CRCGN014_HEPG2_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN014_HEPG2_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.06218
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.64498
GPER1 G protein-coupled estrogen receptor 1 4.62094
MOK MOK protein kinase 4.0839
EVL Enah/Vasp-like 3.6756
PLS1 plastin 1 3.43514
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.387
MYLK myosin light chain kinase 3.00886
LOC122526780 uncharacterized LOC122526780 2.99401
HLA-DRA major histocompatibility complex, class II, DR alpha 2.9923
SQOR sulfide quinone oxidoreductase 2.80479
GSTZ1 glutathione S-transferase zeta 1 2.59186
GATA3 GATA binding protein 3 2.53762
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.51438
LCN2 lipocalin 2 2.48598
NOSIP nitric oxide synthase interacting protein 2.45761
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.42786
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.32141
RAB21 RAB21, member RAS oncogene family 2.1898
UGDH UDP-glucose 6-dehydrogenase 2.18524
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.13331
CEMIP2 cell migration inducing hyaluronidase 2 2.08953
NUP133 nucleoporin 133kDa 2.02105

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.69197
NISCH nischarin -4.26454
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.69642
GDF15 growth differentiation factor 15 -3.28772
PCNA proliferating cell nuclear antigen -3.26314
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.93945
TM9SF3 transmembrane 9 superfamily member 3 -2.82749
MAPK13 mitogen-activated protein kinase 13 -2.70782
ZNF586 zinc finger protein 586 -2.23918
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.06115
PRKCQ protein kinase C, theta -2.03349