CRCGN014_HEPG2_3H:A05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 20.68 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

241 genes differentially expressed following the CRCGN014_HEPG2_3H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 7.78746
PPARG peroxisome proliferator-activated receptor gamma 7.3753
E2F2 E2F transcription factor 2 6.74203
PRR15L proline rich 15-like 5.75293
CXCL2 chemokine (C-X-C motif) ligand 2 5.14051
MINDY1 MINDY lysine 48 deubiquitinase 1 5.12775
BZW2 basic leucine zipper and W2 domains 2 4.91775
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.89652
GSTZ1 glutathione S-transferase zeta 1 4.56579
PMM2 phosphomannomutase 2 4.49059
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.37216
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.21462
CCDC85B coiled-coil domain containing 85B 4.15303
PLS1 plastin 1 3.81237
VGLL4 vestigial-like family member 4 3.6312
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.54261
FZD7 frizzled class receptor 7 3.39051
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.38819
MOK MOK protein kinase 3.30149
ZNF589 zinc finger protein 589 3.29434
NNT nicotinamide nucleotide transhydrogenase 3.24611
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.18463
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.08852
MEST mesoderm specific transcript 2.94267
CYCS cytochrome c, somatic 2.9072
NT5DC2 5'-nucleotidase domain containing 2 2.89658
CREG1 cellular repressor of E1A-stimulated genes 1 2.78282
PLSCR3 phospholipid scramblase 3 2.7798
RRAGA Ras-related GTP binding A 2.77946
AMDHD2 amidohydrolase domain containing 2 2.75074
WDTC1 WD and tetratricopeptide repeats 1 2.73234
SSBP2 single-stranded DNA binding protein 2 2.71131
SCRN1 secernin 1 2.69759
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.6913
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.69085
CDX4 caudal type homeobox 4 2.62793
PGM5 phosphoglucomutase 5 2.6034
CREB1 cAMP responsive element binding protein 1 2.5517
TSPAN6 tetraspanin 6 2.54557
AMELY amelogenin, Y-linked 2.54249
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.51519
RCVRN recoverin 2.46843
GHRH growth hormone releasing hormone 2.43384
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.38626
PRDM5 PR domain containing 5 2.37025
TMEM74B transmembrane protein 74B 2.34366
SIGLEC9 sialic acid binding Ig-like lectin 9 2.33783
CTSL cathepsin L 2.32391
CARMIL1 capping protein regulator and myosin 1 linker 1 2.3228
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.3224
ASXL3 additional sex combs like transcriptional regulator 3 2.32179
RXFP3 relaxin/insulin-like family peptide receptor 3 2.32021
NPDC1 neural proliferation, differentiation and control, 1 2.31718
EGF epidermal growth factor 2.3124
ARHGAP28 Rho GTPase activating protein 28 2.31105
DCC DCC netrin 1 receptor 2.30631
LMOD1 leiomodin 1 (smooth muscle) 2.30441
CHRM5 cholinergic receptor, muscarinic 5 2.28975
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.28674
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.28653
FN3K fructosamine 3 kinase 2.28411
HOXB8 homeobox B8 2.28348
GATA2 GATA binding protein 2 2.28181
MCHR1 melanin-concentrating hormone receptor 1 2.27493
ACKR2 atypical chemokine receptor 2 2.26827
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 2.26406
GADD45G growth arrest and DNA-damage-inducible, gamma 2.25589
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.2469
FSTL4 follistatin-like 4 2.24604
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.2404
POU3F3 POU class 3 homeobox 3 2.24033
CALCOCO1 calcium binding and coiled-coil domain 1 2.23824
HPSE2 heparanase 2 (inactive) 2.23659
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.2358
FBXO40 F-box protein 40 2.23437
EYA3 EYA transcriptional coactivator and phosphatase 3 2.23237
MELK maternal embryonic leucine zipper kinase 2.23133
