CRCGN014_HEPG2_24H:P24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

697 genes differentially expressed following the CRCGN014_HEPG2_24H:P24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 10.0
MCOLN1 mucolipin 1 10.0
ABHD4 abhydrolase domain containing 4 9.8529
HMOX1 heme oxygenase 1 8.76132
H2BC12 H2B clustered histone 12 7.59288
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 7.5398
TIMP2 TIMP metallopeptidase inhibitor 2 7.23694
FOSL1 FOS-like antigen 1 7.2127
TXNRD1 thioredoxin reductase 1 7.02625
BIRC2 baculoviral IAP repeat containing 2 6.84108
HSPA1A heat shock 70kDa protein 1A 6.72819
FOXO4 forkhead box O4 6.35242
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 6.33175
KDM3A lysine (K)-specific demethylase 3A 6.25247
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 6.24556
TXNL4B thioredoxin-like 4B 5.90438
EAPP E2F-associated phosphoprotein 5.64488
FHL2 four and a half LIM domains 2 5.57993
NPC1 Niemann-Pick disease, type C1 5.56505
CBR1 carbonyl reductase 1 5.49866
ADI1 acireductone dioxygenase 1 5.34195
BLCAP bladder cancer associated protein 5.32019
RNMT RNA (guanine-7-) methyltransferase 5.31324
RRAGA Ras-related GTP binding A 5.2556
RNASE7 ribonuclease, RNase A family, 7 5.09128
DNM1L dynamin 1-like 5.07095
CAB39 calcium binding protein 39 5.01596
USP6NL USP6 N-terminal like 5.00796
FRS2 fibroblast growth factor receptor substrate 2 4.96011
CARMIL1 capping protein regulator and myosin 1 linker 1 4.8498
FASTKD5 FAST kinase domains 5 4.78843
SQSTM1 sequestosome 1 4.74614
LCN2 lipocalin 2 4.73787
GOLT1B golgi transport 1B 4.47471
DUSP14 dual specificity phosphatase 14 4.37212
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.37195
KEAP1 kelch-like ECH-associated protein 1 4.31515
CEMIP2 cell migration inducing hyaluronidase 2 4.28857
UBQLN2 ubiquilin 2 4.28347
BAG3 BCL2-associated athanogene 3 4.27356
ALAS1 5'-aminolevulinate synthase 1 4.21525
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 4.09712
TERF2IP telomeric repeat binding factor 2, interacting protein 4.08409
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 4.06617
PRKCD protein kinase C, delta 4.02042
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 4.01189
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.95158
CDPF1 cysteine-rich, DPF motif domain containing 1 3.93301
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 3.80115
TSC22D3 TSC22 domain family, member 3 3.79017
CIAO3 cytosolic iron-sulfur assembly component 3 3.77939
RRAGC Ras-related GTP binding C 3.76924
CNPY3 canopy FGF signaling regulator 3 3.76913
H2BC21 H2B clustered histone 21 3.75948
NOTCH1 notch 1 3.74151
RIOK3 RIO kinase 3 3.71716
KCTD5 potassium channel tetramerization domain containing 5 3.70574
TEX10 testis expressed 10 3.65971
HSPA1B heat shock 70kDa protein 1B 3.65617
CDK7 cyclin-dependent kinase 7 3.60097
GPATCH3 G patch domain containing 3 3.56367
WDR47 WD repeat domain 47 3.46757
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.45296
TRAK2 trafficking protein, kinesin binding 2 3.43982
IGF1R insulin-like growth factor 1 receptor 3.42697
IST1 increased sodium tolerance 1 homolog (yeast) 3.42504
CCL2 chemokine (C-C motif) ligand 2 3.42061
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 3.41831
YPEL5 yippee-like 5 (Drosophila) 3.39825
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.38398
GTF2B general transcription factor IIB 3.32553
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 3.30797
GADD45B growth arrest and DNA-damage-inducible, beta 3.30596
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 3.24131
UBE2A ubiquitin-conjugating enzyme E2A 3.23984
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3.23218
OSGIN1 oxidative stress induced growth inhibitor 1 3.19677
RALB v-ral simian leukemia viral oncogene homolog B 3.19223
BTG1 B-cell translocation gene 1, anti-proliferative 3.18072
IGHMBP2 immunoglobulin mu binding protein 2 3.17079
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.14522
SDF2 stromal cell-derived factor 2 3.13106
NCOA3 nuclear receptor coactivator 3 3.12015
CXCL2 chemokine (C-X-C motif) ligand 2 3.09434
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 3.06502
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 3.05726
