CRCGN014_HEPG2_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

102 genes differentially expressed following the CRCGN014_HEPG2_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.51159
PPARG peroxisome proliferator-activated receptor gamma 5.38029
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.10068
E2F2 E2F transcription factor 2 5.07654
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8997
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.76414
EAPP E2F-associated phosphoprotein 4.60558
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.59656
NOTCH1 notch 1 4.50195
SFTPB surfactant protein B 4.28263
STK10 serine/threonine kinase 10 4.21309
TIAM1 T-cell lymphoma invasion and metastasis 1 3.46103
CXCL2 chemokine (C-X-C motif) ligand 2 3.32923
SLC75A1 solute carrier family 75 member 1 3.07454
ZNF589 zinc finger protein 589 2.91953
UIMC1 ubiquitin interaction motif containing 1 2.83134
TMPRSS5 transmembrane protease, serine 5 2.8268
JADE2 jade family PHD finger 2 2.8016
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 2.67631
POU4F1 POU class 4 homeobox 1 2.62534
ADAMTSL4 ADAMTS-like 4 2.62243
ZIM2 zinc finger, imprinted 2 2.60304
MTA2 metastasis associated 1 family, member 2 2.55385
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.52485
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.52152
GCGR glucagon receptor 2.38797
PTK2 protein tyrosine kinase 2 2.34923
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.30305
RHOT2 ras homolog family member T2 2.25307
NPC1L1 NPC1-like 1 2.23961
KIF25 kinesin family member 25 2.23634
SMYD5 SMYD family member 5 2.20602
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.19756
MIA melanoma inhibitory activity 2.19516
CRYBA4 crystallin, beta A4 2.17622
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.17279
CNIH1 cornichon family AMPA receptor auxiliary protein 1 2.17223
ADTRP androgen-dependent TFPI-regulating protein 2.16594
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.15502
NLGN4Y neuroligin 4, Y-linked 2.14861
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.13873
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.13665
SIGLEC5 sialic acid binding Ig-like lectin 5 2.12991
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.12219
ZMYM3 zinc finger, MYM-type 3 2.10423
ZC3H3 zinc finger CCCH-type containing 3 2.10353
USP9X ubiquitin specific peptidase 9, X-linked 2.09125
S1PR4 sphingosine-1-phosphate receptor 4 2.08437
DMBT1 deleted in malignant brain tumors 1 2.07576
PGP phosphoglycolate phosphatase 2.06214
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.04368
LSAMP limbic system-associated membrane protein 2.04186
THRAP3 thyroid hormone receptor associated protein 3 2.04095
BIRC2 baculoviral IAP repeat containing 2 2.03832
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.02886
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.0282
MCRS1 microspherule protein 1 2.0238
ATG13 autophagy related 13 2.02064
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.01712
BFSP2 beaded filament structural protein 2, phakinin 2.01413
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.0062
CLINT1 clathrin interactor 1 2.00503
KIRREL1 kirre like nephrin family adhesion molecule 1 2.00456

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.57434
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.09476
MRPS2 mitochondrial ribosomal protein S2 -4.76194
LDHD lactate dehydrogenase D -4.64763
NRIP1 nuclear receptor interacting protein 1 -3.82427
CD320 CD320 molecule -3.76753
ITGB1BP1 integrin beta 1 binding protein 1 -3.6467
EGF epidermal growth factor -3.47858
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.39991
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.37046
RAI14 retinoic acid induced 14 -3.00733
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.77132
TLR4 toll-like receptor 4 -2.58346
FBXL12 F-box and leucine-rich repeat protein 12 -2.52244
KLHL26 kelch-like family member 26 -2.38684
DCTN6 dynactin 6 -2.36255
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.35524
HSPA2 heat shock 70kDa protein 2 -2.3109
DAAM2 dishevelled associated activator of morphogenesis 2 -2.30937
CTSD cathepsin D -2.26831
TXNDC9 thioredoxin domain containing 9 -2.24499
COG7 component of oligomeric golgi complex 7 -2.23026
FOSL2 FOS-like antigen 2 -2.19634
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.18695
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.16976
ZNF274 zinc finger protein 274 -2.16257
GPR183 G protein-coupled receptor 183 -2.16098
R3HCC1 R3H domain and coiled-coil containing 1 -2.14146
TLCD3A TLC domain containing 3A -2.12212
DRC11 dynein regulatory complex subunit 11 -2.10448
TTC38 tetratricopeptide repeat domain 38 -2.07055
IER5 immediate early response 5 -2.06765
PLK2 polo-like kinase 2 -2.05753
RBPMS RNA binding protein with multiple splicing -2.05731
HIKESHI heat shock protein nuclear import factor hikeshi -2.05321
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.04334
TMEM267 transmembrane protein 267 -2.02553
PAEP progestagen-associated endometrial protein -2.00269