CRCGN014_HEPG2_24H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(1-naphthyl)ethylenediamine.2hcl 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN014_HEPG2_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.44384
ALDOC aldolase C, fructose-bisphosphate 4.67983
ABHD4 abhydrolase domain containing 4 4.49727
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 4.31407
TCEA2 transcription elongation factor A (SII), 2 4.26524
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 4.26269
FDFT1 farnesyl-diphosphate farnesyltransferase 1 4.17058
NOTCH1 notch 1 4.03157
ELOVL6 ELOVL fatty acid elongase 6 3.95205
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.94189
TCTN1 tectonic family member 1 3.91662
STAP2 signal transducing adaptor family member 2 3.87176
CDC45 cell division cycle 45 3.70329
MYLK myosin light chain kinase 3.62807
ECH1 enoyl CoA hydratase 1, peroxisomal 3.62263
VAT1 vesicle amine transport 1 3.55475
ATP11B ATPase, class VI, type 11B 3.53874
WFS1 Wolfram syndrome 1 (wolframin) 3.50313
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.41229
ALAS1 5'-aminolevulinate synthase 1 3.39996
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.39514
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.37958
SOAT2 sterol O-acyltransferase 2 3.34154
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.31744
RAP1GAP RAP1 GTPase activating protein 3.27303
MTERF3 mitochondrial transcription termination factor 3 3.26196
LYN LYN proto-oncogene, Src family tyrosine kinase 3.17379
HMOX1 heme oxygenase 1 3.00217
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.89749
KLHL21 kelch-like family member 21 2.64645
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.55779
RALGDS ral guanine nucleotide dissociation stimulator 2.54764
STXBP1 syntaxin binding protein 1 2.51866
TMEM97 transmembrane protein 97 2.51728
HLA-DRA major histocompatibility complex, class II, DR alpha 2.46135
SFTPB surfactant protein B 2.42513
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.37302
MVP major vault protein 2.3011
TMEM109 transmembrane protein 109 2.28443
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.27804
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.27399
SATB1 SATB homeobox 1 2.27385
SCGB1D1 secretoglobin, family 1D, member 1 2.27111
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.26006
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.22419
CCDC92 coiled-coil domain containing 92 2.21788
TIAM1 T-cell lymphoma invasion and metastasis 1 2.19887
TPD52L2 tumor protein D52-like 2 2.18272
MXI1 MAX interactor 1, dimerization protein 2.17723
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.16645
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.14944
SQLE squalene epoxidase 2.13696
MINDY1 MINDY lysine 48 deubiquitinase 1 2.13388
LGALS1 lectin, galactoside-binding, soluble, 1 2.10668
NMU neuromedin U 2.08847
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.07844
NUPR1 nuclear protein, transcriptional regulator, 1 2.03168
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.01713

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -4.96362
UBE2C ubiquitin-conjugating enzyme E2C -4.48523
ZNF586 zinc finger protein 586 -4.21025
CDC20 cell division cycle 20 -3.98978
IER3 immediate early response 3 -3.93063
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.72422
FBXL12 F-box and leucine-rich repeat protein 12 -3.53244
ZNF274 zinc finger protein 274 -3.51951
PLK1 polo-like kinase 1 -3.50481
FASTKD5 FAST kinase domains 5 -3.47951
LDHD lactate dehydrogenase D -3.33124
CDK1 cyclin-dependent kinase 1 -3.31213
ADI1 acireductone dioxygenase 1 -3.24071
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.14582
PSRC1 proline/serine-rich coiled-coil 1 -3.13879
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.13266
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.06695
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.05876
FAT1 FAT atypical cadherin 1 -3.05363
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.01834
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.83858
TOP2A topoisomerase (DNA) II alpha 170kDa -2.78222
RPS5 ribosomal protein S5 -2.75426
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.74848
HAT1 histone acetyltransferase 1 -2.625
SLC35F2 solute carrier family 35, member F2 -2.51035
MAPK13 mitogen-activated protein kinase 13 -2.4805
YME1L1 YME1-like 1 ATPase -2.48028
MYCBP MYC binding protein -2.46579
CCNA2 cyclin A2 -2.3945
PCCB propionyl CoA carboxylase, beta polypeptide -2.34025
RNF167 ring finger protein 167 -2.31548
SMC4 structural maintenance of chromosomes 4 -2.30749
TLR4 toll-like receptor 4 -2.16887
CD320 CD320 molecule -2.13921
NDC80 NDC80 kinetochore complex component -2.1251
NUP85 nucleoporin 85kDa -2.11907
TCERG1 transcription elongation regulator 1 -2.11272
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.11161
TBPL1 TBP-like 1 -2.10094
PGAM4 phosphoglycerate mutase family member 4 -2.0914
ANKRD10 ankyrin repeat domain 10 -2.03874
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.03833
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.01614
MKI67 marker of proliferation Ki-67 -2.0015