GNPDA1 glucosamine-6-phosphate deaminase 1 3.05436
ATG101 autophagy related 101 3.04007
SMG8 SMG8 nonsense mediated mRNA decay factor 3.03572
ABI1 abl-interactor 1 3.03264
ZNF646 zinc finger protein 646 3.01635
STX3 syntaxin 3 2.99792
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.98635
ROM1 retinal outer segment membrane protein 1 2.98589
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.97717
ARL4C ADP-ribosylation factor-like 4C 2.97556
MTCH1 mitochondrial carrier 1 2.96151
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 2.9565
ARL8B ADP-ribosylation factor-like 8B 2.94272
PLEKHO2 pleckstrin homology domain containing, family O member 2 2.91321
TBPL1 TBP-like 1 2.90862
ECD ecdysoneless homolog (Drosophila) 2.90237
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.89876
MICALL1 MICAL-like 1 2.89557
RNF114 ring finger protein 114 2.88944
FBXO7 F-box protein 7 2.88344
CCND3 cyclin D3 2.87823
ANKRD12 ankyrin repeat domain 12 2.8758
TBC1D15 TBC1 domain family, member 15 2.86707
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.8598
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.85813
TP53BP2 tumor protein p53 binding protein 2 2.85252
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.85089
CYTH1 cytohesin 1 2.84148
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.84098
TCF15 transcription factor 15 (basic helix-loop-helix) 2.82239
PGRMC1 progesterone receptor membrane component 1 2.81986
OSER1 oxidative stress responsive serine-rich 1 2.81686
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.81569
TBCC tubulin folding cofactor C 2.80799
GRN granulin 2.80011
EMC3 ER membrane protein complex subunit 3 2.79371
RMC1 regulator of MON1-CCZ1 2.78255
DOHH deoxyhypusine hydroxylase/monooxygenase 2.77489
MAP7D1 MAP7 domain containing 1 2.77067
MALT1 MALT1 paracaspase 2.76571
SYNE2 spectrin repeat containing, nuclear envelope 2 2.72743
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.72724
RTF2 replication termination factor 2 2.72123
YAP1 Yes-associated protein 1 2.69406
RNF113A ring finger protein 113A 2.6787
CREG1 cellular repressor of E1A-stimulated genes 1 2.67378
TMEM127 transmembrane protein 127 2.66397
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.65653
TM9SF2 transmembrane 9 superfamily member 2 2.64993
GCLM glutamate-cysteine ligase, modifier subunit 2.64459
TMEM50A transmembrane protein 50A 2.64239
H2AC6 H2A clustered histone 6 2.63053
C6ORF89 chromosome 6 open reading frame 89 2.6297
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 2.62578
LGMN legumain 2.62558
LHFPL2 lipoma HMGIC fusion partner-like 2 2.61661
TSC22D4 TSC22 domain family, member 4 2.58388
RAB5IF RAB5 interacting factor 2.58235
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.57938
HCCS holocytochrome c synthase 2.56537
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.56018
USP3 ubiquitin specific peptidase 3 2.55875
NRBP1 nuclear receptor binding protein 1 2.55746
FICD FIC domain containing 2.54259
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.54192
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.53728
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.53307
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.52885
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.52724
ZNF212 zinc finger protein 212 2.5112
BRD2 bromodomain containing 2 2.50939
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.50594
TRAFD1 TRAF-type zinc finger domain containing 1 2.50129
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.48855
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.4878
ANO10 anoctamin 10 2.48394
MVP major vault protein 2.48173
ASDURF ASNSD1 upstream open reading frame 2.48033
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.47789
MAD2L1BP MAD2L1 binding protein 2.47589
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.46492
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.46216
TUFT1 tuftelin 1 2.45894
BBC3 BCL2 binding component 3 2.45801
MICB MHC class I polypeptide-related sequence B 2.44812
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.44796
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.44728
ADM adrenomedullin 2.4467
CTSL cathepsin L 2.43029
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.42814