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.22713
AQP6 aquaporin 6, kidney specific 2.22237
SPATA31A3 SPATA31 subfamily A, member 3 2.22223
SKIC8 SKI8 subunit of superkiller complex 2.22172
INHA inhibin, alpha 2.21536
IL5 interleukin 5 2.21406
KLHDC3 kelch domain containing 3 2.21054
VAMP7 vesicle-associated membrane protein 7 2.20968
ALAS1 5'-aminolevulinate synthase 1 2.20856
MCOLN1 mucolipin 1 2.193
HRC histidine rich calcium binding protein 2.18978
MAGEC3 melanoma antigen family C3 2.18811
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.18695
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.18047
NEUROD4 neuronal differentiation 4 2.1742
EFNA2 ephrin-A2 2.17042
CDC37 cell division cycle 37 2.16948
SYNGAP1 synaptic Ras GTPase activating protein 1 2.16678
PCDHB1 protocadherin beta 1 2.16327
KAT6A K(lysine) acetyltransferase 6A 2.14947
CCL7 chemokine (C-C motif) ligand 7 2.14741
TAC4 tachykinin 4 (hemokinin) 2.14559
AMHR2 anti-Mullerian hormone receptor, type II 2.14531
CA14 carbonic anhydrase XIV 2.14511
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.14435
CCKAR cholecystokinin A receptor 2.14167
EGR1 early growth response 1 2.14157
TACR3 tachykinin receptor 3 2.13974
FGF6 fibroblast growth factor 6 2.1374
ADRB1 adrenoceptor beta 1 2.13578
CBX7 chromobox homolog 7 2.13322
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.13261
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.12173
RPL3L ribosomal protein L3-like 2.11571
ANO1 anoctamin 1, calcium activated chloride channel 2.1152
DDB1 damage-specific DNA binding protein 1, 127kDa 2.1138
OGN osteoglycin 2.11162
FKBP8 FK506 binding protein 8, 38kDa 2.11054
IDO1 indoleamine 2,3-dioxygenase 1 2.11046
PLA2G2F phospholipase A2, group IIF 2.10653
LHFPL2 lipoma HMGIC fusion partner-like 2 2.10626
CLDN9 claudin 9 2.10426
TNIP1 TNFAIP3 interacting protein 1 2.10101
PITX3 paired-like homeodomain 3 2.09953
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.09628
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.09357
TDRKH tudor and KH domain containing 2.09173
OMP olfactory marker protein 2.08584
DTX2 deltex 2, E3 ubiquitin ligase 2.08388
BLCAP bladder cancer associated protein 2.08239
ZBTB18 zinc finger and BTB domain containing 18 2.081
UGP2 UDP-glucose pyrophosphorylase 2 2.07884
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.07509
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.07317
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.06907
GLRA1 glycine receptor, alpha 1 2.06864
GLT8D2 glycosyltransferase 8 domain containing 2 2.06761
ZIC4 Zic family member 4 2.06596
CPED1 cadherin-like and PC-esterase domain containing 1 2.06545
BTBD2 BTB (POZ) domain containing 2 2.06388
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.06302
PDE7B phosphodiesterase 7B 2.05984
FGF8 fibroblast growth factor 8 (androgen-induced) 2.05949
TBX5 T-box 5 2.05803
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.05563
PDE11A phosphodiesterase 11A 2.05131
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.04874
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.04769
KISS1 KiSS-1 metastasis-suppressor 2.04512
FOXI1 forkhead box I1 2.04394
DENND2B DENN domain containing 2B 2.0421
OXCT1 3-oxoacid CoA transferase 1 2.04079
NTN1 netrin 1 2.03958
RPL29 ribosomal protein L29 2.03912
PSG3 pregnancy specific beta-1-glycoprotein 3 2.0376
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.03556
GPR68 G protein-coupled receptor 68 2.03262
MC3R melanocortin 3 receptor 2.03132
LALBA lactalbumin, alpha- 2.03086
MTNR1B melatonin receptor 1B 2.03086
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.02682
CSN1S1 casein alpha s1 2.02191
DRD5 dopamine receptor D5 2.01842
TAS2R9 taste receptor, type 2, member 9 2.01646
IL13 interleukin 13 2.01392
TRIP10 thyroid hormone receptor interactor 10 2.01382
