CRCGN014_HEPG2_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.01 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN014_HEPG2_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 6.79763
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.6294
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.46044
LYN LYN proto-oncogene, Src family tyrosine kinase 5.58445
CRYZ crystallin, zeta (quinone reductase) 4.4547
TIAM1 T-cell lymphoma invasion and metastasis 1 4.34
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.91541
TXNRD1 thioredoxin reductase 1 3.42665
SORBS3 sorbin and SH3 domain containing 3 3.39789
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.33301
GPER1 G protein-coupled estrogen receptor 1 3.10717
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.09296
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.04637
RAP1GAP RAP1 GTPase activating protein 3.013
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.96409
HMOX1 heme oxygenase 1 2.92835
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.82143
RSU1 Ras suppressor protein 1 2.81647
STAP2 signal transducing adaptor family member 2 2.81349
LOC122526780 uncharacterized LOC122526780 2.80704
MVP major vault protein 2.80273
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.7762
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.73366
CHN1 chimerin 1 2.67279
ACOT9 acyl-CoA thioesterase 9 2.63414
SQOR sulfide quinone oxidoreductase 2.59024
RPP38 ribonuclease P/MRP 38kDa subunit 2.57413
PFKL phosphofructokinase, liver 2.52654
CYTH1 cytohesin 1 2.50468
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.42724
PLS1 plastin 1 2.41319
CNPY3 canopy FGF signaling regulator 3 2.37696
CDC25B cell division cycle 25B 2.3264
FPGS folylpolyglutamate synthase 2.29426
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.28115
BMP4 bone morphogenetic protein 4 2.22171
HMG20B high mobility group 20B 2.21984
UGDH UDP-glucose 6-dehydrogenase 2.20658
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.19843
CGRRF1 cell growth regulator with ring finger domain 1 2.12715
TRADD TNFRSF1A-associated via death domain 2.07554
DUSP6 dual specificity phosphatase 6 2.02675
PUDP pseudouridine 5'-phosphatase 2.00539

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -4.56147
PLK1 polo-like kinase 1 -4.32621
CDC20 cell division cycle 20 -3.99924
FHL2 four and a half LIM domains 2 -3.96196
SLC35F2 solute carrier family 35, member F2 -3.62026
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.59422
NUP85 nucleoporin 85kDa -3.58472
NCK1 NCK adaptor protein 1 -3.43754
PSRC1 proline/serine-rich coiled-coil 1 -3.22895
RNF167 ring finger protein 167 -3.15658
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.06196
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.8599
DDIT4 DNA-damage-inducible transcript 4 -2.67209
CCDC86 coiled-coil domain containing 86 -2.51234
TLR4 toll-like receptor 4 -2.50487
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.48695
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.48271
ZMIZ1 zinc finger, MIZ-type containing 1 -2.40131
C5 complement component 5 -2.35304
HYOU1 hypoxia up-regulated 1 -2.32299
AURKB aurora kinase B -2.28918
ISOC1 isochorismatase domain containing 1 -2.16546
MAPK13 mitogen-activated protein kinase 13 -2.12951
AMDHD2 amidohydrolase domain containing 2 -2.1028
ALDOC aldolase C, fructose-bisphosphate -2.09172
CHKA choline kinase alpha -2.07996
CDC37L1 cell division cycle 37-like 1 -2.00151