PRDM4 PR domain containing 4 2.42189
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.41739
BEST1 bestrophin 1 2.41738
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.40857
ELF4 E74-like factor 4 (ets domain transcription factor) 2.40643
FURIN furin (paired basic amino acid cleaving enzyme) 2.4017
HINFP histone H4 transcription factor 2.39977
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.3959
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.39319
SOWAHC sosondowah ankyrin repeat domain family member C 2.39279
TRIM38 tripartite motif containing 38 2.39234
GRB2 growth factor receptor-bound protein 2 2.38978
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.38684
STIP1 stress-induced phosphoprotein 1 2.38564
CCP110 centriolar coiled coil protein 110kDa 2.37881
CDK11A cyclin-dependent kinase 11A 2.37797
SNAP23 synaptosomal-associated protein, 23kDa 2.37234
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.36887
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.36555
HSPH1 heat shock 105kDa/110kDa protein 1 2.36211
RTN4 reticulon 4 2.36174
ZNF292 zinc finger protein 292 2.36099
RAB9A RAB9A, member RAS oncogene family 2.35701
RESF1 retroelement silencing factor 1 2.35681
MYT1 myelin transcription factor 1 2.35252
RND3 Rho family GTPase 3 2.35245
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.3487
ZBTB43 zinc finger and BTB domain containing 43 2.34694
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.34512
CABP2 calcium binding protein 2 2.34356
DIPK1A divergent protein kinase domain 1A 2.33776
SNIP1 Smad nuclear interacting protein 1 2.33029
GDI2 GDP dissociation inhibitor 2 2.32767
GADD45A growth arrest and DNA-damage-inducible, alpha 2.32339
TATDN2 TatD DNase domain containing 2 2.32204
MOSPD1 motile sperm domain containing 1 2.3209
FOXO3 forkhead box O3 2.31992
AIM2 absent in melanoma 2 2.31467
RAB21 RAB21, member RAS oncogene family 2.31322
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.3106
SPI1 Spi-1 proto-oncogene 2.30238
BBX bobby sox homolog (Drosophila) 2.29471
SIRT7 sirtuin 7 2.29368
SERTAD2 SERTA domain containing 2 2.2929
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.29241
CORO1C coronin, actin binding protein, 1C 2.28951
SECISBP2L SECIS binding protein 2-like 2.28379
TMEM109 transmembrane protein 109 2.27084
NPC2 Niemann-Pick disease, type C2 2.2701
NFE2L1 nuclear factor, erythroid 2-like 1 2.26729
KRT14 keratin 14, type I 2.25532
UBXN7 UBX domain protein 7 2.25274
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.25008
UNC93B1 unc-93 homolog B1 (C. elegans) 2.24957
OBP2B odorant binding protein 2B 2.24825
MED17 mediator complex subunit 17 2.24823
MXI1 MAX interactor 1, dimerization protein 2.24696
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.24641
DAPK3 death-associated protein kinase 3 2.24496
WASF3 WAS protein family, member 3 2.24214
ZNF394 zinc finger protein 394 2.24202
LAP3 leucine aminopeptidase 3 2.24116
CLTC clathrin, heavy chain (Hc) 2.23442
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.23389
LRP12 low density lipoprotein receptor-related protein 12 2.23328
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 2.22462
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.22204
KDM2A lysine (K)-specific demethylase 2A 2.22165
CGRRF1 cell growth regulator with ring finger domain 1 2.21975
SAA2 serum amyloid A2 2.21873
MYOG myogenin (myogenic factor 4) 2.21707
H2BC9 H2B clustered histone 9 2.21603
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.21585
FAM13B family with sequence similarity 13, member B 2.21527
FEM1C fem-1 homolog c (C. elegans) 2.21066
H2BC4 H2B clustered histone 4 2.20798
RUNX1 runt-related transcription factor 1 2.20472
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.20404
IL11 interleukin 11 2.20215
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.2014
SMAD3 SMAD family member 3 2.19767
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.19599
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.19364
UBN1 ubinuclein 1 2.18694
ARHGAP12 Rho GTPase activating protein 12 2.18266
CLN3 ceroid-lipofuscinosis, neuronal 3 2.1793
EVI2B ecotropic viral integration site 2B 2.17865
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.17857
