| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disulfiram 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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290 genes differentially expressed following the CRCGN014_HEPG2_24H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 7.15536 |
| CNPY3 | canopy FGF signaling regulator 3 | 6.14024 |
| HSPA1A | heat shock 70kDa protein 1A | 5.69693 |
| TUBB6 | tubulin, beta 6 class V | 5.23231 |
| FOSL1 | FOS-like antigen 1 | 4.63396 |
| SQOR | sulfide quinone oxidoreductase | 4.53618 |
| LCN2 | lipocalin 2 | 4.45271 |
| GPATCH8 | G patch domain containing 8 | 4.26958 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 4.26934 |
| INPP1 | inositol polyphosphate-1-phosphatase | 4.20287 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 4.19426 |
| SLC35F2 | solute carrier family 35, member F2 | 3.99888 |
| UBQLN2 | ubiquilin 2 | 3.94734 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.93411 |
| MAP7 | microtubule-associated protein 7 | 3.90952 |
| MVP | major vault protein | 3.90394 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.89017 |
| CHN1 | chimerin 1 | 3.8773 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 3.87708 |
| SFTPB | surfactant protein B | 3.85069 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.79254 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 3.71272 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 3.63603 |
| BZW2 | basic leucine zipper and W2 domains 2 | 3.54154 |
| TENT4A | terminal nucleotidyltransferase 4A | 3.43796 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 3.38608 |
| EPN2 | epsin 2 | 3.35288 |
| IER3 | immediate early response 3 | 3.33778 |
| ANGPTL4 | angiopoietin-like 4 | 3.10515 |
| TBPL1 | TBP-like 1 | 3.05635 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.03005 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.9073 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.88293 |
| ZMYM2 | zinc finger, MYM-type 2 | 2.86305 |
| S100A4 | S100 calcium binding protein A4 | 2.85363 |
| CBR3 | carbonyl reductase 3 | 2.84882 |
| EGR1 | early growth response 1 | 2.84795 |
| MAP7D1 | MAP7 domain containing 1 | 2.83221 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.79613 |
| SOX4 | SRY (sex determining region Y)-box 4 | 2.79419 |
| BAD | BCL2-associated agonist of cell death | 2.79073 |
| GOLT1B | golgi transport 1B | 2.75036 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.748 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 2.68886 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2.68516 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 2.66753 |
| KIFBP | kinesin family binding protein | 2.66159 |
| SLC75A1 | solute carrier family 75 member 1 | 2.65819 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.61591 |
| BTG3 | BTG family, member 3 | 2.59864 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 2.59314 |
| GRB10 | growth factor receptor-bound protein 10 | 2.5906 |
| ITGAV | integrin, alpha V | 2.54116 |
| SHB | Src homology 2 domain containing adaptor protein B | 2.53313 |
| PSME3 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 2.47438 |
| PIGT | phosphatidylinositol glycan anchor biosynthesis, class T | 2.47386 |
| TRIB1 | tribbles pseudokinase 1 | 2.46162 |
| EN1 | engrailed homeobox 1 | 2.46146 |
| VGLL4 | vestigial-like family member 4 | 2.45195 |
| MAGEA4 | melanoma antigen family A4 | 2.4361 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 2.42012 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.40873 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | 2.40721 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.40126 |
| GLRX | glutaredoxin (thioltransferase) | 2.37939 |
| KCNA1 | potassium channel, voltage gated shaker related subfamily A, member 1 | 2.37327 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.35925 |
| KDM5C | lysine (K)-specific demethylase 5C | 2.3581 |
| YIPF3 | Yip1 domain family, member 3 | 2.35071 |
| TXNRD1 | thioredoxin reductase 1 | 2.34188 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.34103 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.33852 |
| SLC35F6 | solute carrier family 35, member F6 | 2.33526 |
| EIF6 | eukaryotic translation initiation factor 6 | 2.33234 |
| ZPR1 | ZPR1 zinc finger | 2.32127 |
| TPM4 | tropomyosin 4 | 2.31925 |
| AGO2 | argonaute RISC catalytic component 2 | 2.30658 |
| TEX10 | testis expressed 10 | 2.29182 |
| CCNJL | cyclin J-like | 2.27172 |
| PTMS | parathymosin | 2.26222 |
| PSMD9 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 2.25948 |
| PPY | pancreatic polypeptide | 2.25056 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 2.23437 |
| ERCC1 | excision repair cross-complementation group 1 | 2.23097 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 2.22166 |
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 2.21832 |
| TP53BP2 | tumor protein p53 binding protein 2 | 2.20602 |
| CLTB | clathrin, light chain B | 2.20098 |
| ITGA10 | integrin, alpha 10 | 2.19672 |
| OSBPL3 | oxysterol binding protein-like 3 | 2.19389 |
| TREM2 | triggering receptor expressed on myeloid cells 2 | 2.18716 |
| TMEM39B | transmembrane protein 39B | 2.18182 |
| ZW10 | zw10 kinetochore protein | 2.18182 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.18097 |
