CRCGN014_HEPG2_3H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description picloram, technical grade 41.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN014_HEPG2_3H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.492
ANO1 anoctamin 1, calcium activated chloride channel 5.08531
PMM2 phosphomannomutase 2 4.95465
ADGRE5 adhesion G protein-coupled receptor E5 4.83717
COG4 component of oligomeric golgi complex 4 4.1068
CXCL2 chemokine (C-X-C motif) ligand 2 4.10058
PNKP polynucleotide kinase 3'-phosphatase 3.55712
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.54749
NT5DC2 5'-nucleotidase domain containing 2 3.47864
MKNK1 MAP kinase interacting serine/threonine kinase 1 3.40529
MAP7 microtubule-associated protein 7 3.34682
CCDC86 coiled-coil domain containing 86 3.19942
VGLL4 vestigial-like family member 4 3.10936
SFTPB surfactant protein B 2.89149
ADRB2 adrenoceptor beta 2, surface 2.76953
SYNGR3 synaptogyrin 3 2.59599
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.57319
NENF neudesin neurotrophic factor 2.50963
TXNL4B thioredoxin-like 4B 2.48736
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.46798
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.4647
CDK6 cyclin-dependent kinase 6 2.43694
RPL39L ribosomal protein L39-like 2.42718
PRKCH protein kinase C, eta 2.40391
ABHD4 abhydrolase domain containing 4 2.32092
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.3088
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.267
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.25182
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.21748
NUP133 nucleoporin 133kDa 2.19837
RFX7 regulatory factor X, 7 2.18575
FKRP fukutin related protein 2.17993
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.17691
NIT1 nitrilase 1 2.16569
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.16054
DMTF1 cyclin D binding myb-like transcription factor 1 2.14393
CCNF cyclin F 2.13511
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.13052
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.12589
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.11144
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.09645
SLC38A10 solute carrier family 38, member 10 2.09145
ANKRD7 ankyrin repeat domain 7 2.08765
SCYL3 SCY1-like 3 (S. cerevisiae) 2.08577
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 2.07439
CD40 CD40 molecule, TNF receptor superfamily member 5 2.07409
FAM193A family with sequence similarity 193, member A 2.07269
MCOLN1 mucolipin 1 2.06503
CFHR5 complement factor H-related 5 2.05634
STXBP1 syntaxin binding protein 1 2.0532
VGLL3 vestigial-like family member 3 2.04162
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.03574
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.01684
MEN1 multiple endocrine neoplasia I 2.0144
SPO11 SPO11 meiotic protein covalently bound to DSB 2.0083
MMP27 matrix metallopeptidase 27 2.00412
EGF epidermal growth factor 2.00222
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.00049

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.67217
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.43258
CD320 CD320 molecule -4.19863
HAT1 histone acetyltransferase 1 -3.84137
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.65774
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.30019
SCAND1 SCAN domain containing 1 -3.22223
TM9SF2 transmembrane 9 superfamily member 2 -3.02589
OXA1L oxidase (cytochrome c) assembly 1-like -2.92852
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.92803
ZNF586 zinc finger protein 586 -2.87069
NGRN neugrin, neurite outgrowth associated -2.8571
ELAC2 elaC ribonuclease Z 2 -2.80911
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.80239
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.77087
NCK1 NCK adaptor protein 1 -2.70965
SLC35F2 solute carrier family 35, member F2 -2.63761
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.61335
NUP93 nucleoporin 93kDa -2.60449
EBNA1BP2 EBNA1 binding protein 2 -2.58688
CDK4 cyclin-dependent kinase 4 -2.58594
CETN2 centrin, EF-hand protein, 2 -2.56584
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.37048
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.29422
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.26521
ZC2HC1A zinc finger, C2HC-type containing 1A -2.24195
DACT1 dishevelled-binding antagonist of beta-catenin 1 -2.20464
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.20033
HSPA8 heat shock 70kDa protein 8 -2.17811
ANXA5 annexin A5 -2.168
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.14708
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.14305
BCAS2 breast carcinoma amplified sequence 2 -2.09354
TCTN1 tectonic family member 1 -2.08864
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.01545