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.17804
DCAF6 DDB1 and CUL4 associated factor 6 2.17713
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 2.1757
LSM1 LSM1, U6 small nuclear RNA associated 2.1752
CTNS cystinosin, lysosomal cystine transporter 2.17516
HOXA5 homeobox A5 2.17423
SMIM29 small integral membrane protein 29 2.17386
BPGM 2,3-bisphosphoglycerate mutase 2.16446
SLC61A1 solute carrier family 61 member 1 2.16426
ISCA1 iron-sulfur cluster assembly 1 2.15934
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.1541
HPS5 Hermansky-Pudlak syndrome 5 2.14897
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 2.14721
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.14536
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.14405
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.14215
YY1AP1 YY1 associated protein 1 2.13984
HEXIM1 hexamethylene bis-acetamide inducible 1 2.13877
SEPHS2 selenophosphate synthetase 2 2.13823
HSPB1 heat shock 27kDa protein 1 2.13797
MPZL1 myelin protein zero-like 1 2.13344
SLC25A44 solute carrier family 25, member 44 2.12992
PEA15 phosphoprotein enriched in astrocytes 15 2.12969
OGFR opioid growth factor receptor 2.12933
AMN amnion associated transmembrane protein 2.1262
AARS1 alanyl-tRNA synthetase 1 2.1239
GPC1 glypican 1 2.12363
TUT7 terminal uridylyl transferase 7 2.12304
DAZAP2 DAZ associated protein 2 2.11984
ZBTB11 zinc finger and BTB domain containing 11 2.11978
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.11539
TBK1 TANK-binding kinase 1 2.11347
KDM5A lysine (K)-specific demethylase 5A 2.11297
SYNRG synergin, gamma 2.11282
PELO pelota homolog (Drosophila) 2.10106
LOC128125814 uncharacterized LOC128125814 2.10092
PMCH pro-melanin-concentrating hormone 2.09985
WAC WW domain containing adaptor with coiled-coil 2.09931
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.09463
DSE dermatan sulfate epimerase 2.09233
TRAPPC3 trafficking protein particle complex 3 2.09124
EIF4A3 eukaryotic translation initiation factor 4A3 2.08524
TXNL1 thioredoxin-like 1 2.08451
VAMP3 vesicle-associated membrane protein 3 2.08105
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.08038
CSF1R colony stimulating factor 1 receptor 2.07814
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.07286
REEP5 receptor accessory protein 5 2.07275
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.07137
NUP58 nucleoporin 58 2.06852
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.06516
TRIP12 thyroid hormone receptor interactor 12 2.06355
STK38 serine/threonine kinase 38 2.06002
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.05694
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.05449
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.05359
CCNL1 cyclin L1 2.0534
RB1CC1 RB1-inducible coiled-coil 1 2.05336
ZDHHC7 zinc finger, DHHC-type containing 7 2.04582
BARX1 BARX homeobox 1 2.0455
KLHL25 kelch-like family member 25 2.03968
THUMPD1 THUMP domain containing 1 2.03776
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.03486
ABHD5 abhydrolase domain containing 5 2.0341
BLTP3B bridge-like lipid transfer protein family member 3B 2.03335
MBD4 methyl-CpG binding domain protein 4 2.03235
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 2.02967
PELI1 pellino E3 ubiquitin protein ligase 1 2.02846
RPP38 ribonuclease P/MRP 38kDa subunit 2.02772
GGNBP2 gametogenetin binding protein 2 2.02732
BPTF bromodomain PHD finger transcription factor 2.02498
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.02355
ZNF227 zinc finger protein 227 2.0228
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.02263
SAMD9 sterile alpha motif domain containing 9 2.02206
SUCO SUN domain containing ossification factor 2.02206
FGD6 FYVE, RhoGEF and PH domain containing 6 2.02193
LASP1 LIM and SH3 protein 1 2.02094
CREBBP CREB binding protein 2.02047
R3HCC1L R3H domain and coiled-coil containing 1-like 2.01708
FZD7 frizzled class receptor 7 2.01678
MKRN1 makorin ring finger protein 1 2.01572
RSRC2 arginine/serine-rich coiled-coil 2 2.01022
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.00911
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.00843
RBBP5 retinoblastoma binding protein 5 2.00705
GP9 glycoprotein IX (platelet) 2.0048
