CRCGN014_HEPG2_24H:P21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorphenamine 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

42 genes differentially expressed following the CRCGN014_HEPG2_24H:P21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.37304
NOSIP nitric oxide synthase interacting protein 4.78844
MYLK myosin light chain kinase 4.6786
CBR3 carbonyl reductase 3 4.6315
CHMP6 charged multivesicular body protein 6 4.5086
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 4.18551
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.15366
LOC122526780 uncharacterized LOC122526780 3.49337
HDGFL3 HDGF like 3 3.38144
TIAM1 T-cell lymphoma invasion and metastasis 1 3.36363
CEMIP2 cell migration inducing hyaluronidase 2 3.26664
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.09703
CDPF1 cysteine-rich, DPF motif domain containing 1 3.06648
SFTPB surfactant protein B 2.84567
GSTZ1 glutathione S-transferase zeta 1 2.76007
GPER1 G protein-coupled estrogen receptor 1 2.64223
ABHD4 abhydrolase domain containing 4 2.53428
ATP5F1A ATP synthase F1 subunit alpha 2.36155
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.18631
TMEM243 transmembrane protein 243, mitochondrial 2.02168

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -8.93479
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.2744
TUBB6 tubulin, beta 6 class V -4.92748
CCNB1 cyclin B1 -4.77908
FBXL12 F-box and leucine-rich repeat protein 12 -4.25143
CDC20 cell division cycle 20 -4.23634
RAI14 retinoic acid induced 14 -3.36185
HYOU1 hypoxia up-regulated 1 -3.31684
ELOVL1 ELOVL fatty acid elongase 1 -2.55482
GJB5 gap junction protein, beta 5, 31.1kDa -2.49998
FOXB1 forkhead box B1 -2.47499
EDN1 endothelin 1 -2.41736
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.30963
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.22102
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 -2.18446
HTRA1 HtrA serine peptidase 1 -2.15457
COG7 component of oligomeric golgi complex 7 -2.1482
NUP155 nucleoporin 155kDa -2.13001
STEEP1 STING1 ER exit protein 1 -2.0785
KIF26B kinesin family member 26B -2.06462
RNF167 ring finger protein 167 -2.05156
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.03135