CRCGN014_HEPG2_24H:P09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclopentanone oxime 41.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_24H:P09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.34632
AMDHD2 amidohydrolase domain containing 2 4.22995
CHN1 chimerin 1 4.08829
UBQLN2 ubiquilin 2 3.60926
HOXA10 homeobox A10 3.31373
CHMP6 charged multivesicular body protein 6 3.11974
ABHD6 abhydrolase domain containing 6 2.74651
CARMIL1 capping protein regulator and myosin 1 linker 1 2.65263
GPER1 G protein-coupled estrogen receptor 1 2.652
BIRC2 baculoviral IAP repeat containing 2 2.55337
ADGRE5 adhesion G protein-coupled receptor E5 2.50877
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.44587
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.43603
CYCS cytochrome c, somatic 2.42246
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.4166
JADE2 jade family PHD finger 2 2.30972
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.28874
LOC122526780 uncharacterized LOC122526780 2.16556
GPATCH8 G patch domain containing 8 2.13791
SNX7 sorting nexin 7 2.09133
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.06202

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -4.1229
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.88643
VAT1 vesicle amine transport 1 -3.77984
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.46002
NUP85 nucleoporin 85kDa -3.27897
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.08967
NGRN neugrin, neurite outgrowth associated -2.85024
HSPB1 heat shock 27kDa protein 1 -2.81452
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.63646
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.5727
HLA-DMA major histocompatibility complex, class II, DM alpha -2.44254
VDAC1 voltage-dependent anion channel 1 -2.37511
KCTD2 potassium channel tetramerization domain containing 2 -2.27312
CCNB2 cyclin B2 -2.22017
OXA1L oxidase (cytochrome c) assembly 1-like -2.1176
MRPL58 mitochondrial ribosomal protein L58 -2.01524
TRAPPC6A trafficking protein particle complex 6A -2.00933