RABEP2 rabaptin, RAB GTPase binding effector protein 2 2.00447
KANSL2 KAT8 regulatory NSL complex subunit 2 2.00304
RNF25 ring finger protein 25 2.00145

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -10.0
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -9.05242
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -8.47107
B4GAT1 beta-1,4-glucuronyltransferase 1 -7.90606
INTS3 integrator complex subunit 3 -7.76519
C2CD5 C2 calcium-dependent domain containing 5 -7.24542
COG2 component of oligomeric golgi complex 2 -6.78568
ETFB electron-transfer-flavoprotein, beta polypeptide -6.61736
CD320 CD320 molecule -6.42307
SLC35F2 solute carrier family 35, member F2 -6.07871
TRAP1 TNF receptor-associated protein 1 -5.95545
UBE3C ubiquitin protein ligase E3C -5.86993
PLS1 plastin 1 -5.80786
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -5.7311
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -5.64218
CDC20 cell division cycle 20 -5.51396
COG7 component of oligomeric golgi complex 7 -5.38354
MELK maternal embryonic leucine zipper kinase -5.24234
PECR peroxisomal trans-2-enoyl-CoA reductase -5.20802
RPIA ribose 5-phosphate isomerase A -5.16664
GLOD4 glyoxalase domain containing 4 -5.08822
HMGA2 high mobility group AT-hook 2 -5.05123
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.04949
MRPS16 mitochondrial ribosomal protein S16 -4.96268
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.89387
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -4.81847
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -4.8139
TOP2A topoisomerase (DNA) II alpha 170kDa -4.80559
GNAS GNAS complex locus -4.77726
LBR lamin B receptor -4.74155
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.7387
STAP2 signal transducing adaptor family member 2 -4.73152
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.7102
TSPAN4 tetraspanin 4 -4.68168
PYCR1 pyrroline-5-carboxylate reductase 1 -4.66826
ENOPH1 enolase-phosphatase 1 -4.65877
NISCH nischarin -4.6403
STK25 serine/threonine kinase 25 -4.62645
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -4.58944
FGFR4 fibroblast growth factor receptor 4 -4.55634
DPH2 DPH2 homolog (S. cerevisiae) -4.55545
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.49355
ACAA1 acetyl-CoA acyltransferase 1 -4.46736
NNT nicotinamide nucleotide transhydrogenase -4.45371
GALE UDP-galactose-4-epimerase -4.42957
LDHD lactate dehydrogenase D -4.40735
CCNA2 cyclin A2 -4.36905
NIPSNAP1 nipsnap homolog 1 (C. elegans) -4.35958
CDK4 cyclin-dependent kinase 4 -4.31314
HADH hydroxyacyl-CoA dehydrogenase -4.22111
DDB2 damage-specific DNA binding protein 2, 48kDa -4.21406
PGM1 phosphoglucomutase 1 -4.2079
NENF neudesin neurotrophic factor -4.20493
MRPL19 mitochondrial ribosomal protein L19 -4.08454
MYLK myosin light chain kinase -4.08214
HEATR1 HEAT repeat containing 1 -4.034
PSRC1 proline/serine-rich coiled-coil 1 -3.97041
CRELD2 cysteine-rich with EGF-like domains 2 -3.92783
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.91581
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.89921
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.84755
DSG2 desmoglein 2 -3.8256
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -3.81468
ASCC3 activating signal cointegrator 1 complex subunit 3 -3.79518
RUVBL1 RuvB-like AAA ATPase 1 -3.74784
ACOD1 aconitate decarboxylase 1 -3.72263
C5 complement component 5 -3.68285
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.64446
MRPL12 mitochondrial ribosomal protein L12 -3.61121
PDHB pyruvate dehydrogenase (lipoamide) beta -3.59204
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.58152
CDK1 cyclin-dependent kinase 1 -3.54831
NHP2 NHP2 ribonucleoprotein -3.53136
TRIP13 thyroid hormone receptor interactor 13 -3.52735
KIF4A kinesin family member 4A -3.49656
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.44982
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.44775
FOXM1 forkhead box M1 -3.40576
CHMP6 charged multivesicular body protein 6 -3.38617
NT5DC2 5'-nucleotidase domain containing 2 -3.35866
COG4 component of oligomeric golgi complex 4 -3.34741
TCTN3 tectonic family member 3 -3.34675
ZMYM3 zinc finger, MYM-type 3 -3.3332
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -3.30135
AURKB aurora kinase B -3.238
