CRCGN014_HEPG2_3H:A04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN014_HEPG2_3H:A04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.42936
MAP7 microtubule-associated protein 7 4.4702
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.19305
AMDHD2 amidohydrolase domain containing 2 4.09443
MAMLD1 mastermind-like domain containing 1 4.02423
CHMP6 charged multivesicular body protein 6 3.49654
CIAO3 cytosolic iron-sulfur assembly component 3 3.45639
CXCL2 chemokine (C-X-C motif) ligand 2 3.24044
PRKCH protein kinase C, eta 3.17525
GPATCH8 G patch domain containing 8 3.14509
SFTPB surfactant protein B 3.12158
MEST mesoderm specific transcript 2.9372
PEX11A peroxisomal biogenesis factor 11 alpha 2.74883
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.68952
ATP11B ATPase, class VI, type 11B 2.6155
CCDC85B coiled-coil domain containing 85B 2.55211
STIMATE STIM activating enhancer 2.53104
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.47942
KIF14 kinesin family member 14 2.46168
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.44521
STAP2 signal transducing adaptor family member 2 2.41404
TIAM1 T-cell lymphoma invasion and metastasis 1 2.38817
STXBP2 syntaxin binding protein 2 2.29277
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.06936
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.00166

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -4.51016
OXA1L oxidase (cytochrome c) assembly 1-like -4.40411
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.55894
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.40318
THAP11 THAP domain containing 11 -3.23701
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.1637
NRIP1 nuclear receptor interacting protein 1 -3.13144
GTPBP8 GTP-binding protein 8 (putative) -2.51942
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.40501
HMOX1 heme oxygenase 1 -2.39066
ZNF274 zinc finger protein 274 -2.30282
HLA-DMA major histocompatibility complex, class II, DM alpha -2.21097