CRCGN014_HEPG2_3H:A03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN014_HEPG2_3H:A03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.40944
LCN2 lipocalin 2 5.51845
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.3929
GSTZ1 glutathione S-transferase zeta 1 4.5128
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.03308
STK10 serine/threonine kinase 10 3.64713
TIAM1 T-cell lymphoma invasion and metastasis 1 3.38116
KIF5C kinesin family member 5C 3.12951
RPL39L ribosomal protein L39-like 3.04362
CHMP6 charged multivesicular body protein 6 3.04328
MEST mesoderm specific transcript 2.89254
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.887
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.77786
SAA2 serum amyloid A2 2.708
MAMLD1 mastermind-like domain containing 1 2.65039
MMP2 matrix metallopeptidase 2 2.52723
LOC122526780 uncharacterized LOC122526780 2.38405
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.30287
SHB Src homology 2 domain containing adaptor protein B 2.25665
NOSIP nitric oxide synthase interacting protein 2.13362
RAB21 RAB21, member RAS oncogene family 2.08571
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.0772
INAVA innate immunity activator 2.03049

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.40833
CD320 CD320 molecule -4.20901
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.96972
ZMIZ1 zinc finger, MIZ-type containing 1 -3.41856
OXA1L oxidase (cytochrome c) assembly 1-like -3.36186
MRPS16 mitochondrial ribosomal protein S16 -2.96324
HEATR1 HEAT repeat containing 1 -2.72585
GNAS GNAS complex locus -2.58082
CCNH cyclin H -2.56057
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.5017
COG7 component of oligomeric golgi complex 7 -2.29381
TLCD3A TLC domain containing 3A -2.22276
TRAP1 TNF receptor-associated protein 1 -2.13623
CSK c-src tyrosine kinase -2.03251