homeobox A5 2.04775
TPD52L2 tumor protein D52-like 2 2.04691
JADE2 jade family PHD finger 2 2.04476
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.03496
ISG15 ISG15 ubiquitin-like modifier 2.02373

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.24566
TSPAN4 tetraspanin 4 -5.09639
KDM3A lysine (K)-specific demethylase 3A -4.84521
GTPBP8 GTP-binding protein 8 (putative) -4.09753
PCNA proliferating cell nuclear antigen -3.93653
ZMIZ1 zinc finger, MIZ-type containing 1 -3.58387
CD58 CD58 molecule -3.36081
CCNB2 cyclin B2 -2.82616
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.48519
RBM34 RNA binding motif protein 34 -2.07371
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.04618
SNX11 sorting nexin 11 -2.03429