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.01244
HOXB1 homeobox B1 2.00906
IL3 interleukin 3 2.00903
SSTR4 somatostatin receptor 4 2.00601
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.00399
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.00382

decreased expression

Symbol Name Standardized Value
RPN1 ribophorin I -6.06277
FASTKD5 FAST kinase domains 5 -5.5365
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.15595
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.94087
SPAG4 sperm associated antigen 4 -4.9155
SCAND1 SCAN domain containing 1 -4.89718
CCNH cyclin H -4.11718
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.92077
FOS FBJ murine osteosarcoma viral oncogene homolog -3.64458
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.58679
BPHL biphenyl hydrolase-like (serine hydrolase) -3.49109
CAB39 calcium binding protein 39 -3.43394
HSPB1 heat shock 27kDa protein 1 -3.33455
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.07776
SMNDC1 survival motor neuron domain containing 1 -3.04061
PECR peroxisomal trans-2-enoyl-CoA reductase -2.88895
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.87974
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.85676
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.83824
DDB2 damage-specific DNA binding protein 2, 48kDa -2.83521
EAPP E2F-associated phosphoprotein -2.81997
CRYZ crystallin, zeta (quinone reductase) -2.80072
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.72129
RGS2 regulator of G-protein signaling 2 -2.71898
NGRN neugrin, neurite outgrowth associated -2.71638
NRIP1 nuclear receptor interacting protein 1 -2.70168
ACAA1 acetyl-CoA acyltransferase 1 -2.67549
EBNA1BP2 EBNA1 binding protein 2 -2.6606
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.6573
PRCP prolylcarboxypeptidase (angiotensinase C) -2.6509
ANKRD10 ankyrin repeat domain 10 -2.60734
PLK1 polo-like kinase 1 -2.59876
TMEM97 transmembrane protein 97 -2.58959
SCCPDH saccharopine dehydrogenase (putative) -2.56061
TCTN1 tectonic family member 1 -2.55226
GRWD1 glutamate-rich WD repeat containing 1 -2.53493
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.53132
SARAF store-operated calcium entry-associated regulatory factor -2.49935
LRRC41 leucine rich repeat containing 41 -2.49055
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.4897
HMOX1 heme oxygenase 1 -2.48569
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.48216
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.4815
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.47405
BOLA2B bolA family member 2B -2.45315
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.40054
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.38327
SLC35F2 solute carrier family 35, member F2 -2.33854
UBE2C ubiquitin-conjugating enzyme E2C -2.33678
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.27905
APOE apolipoprotein E -2.25003
NUP93 nucleoporin 93kDa -2.22984
NUP85 nucleoporin 85kDa -2.22553
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.22251
SUMF2 sulfatase modifying factor 2 -2.22218
TAOK1 TAO kinase 1 -2.19822
HLA-DMA major histocompatibility complex, class II, DM alpha -2.19675
NDFIP1 Nedd4 family interacting protein 1 -2.16767
TBPL1 TBP-like 1 -2.15369
SQOR sulfide quinone oxidoreductase -2.15365
MSMO1 methylsterol monooxygenase 1 -2.14087
AHR aryl hydrocarbon receptor -2.1309
USP22 ubiquitin specific peptidase 22 -2.12436
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.11453
TOMM34 translocase of outer mitochondrial membrane 34 -2.0825
VAT1 vesicle amine transport 1 -2.07683
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.06745
PRPF4 pre-mRNA processing factor 4 -2.03536
SLIRP SRA stem-loop interacting RNA binding protein -2.03225
AXIN1 axin 1 -2.02389
SNRPG small nuclear ribonucleoprotein polypeptide G -2.01442
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.01007