| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | phenyl-b-naphthylamine 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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69 genes differentially expressed following the CRCGN014_HEPG2_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 6.87306 |
| SQOR | sulfide quinone oxidoreductase | 4.46513 |
| ABHD4 | abhydrolase domain containing 4 | 4.33095 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.03029 |
| CBR3 | carbonyl reductase 3 | 3.78887 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.7182 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.63452 |
| UBQLN2 | ubiquilin 2 | 3.54729 |
| TXNRD1 | thioredoxin reductase 1 | 3.41829 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.35738 |
| CNPY3 | canopy FGF signaling regulator 3 | 3.18198 |
| CHN1 | chimerin 1 | 3.10626 |
| VAT1 | vesicle amine transport 1 | 3.05109 |
| RAP1GAP | RAP1 GTPase activating protein | 2.95651 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.94624 |
| LCN2 | lipocalin 2 | 2.93069 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.82677 |
| MAP7 | microtubule-associated protein 7 | 2.68169 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.54462 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.53594 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.4302 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.42136 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.40627 |
| CTSL | cathepsin L | 2.38712 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.27752 |
| SQSTM1 | sequestosome 1 | 2.26143 |
| RRAGA | Ras-related GTP binding A | 2.21111 |
| HMOX1 | heme oxygenase 1 | 2.18289 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.16504 |
| CISD1 | CDGSH iron sulfur domain 1 | 2.16376 |
| ZFP36 | ZFP36 ring finger protein | 2.14893 |
| HOXA10 | homeobox A10 | 2.14428 |
| GLRX | glutaredoxin (thioltransferase) | 2.14166 |
| STAP2 | signal transducing adaptor family member 2 | 2.1018 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.04836 |
| MEST | mesoderm specific transcript | 2.02925 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.02818 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.02793 |
| DENND2D | DENN/MADD domain containing 2D | 2.01874 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TLCD3A | TLC domain containing 3A | -5.2969 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -4.97455 |
| PCNA | proliferating cell nuclear antigen | -4.73786 |
| GNAS | GNAS complex locus | -4.33992 |
| CDC20 | cell division cycle 20 | -3.97627 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.92357 |
| PEG10 | paternally expressed 10 | -3.73436 |
| COG7 | component of oligomeric golgi complex 7 | -3.68622 |
| SMNDC1 | survival motor neuron domain containing 1 | -3.66404 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -3.60521 |
| LDHD | lactate dehydrogenase D | -3.56009 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.54754 |
| TUBB6 | tubulin, beta 6 class V | -3.26507 |
| SPAG4 | sperm associated antigen 4 | -3.24673 |
| ACOT9 | acyl-CoA thioesterase 9 | -3.20248 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.1501 |
| CCNB1 | cyclin B1 | -3.07348 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.88303 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.86851 |
| CCDC86 | coiled-coil domain containing 86 | -2.83893 |
| TP53BP2 | tumor protein p53 binding protein 2 | -2.73498 |
| ZNF586 | zinc finger protein 586 | -2.59601 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.38535 |
| VDAC1 | voltage-dependent anion channel 1 | -2.34181 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.33279 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.21874 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.13278 |
| ZNF721 | zinc finger protein 721 | -2.10461 |
| COPS7A | COP9 signalosome subunit 7A | -2.08679 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -2.0077 |