| LRRTM2 | leucine rich repeat transmembrane neuronal 2 | 2.18012 |
| FRYL | FRY-like | 2.17571 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.16897 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 2.16782 |
| RAB5C | RAB5C, member RAS oncogene family | 2.16 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 2.15999 |
| LAP3 | leucine aminopeptidase 3 | 2.15885 |
| TMEM265 | transmembrane protein 265 | 2.15573 |
| CLEC5A | C-type lectin domain family 5, member A | 2.15409 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 2.15302 |
| PIH1D1 | PIH1 domain containing 1 | 2.15062 |
| FOXO3 | forkhead box O3 | 2.14138 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | 2.14113 |
| FKBP8 | FK506 binding protein 8, 38kDa | 2.13592 |
| CTSF | cathepsin F | 2.13497 |
| AQP3 | aquaporin 3 (Gill blood group) | 2.12667 |
| HSPA1B | heat shock 70kDa protein 1B | 2.12464 |
| MMP2 | matrix metallopeptidase 2 | 2.12361 |
| ZNF574 | zinc finger protein 574 | 2.12207 |
| PLAUR | plasminogen activator, urokinase receptor | 2.12108 |
| ADORA3 | adenosine A3 receptor | 2.12096 |
| CTSL | cathepsin L | 2.1161 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 2.1136 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 2.11263 |
| LGALSL | lectin, galactoside-binding-like | 2.11021 |
| GJB5 | gap junction protein, beta 5, 31.1kDa | 2.10996 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.09929 |
| LUZP1 | leucine zipper protein 1 | 2.09818 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 2.09239 |
| MTMR2 | myotubularin related protein 2 | 2.0904 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 2.08937 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | 2.08059 |
| SCAMP2 | secretory carrier membrane protein 2 | 2.07751 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 2.07607 |
| FOXD1 | forkhead box D1 | 2.0742 |
| ITPKC | inositol-trisphosphate 3-kinase C | 2.07327 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.06945 |
| SMAD3 | SMAD family member 3 | 2.06422 |
| ZFP36 | ZFP36 ring finger protein | 2.05643 |
| SERTAD2 | SERTA domain containing 2 | 2.05161 |
| SOCS5 | suppressor of cytokine signaling 5 | 2.04951 |
| MCOLN1 | mucolipin 1 | 2.04845 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | 2.04664 |
| APH1B | APH1B gamma secretase subunit | 2.03839 |
| AARSD1 | alanyl-tRNA synthetase domain containing 1 | 2.03837 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.03167 |
| HOXD1 | homeobox D1 | 2.02029 |
| DCC | DCC netrin 1 receptor | 2.01562 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 2.01227 |
| AHNAK2 | AHNAK nucleoprotein 2 | 2.0041 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.00362 |
| RAB43 | RAB43, member RAS oncogene family | 2.0014 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -10.0 |
| ISOC1 | isochorismatase domain containing 1 | -9.50761 |
| FGFR4 | fibroblast growth factor receptor 4 | -7.96134 |
| LDHD | lactate dehydrogenase D | -6.69156 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -6.44955 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -6.4251 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -6.36519 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.89367 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -5.78709 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -5.76804 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -5.52683 |
| USP6NL | USP6 N-terminal like | -5.29182 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -4.8187 |
| TCTN1 | tectonic family member 1 | -4.66077 |
| PGM1 | phosphoglucomutase 1 | -4.56084 |
| UGDH | UDP-glucose 6-dehydrogenase | -4.46279 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -4.40604 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -4.20271 |
| ANKRD10 | ankyrin repeat domain 10 | -4.18012 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.99295 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.95159 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.93238 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.88692 |
| GALE | UDP-galactose-4-epimerase | -3.81638 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -3.75885 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.73862 |
| HADH | hydroxyacyl-CoA dehydrogenase | -3.73512 |
| TMEM97 | transmembrane protein 97 | -3.69812 |
| SOAT2 | sterol O-acyltransferase 2 | -3.6133 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -3.59538 |
| TCERG1 | transcription elongation regulator 1 | -3.57226 |
| NISCH | nischarin | -3.53254 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.49734 |
| CDC20 | cell division cycle 20 | -3.49086 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.48191 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.47163 |
| C5 | complement component 5 | -3.35988 |
| PYGL | phosphorylase, glycogen, liver | -3.34465 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.22442 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.22411 |
| GDF15 | growth differentiation factor 15 | -3.18175 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.15643 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.0916 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -3.06954 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.04799 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -3.04262 |