MCM3 minichromosome maintenance complex component 3 -3.23442
NUP85 nucleoporin 85kDa -3.21955
TCERG1 transcription elongation regulator 1 -3.20319
HYOU1 hypoxia up-regulated 1 -3.16308
ZDHHC6 zinc finger, DHHC-type containing 6 -3.15444
NEK4 NIMA-related kinase 4 -3.15426
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -3.14922
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.14823
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -3.13373
PYGL phosphorylase, glycogen, liver -3.12736
RSU1 Ras suppressor protein 1 -3.12733
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -3.11365
PXMP2 peroxisomal membrane protein 2, 22kDa -3.11081
MSH5 mutS homolog 5 -3.08092
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.04741
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -3.04532
DNAAF5 dynein, axonemal, assembly factor 5 -3.02929
CHMP4B charged multivesicular body protein 4B -2.95241
MTA1 metastasis associated 1 -2.95222
AKAP8 A kinase (PRKA) anchor protein 8 -2.94492
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.9274
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.91246
STX8 syntaxin 8 -2.9069
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.88736
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.8771
ACY1 aminoacylase 1 -2.87701
KIF15 kinesin family member 15 -2.87148
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.86902
UBE2C ubiquitin-conjugating enzyme E2C -2.86857
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.86302
PRR3 proline rich 3 -2.85723
NIT1 nitrilase 1 -2.85289
APEH acylaminoacyl-peptide hydrolase -2.81998
CUEDC2 CUE domain containing 2 -2.80886
NCAPG2 non-SMC condensin II complex, subunit G2 -2.78912
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.77719
ASF1B anti-silencing function 1B histone chaperone -2.76813
COL6A3 collagen, type VI, alpha 3 -2.76352
ZNF692 zinc finger protein 692 -2.75694
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.75366
HEBP1 heme binding protein 1 -2.7501
BLMH bleomycin hydrolase -2.74962
PFAS phosphoribosylformylglycinamidine synthase -2.7446
NPM3 nucleophosmin/nucleoplasmin 3 -2.74331
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.74275
RAD54L RAD54-like (S. cerevisiae) -2.73515
MANSC1 MANSC domain containing 1 -2.73473
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.73037
TERT telomerase reverse transcriptase -2.72906
KLHDC4 kelch domain containing 4 -2.72731
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.72649
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.71934
TBC1D16 TBC1 domain family, member 16 -2.70156
DENND2D DENN/MADD domain containing 2D -2.69886
AMT aminomethyltransferase -2.68712
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.68209
BAX BCL2-associated X protein -2.67809
BBS1 Bardet-Biedl syndrome 1 -2.67395
ELP5 elongator acetyltransferase complex subunit 5 -2.66459
TIMELESS timeless circadian clock -2.65266
DAPL1 death associated protein-like 1 -2.64574
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.6454
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.64197
QTRT1 queuine tRNA-ribosyltransferase 1 -2.63947
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.63885
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.62936
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.62511
RUVBL2 RuvB-like AAA ATPase 2 -2.62018
DMAC2L distal membrane arm assembly component 2 like -2.61847
FLRT1 fibronectin leucine rich transmembrane protein 1 -2.61788
ARID5B AT rich interactive domain 5B (MRF1-like) -2.61127
SCARB1 scavenger receptor class B, member 1 -2.60827
MRPS2 mitochondrial ribosomal protein S2 -2.60759
RBM15B RNA binding motif protein 15B -2.60463
ECH1 enoyl CoA hydratase 1, peroxisomal -2.59997
MXRA5 matrix-remodelling associated 5 -2.59012
SKIC8 SKI8 subunit of superkiller complex -2.5894
MTG1 mitochondrial ribosome-associated GTPase 1 -2.58799
PCP4 Purkinje cell protein 4 -2.58401
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -2.58321
GCDH glutaryl-CoA dehydrogenase -2.58167
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.5739
KIF18B kinesin family member 18B -2.56697
MYCBP MYC binding protein -2.56376
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.55454
WWOX WW domain containing oxidoreductase -2.54305
