CRCGN014_HEPG2_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description erythrosine 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN014_HEPG2_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 9.72056
BACE2 beta-site APP-cleaving enzyme 2 5.55494
LOC122526780 uncharacterized LOC122526780 5.18824
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.98523
CHN1 chimerin 1 4.85626
CCL2 chemokine (C-C motif) ligand 2 4.58584
E2F2 E2F transcription factor 2 4.46122
UBQLN2 ubiquilin 2 4.19825
MAP7 microtubule-associated protein 7 3.9068
SNAP25 synaptosomal-associated protein, 25kDa 3.8551
HEBP1 heme binding protein 1 3.72861
NOSIP nitric oxide synthase interacting protein 3.6915
MCM3 minichromosome maintenance complex component 3 3.11734
VGLL4 vestigial-like family member 4 2.9531
CXCL2 chemokine (C-X-C motif) ligand 2 2.80979
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.63784
GPATCH8 G patch domain containing 8 2.61407
CSK c-src tyrosine kinase 2.48056
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.39392
KIF20A kinesin family member 20A 2.34758
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.30362
PLPP2 phospholipid phosphatase 2 2.3007
HLA-DRA major histocompatibility complex, class II, DR alpha 2.25613
SUMO4 small ubiquitin-like modifier 4 2.21045
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.09617
RPA3 replication protein A3, 14kDa 2.01816

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.69386
NT5DC2 5'-nucleotidase domain containing 2 -5.47487
FBXL12 F-box and leucine-rich repeat protein 12 -4.8538
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.69119
ZMIZ1 zinc finger, MIZ-type containing 1 -4.57331
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.51893
C2CD5 C2 calcium-dependent domain containing 5 -4.50904
RAI14 retinoic acid induced 14 -3.35146
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.31251
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.15166
CD58 CD58 molecule -3.02032
CCNB2 cyclin B2 -3.00886
OXA1L oxidase (cytochrome c) assembly 1-like -2.98611
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.8214
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.67616
GRB7 growth factor receptor-bound protein 7 -2.65989
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.63338
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.59121
CRELD2 cysteine-rich with EGF-like domains 2 -2.51048
COG7 component of oligomeric golgi complex 7 -2.4726
DENND2D DENN/MADD domain containing 2D -2.43833
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.33404
ATXN7L1 ataxin 7-like 1 -2.26963
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.24108
TCAP titin-cap -2.19279
OSTF1 osteoclast stimulating factor 1 -2.17369
ZNF274 zinc finger protein 274 -2.13534
GPR25 G protein-coupled receptor 25 -2.1027
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.09181
CCNH cyclin H -2.06593
GPHRA golgi pH regulator A -2.05954
EDN1 endothelin 1 -2.05686
PGAP3 post-GPI attachment to proteins 3 -2.05386
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.03733
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 -2.02276