CRCGN014_HEPG2_24H:P05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrochlorothiazide 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN014_HEPG2_24H:P05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.81166
CCL2 chemokine (C-C motif) ligand 2 5.54077
SATB1 SATB homeobox 1 4.26591
CARMIL1 capping protein regulator and myosin 1 linker 1 3.91461
CBR3 carbonyl reductase 3 3.74339
HLA-DRA major histocompatibility complex, class II, DR alpha 3.37717
CXCL2 chemokine (C-X-C motif) ligand 2 3.13717
BZW2 basic leucine zipper and W2 domains 2 3.03561
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.00776
ADRB2 adrenoceptor beta 2, surface 2.81561
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.76774
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.76142
CIAO3 cytosolic iron-sulfur assembly component 3 2.75682
ABHD6 abhydrolase domain containing 6 2.74448
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.65404
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.57336
DYNLT3 dynein, light chain, Tctex-type 3 2.55106
EPHB2 EPH receptor B2 2.41817
LYN LYN proto-oncogene, Src family tyrosine kinase 2.38708
TRAM2 translocation associated membrane protein 2 2.37709
RPP38 ribonuclease P/MRP 38kDa subunit 2.34468
PEX11A peroxisomal biogenesis factor 11 alpha 2.34253
SNAP25 synaptosomal-associated protein, 25kDa 2.32875
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.29913
ATP11B ATPase, class VI, type 11B 2.16519

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.00947
KDM3A lysine (K)-specific demethylase 3A -4.02116
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.84225
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.48997
SNX11 sorting nexin 11 -3.40165
NGRN neugrin, neurite outgrowth associated -3.2729
ZMIZ1 zinc finger, MIZ-type containing 1 -3.16866
LDHD lactate dehydrogenase D -3.05666
ZNF586 zinc finger protein 586 -2.90869
CCNB2 cyclin B2 -2.81668
CHMP4B charged multivesicular body protein 4B -2.78077
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.63136
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.50747
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.26569
CDC25B cell division cycle 25B -2.08679
IFT22 intraflagellar transport 22 -2.07072
YME1L1 YME1-like 1 ATPase -2.05802