NUP93 nucleoporin 93kDa -2.53386
MST1R macrophage stimulating 1 receptor -2.53166
PDZRN3 PDZ domain containing ring finger 3 -2.52465
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.51565
KIF11 kinesin family member 11 -2.50442
YBX2 Y box binding protein 2 -2.49587
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.47842
NPY5R neuropeptide Y receptor Y5 -2.47709
COMMD10 COMM domain containing 10 -2.46375
SNRPA small nuclear ribonucleoprotein polypeptide A -2.45879
CRYL1 crystallin, lambda 1 -2.45079
NKX2-2 NK2 homeobox 2 -2.44831
PLK1 polo-like kinase 1 -2.44258
NHLRC2 NHL repeat containing 2 -2.44223
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.44141
CTPS1 CTP synthase 1 -2.43453
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.43363
CEP55 centrosomal protein 55kDa -2.43288
CNN1 calponin 1, basic, smooth muscle -2.43104
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.42484
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.42416
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.4239
MTERF3 mitochondrial transcription termination factor 3 -2.42181
LMNB1 lamin B1 -2.41823
A1CF APOBEC1 complementation factor -2.41023
TROAP trophinin associated protein -2.40904
TCEAL4 transcription elongation factor A (SII)-like 4 -2.40877
BZW2 basic leucine zipper and W2 domains 2 -2.40834
FOCAD focadhesin -2.40762
AHCY adenosylhomocysteinase -2.40109
GAA glucosidase, alpha; acid -2.38873
R3HDM2 R3H domain containing 2 -2.38764
NCAPD2 non-SMC condensin I complex, subunit D2 -2.38685
NCAPH non-SMC condensin I complex, subunit H -2.38615
NFIL3 nuclear factor, interleukin 3 regulated -2.37254
ATP5ME ATP synthase membrane subunit e -2.37227
HACD1 3-hydroxyacyl-CoA dehydratase 1 -2.3711
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.369
NUDCD3 NudC domain containing 3 -2.36797
E2F5 E2F transcription factor 5, p130-binding -2.36438
SCCPDH saccharopine dehydrogenase (putative) -2.35048
CRTAP cartilage associated protein -2.34583
NLRP4 NLR family, pyrin domain containing 4 -2.3313
ACOX2 acyl-CoA oxidase 2, branched chain -2.32066
ISOC2 isochorismatase domain containing 2 -2.31648
RABL3 RAB, member of RAS oncogene family-like 3 -2.31478
STMN1 stathmin 1 -2.31339
GFUS GDP-L-fucose synthase -2.31226
HEMK1 HemK methyltransferase family member 1 -2.31195
ESD esterase D -2.31064
MXD3 MAX dimerization protein 3 -2.30236
PGAP2 post-GPI attachment to proteins 2 -2.29975
MACROD1 MACRO domain containing 1 -2.29781
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -2.29774
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.2965
ZNF318 zinc finger protein 318 -2.29559
STXBP2 syntaxin binding protein 2 -2.29262
ZNF83 zinc finger protein 83 -2.29242
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.28778
CD99 CD99 molecule -2.28097
IFRD2 interferon-related developmental regulator 2 -2.28044
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.27367
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.27235
CTBP1 C-terminal binding protein 1 -2.27038
MECR mitochondrial trans-2-enoyl-CoA reductase -2.26715
COL1A2 collagen, type I, alpha 2 -2.26477
TXNRD3 thioredoxin reductase 3 -2.26047
RAP1GAP2 RAP1 GTPase activating protein 2 -2.25675
MYO5C myosin VC -2.25421
MAPK9 mitogen-activated protein kinase 9 -2.25001
SPDEF SAM pointed domain containing ETS transcription factor -2.24323
MGMT O-6-methylguanine-DNA methyltransferase -2.23906
GYG2 glycogenin 2 -2.22427
ACP6 acid phosphatase 6, lysophosphatidic -2.22358
DCK deoxycytidine kinase -2.22256
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.21799
EXOSC8 exosome component 8 -2.20926
DYNC2I1 dynein 2 intermediate chain 1 -2.20848
KCTD11 potassium channel tetramerization domain containing 11 -2.20801
NCOR1 nuclear receptor corepressor 1 -2.208
COPS7B COP9 signalosome subunit 7B -2.2072
ELAC2 elaC ribonuclease Z 2 -2.20653
FAIM Fas apoptotic inhibitory molecule -2.20402
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.19151
TPM1 tropomyosin 1 (alpha) -2.19039
RFC3 replication factor C (activator 1) 3, 38kDa -2.1896
SPDL1 spindle apparatus coiled-coil protein 1 -2.18548
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.18404
GLT8D1 glycosyltransferase 8 domain containing 1 -2.17952
