CRCGN014_HEPG2_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 21.42 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

122 genes differentially expressed following the CRCGN014_HEPG2_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 6.94872
STIMATE STIM activating enhancer 4.73232
INPP1 inositol polyphosphate-1-phosphatase 4.53741
C2CD2 C2 calcium-dependent domain containing 2 4.18844
TXNRD1 thioredoxin reductase 1 3.79504
PPARG peroxisome proliferator-activated receptor gamma 3.78469
SQOR sulfide quinone oxidoreductase 3.72864
PRKCQ protein kinase C, theta 3.67616
TIMP2 TIMP metallopeptidase inhibitor 2 3.64007
UBQLN2 ubiquilin 2 3.50595
LCN2 lipocalin 2 3.45464
TRIB3 tribbles pseudokinase 3 3.38179
STX1A syntaxin 1A (brain) 3.34774
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.27866
GLRX glutaredoxin (thioltransferase) 3.26689
NPDC1 neural proliferation, differentiation and control, 1 3.2535
SKIC8 SKI8 subunit of superkiller complex 3.14685
NANOS3 nanos homolog 3 (Drosophila) 3.10975
ZFP36 ZFP36 ring finger protein 3.05528
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.99339
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.87357
CDC45 cell division cycle 45 2.83606
SLC35F2 solute carrier family 35, member F2 2.8323
NUCB2 nucleobindin 2 2.78605
LRP10 low density lipoprotein receptor-related protein 10 2.68919
IL4R interleukin 4 receptor 2.6758
SFTPB surfactant protein B 2.60216
EGR1 early growth response 1 2.58634
ABHD4 abhydrolase domain containing 4 2.57221
TOMM34 translocase of outer mitochondrial membrane 34 2.56795
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.5465
CFLAR CASP8 and FADD-like apoptosis regulator 2.54057
PRR15L proline rich 15-like 2.5292
KIFBP kinesin family binding protein 2.49105
MVP major vault protein 2.42561
UGDH UDP-glucose 6-dehydrogenase 2.41868
TRIB1 tribbles pseudokinase 1 2.39584
MFSD1 major facilitator superfamily domain containing 1 2.35712
YIPF3 Yip1 domain family, member 3 2.33478
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.31903
CDPF1 cysteine-rich, DPF motif domain containing 1 2.31008
SQSTM1 sequestosome 1 2.29123
FOSL1 FOS-like antigen 1 2.27896
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.26693
S100A13 S100 calcium binding protein A13 2.26229
FPGS folylpolyglutamate synthase 2.26104
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.2475
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.23011
TASL TLR adaptor interacting with endolysosomal SLC15A4 2.21575
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.19756
TM9SF3 transmembrane 9 superfamily member 3 2.18484
MAPK13 mitogen-activated protein kinase 13 2.17159
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.14024
DNM1 dynamin 1 2.11469
CLEC11A C-type lectin domain family 11, member A 2.07188
VAT1 vesicle amine transport 1 2.03788
ADGRE5 adhesion G protein-coupled receptor E5 2.03092

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.69352
ISOC1 isochorismatase domain containing 1 -5.8893
CCNA2 cyclin A2 -4.37679
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.35143
CDC25B cell division cycle 25B -4.10625
FBXL12 F-box and leucine-rich repeat protein 12 -4.07828
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.02459
BIRC5 baculoviral IAP repeat containing 5 -3.90514
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.89496
CDK1 cyclin-dependent kinase 1 -3.81849
MELK maternal embryonic leucine zipper kinase -3.79847
TCTN1 tectonic family member 1 -3.75976
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.69604
AURKB aurora kinase B -3.67304
TOP2A topoisomerase (DNA) II alpha 170kDa -3.55241
PSRC1 proline/serine-rich coiled-coil 1 -3.55073
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.53654
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.39926
CDC20 cell division cycle 20 -3.23266
PECR peroxisomal trans-2-enoyl-CoA reductase -3.22681
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.22236
PLK1 polo-like kinase 1 -3.14749
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.09046
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.94048
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.91708
UBE2C ubiquitin-conjugating enzyme E2C -2.91338
HADH hydroxyacyl-CoA dehydrogenase -2.70277
MRPS2 mitochondrial ribosomal protein S2 -2.67795
VDAC1 voltage-dependent anion channel 1 -2.67484
NCAPD2 non-SMC condensin I complex, subunit D2 -2.63657
PGRMC1 progesterone receptor membrane component 1 -2.63516
FGFR4 fibroblast growth factor receptor 4 -2.59492
MYL9 myosin, light chain 9, regulatory -2.56912
LBR lamin B receptor -2.56329
ASF1B anti-silencing function 1B histone chaperone -2.54881
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.5195
PDZD2 PDZ domain containing 2 -2.51513
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.51413
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.45146
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.44876
EGF epidermal growth factor -2.43497
TK1 thymidine kinase 1, soluble -2.42332
ACAA1 acetyl-CoA acyltransferase 1 -2.37853
VRK1 vaccinia related kinase 1 -2.35152
HSPB1 heat shock 27kDa protein 1 -2.28735
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.26723
HAT1 histone acetyltransferase 1 -2.25704
CHEK2 checkpoint kinase 2 -2.25636
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -2.25391
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.25254
SOAT2 sterol O-acyltransferase 2 -2.24881
RNF167 ring finger protein 167 -2.24085
CCNB1 cyclin B1 -2.22551
FBXO5 F-box protein 5 -2.19838
ERCC6L excision repair cross-complementation group 6-like -2.16891
DEPDC1 DEP domain containing 1 -2.15107
WEE1 WEE1 G2 checkpoint kinase -2.12893
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.09642
ICAM3 intercellular adhesion molecule 3 -2.07154
HYOU1 hypoxia up-regulated 1 -2.06984
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.0683
DIABLO diablo, IAP-binding mitochondrial protein -2.06527
CDC6 cell division cycle 6 -2.0565
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.04059
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.02518