| PLA1A | phospholipase A1 member A | -3.04136 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | -2.97975 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | -2.96653 |
| COG2 | component of oligomeric golgi complex 2 | -2.92127 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.88131 |
| KLHDC2 | kelch domain containing 2 | -2.80548 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -2.80244 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.80166 |
| PHGDH | phosphoglycerate dehydrogenase | -2.8 |
| PTCD1 | pentatricopeptide repeat domain 1 | -2.76139 |
| LBR | lamin B receptor | -2.74204 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -2.72723 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -2.68451 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.68063 |
| DSG2 | desmoglein 2 | -2.67477 |
| DCXR | dicarbonyl/L-xylulose reductase | -2.66182 |
| OXSM | 3-oxoacyl-ACP synthase, mitochondrial | -2.63017 |
| DENND2D | DENN/MADD domain containing 2D | -2.60581 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | -2.58229 |
| GAA | glucosidase, alpha; acid | -2.57026 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.5396 |
| ETNK2 | ethanolamine kinase 2 | -2.52902 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -2.50386 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.47361 |
| A1CF | APOBEC1 complementation factor | -2.46822 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.4627 |
| OXSR1 | oxidative stress responsive 1 | -2.46094 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.45741 |
| ERLIN2 | ER lipid raft associated 2 | -2.43458 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | -2.4285 |
| ARSL | arylsulfatase L | -2.42507 |
| APOM | apolipoprotein M | -2.42078 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | -2.39599 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -2.3506 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.33297 |
| CBR4 | carbonyl reductase 4 | -2.32439 |
| AMT | aminomethyltransferase | -2.31271 |
| AHSG | alpha-2-HS-glycoprotein | -2.3005 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | -2.29981 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -2.2929 |
| PROS1 | protein S (alpha) | -2.287 |
| SCARB1 | scavenger receptor class B, member 1 | -2.28664 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | -2.27292 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | -2.26769 |
| APOA2 | apolipoprotein A-II | -2.2675 |
| TRAP1 | TNF receptor-associated protein 1 | -2.26534 |
| UBE3C | ubiquitin protein ligase E3C | -2.26398 |
| MYLK | myosin light chain kinase | -2.25999 |
| DHRS4 | dehydrogenase/reductase (SDR family) member 4 | -2.25978 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -2.25432 |
| MSH6 | mutS homolog 6 | -2.2369 |
| HYOU1 | hypoxia up-regulated 1 | -2.22831 |
| RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | -2.22767 |
| CD200 | CD200 molecule | -2.21678 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.2108 |
| GYG2 | glycogenin 2 | -2.19693 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.1965 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | -2.19253 |
| DENND10 | DENN domain containing 10 | -2.19035 |
| PNPLA3 | patatin-like phospholipase domain containing 3 | -2.18747 |
| UGT2A3 | UDP glucuronosyltransferase 2 family, polypeptide A3 | -2.18531 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.18097 |
| PSPH | phosphoserine phosphatase | -2.1748 |
| SLC16A6 | solute carrier family 16, member 6 | -2.17358 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -2.16863 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -2.15666 |
| ZNF318 | zinc finger protein 318 | -2.14361 |
| CCNA2 | cyclin A2 | -2.1372 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.13687 |
| PTCD3 | pentatricopeptide repeat domain 3 | -2.13577 |
| COG7 | component of oligomeric golgi complex 7 | -2.12837 |
| NEK4 | NIMA-related kinase 4 | -2.12042 |
| PAAF1 | proteasomal ATPase-associated factor 1 | -2.11986 |
| ASGR1 | asialoglycoprotein receptor 1 | -2.11766 |
| FABP1 | fatty acid binding protein 1, liver | -2.10735 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.10585 |
| VTN | vitronectin | -2.10459 |
| TESK2 | testis-specific kinase 2 | -2.09906 |
| CA5A | carbonic anhydrase VA, mitochondrial | -2.08212 |
| GLDC | glycine dehydrogenase (decarboxylating) | -2.0718 |
| MTERF3 | mitochondrial transcription termination factor 3 | -2.06876 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | -2.06821 |
| MATN2 | matrilin 2 | -2.06779 |
| FADS2 | fatty acid desaturase 2 | -2.06737 |
| COX15 | cytochrome c oxidase assembly homolog 15 (yeast) | -2.05518 |
| TRIM37 | tripartite motif containing 37 | -2.05161 |
| RPIA | ribose 5-phosphate isomerase A | -2.03615 |
| PAH | phenylalanine hydroxylase | -2.03507 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.03248 |
| APOC3 | apolipoprotein C-III | -2.03182 |
| MLEC | malectin | -2.02852 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -2.01996 |
| ORM2 | orosomucoid 2 | -2.01765 |
| ANG | angiogenin, ribonuclease, RNase A family, 5 | -2.01685 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.00878 |
| TRAPPC8 | trafficking protein particle complex 8 | -2.00875 |
| AGMAT | agmatine ureohydrolase (agmatinase) | -2.007 |
| FOXA2 | forkhead box A2 | -2.00434 |