MIS18A MIS18 kinetochore protein A -2.17537
ZNF239 zinc finger protein 239 -2.17232
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.1685
MSRB2 methionine sulfoxide reductase B2 -2.1675
ACTA2 actin, alpha 2, smooth muscle, aorta -2.16457
NSD1 nuclear receptor binding SET domain protein 1 -2.16102
TFB1M transcription factor B1, mitochondrial -2.16096
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.15952
STAU2 staufen double-stranded RNA binding protein 2 -2.15596
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.15546
DHFR dihydrofolate reductase -2.15438
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.15084
TFDP1 transcription factor Dp-1 -2.14809
TLE2 transducin-like enhancer of split 2 -2.14441
ACVR2B activin A receptor, type IIB -2.14267
MTMR11 myotubularin related protein 11 -2.13939
CHD3 chromodomain helicase DNA binding protein 3 -2.13441
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.13356
RGL2 ral guanine nucleotide dissociation stimulator-like 2 -2.13135
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.13058
PNKP polynucleotide kinase 3'-phosphatase -2.13038
CBR4 carbonyl reductase 4 -2.12998
ATP5F1D ATP synthase F1 subunit delta -2.12631
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.12555
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.12443
DOCK1 dedicator of cytokinesis 1 -2.12184
GTF3A general transcription factor IIIA -2.11942
COQ9 coenzyme Q9 -2.1189
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.11192
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.1111
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.1108
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.10948
PDIA4 protein disulfide isomerase family A, member 4 -2.10779
PCCA propionyl CoA carboxylase, alpha polypeptide -2.10551
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.1043
PHC1 polyhomeotic homolog 1 (Drosophila) -2.10308
SOAT2 sterol O-acyltransferase 2 -2.09879
CHEK2 checkpoint kinase 2 -2.09409
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.09125
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.09097
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.09043
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.08805
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.08563
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.08236
PRDM5 PR domain containing 5 -2.08208
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.08001
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.07977
PRPF8 pre-mRNA processing factor 8 -2.07657
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.07636
MAGED4B melanoma antigen family D4B -2.07577
MYG1 MYG1 exonuclease -2.07119
TUBG1 tubulin, gamma 1 -2.07022
PCYOX1L prenylcysteine oxidase 1 like -2.06973
EBNA1BP2 EBNA1 binding protein 2 -2.06862
TTLL1 tubulin tyrosine ligase-like family member 1 -2.06794
CDCA8 cell division cycle associated 8 -2.06591
AUH AU RNA binding protein/enoyl-CoA hydratase -2.06188
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.05945
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -2.05808
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.05425
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 -2.05161
USP11 ubiquitin specific peptidase 11 -2.04755
RPA3 replication protein A3, 14kDa -2.04598
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.0411
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.03907
ATXN10 ataxin 10 -2.03658
PPA2 pyrophosphatase (inorganic) 2 -2.03252
FBXO5 F-box protein 5 -2.03009
ADH6 alcohol dehydrogenase 6 (class V) -2.02947
ZNF260 zinc finger protein 260 -2.02375
MKS1 Meckel syndrome, type 1 -2.02374
RNF130 ring finger protein 130 -2.02308
COA3 cytochrome c oxidase assembly factor 3 -2.02302
MRPL57 mitochondrial ribosomal protein L57 -2.02263
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.01844
ASGR1 asialoglycoprotein receptor 1 -2.01818
SPG11 spastic paraplegia 11 (autosomal recessive) -2.0178
PACS2 phosphofurin acidic cluster sorting protein 2 -2.01654
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.01514
APOH apolipoprotein H (beta-2-glycoprotein I) -2.01274
ISOC1 isochorismatase domain containing 1 -2.0076
PGAM4 phosphoglycerate mutase family member 4 -2.00739
ATP5MF ATP synthase membrane subunit f -2.0006