CRCGN014_HEPG2_3H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trichlorophenoxyacetic acid 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN014_HEPG2_3H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.42151
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.09232
BACE2 beta-site APP-cleaving enzyme 2 4.78631
CXCL2 chemokine (C-X-C motif) ligand 2 4.24867
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.1075
SNAP25 synaptosomal-associated protein, 25kDa 3.9836
E2F2 E2F transcription factor 2 3.93847
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.81349
KIF20A kinesin family member 20A 3.73536
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.71498
MAP7 microtubule-associated protein 7 3.63774
LPAR2 lysophosphatidic acid receptor 2 3.45155
GPATCH8 G patch domain containing 8 3.38256
GATA3 GATA binding protein 3 3.13033
CCP110 centriolar coiled coil protein 110kDa 3.03272
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.97784
TIAM1 T-cell lymphoma invasion and metastasis 1 2.97265
GPER1 G protein-coupled estrogen receptor 1 2.94147
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.93159
TBP TATA box binding protein 2.76113
LCN2 lipocalin 2 2.63207
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.52451
NPY5R neuropeptide Y receptor Y5 2.47754
ILK integrin-linked kinase 2.46291
SAA2 serum amyloid A2 2.39208
FHL2 four and a half LIM domains 2 2.38731
F13A1 coagulation factor XIII, A1 polypeptide 2.28423
MAN2A1 mannosidase, alpha, class 2A, member 1 2.22788
ZMPSTE24 zinc metallopeptidase STE24 2.22632
UNG uracil-DNA glycosylase 2.20732
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.16738
DIPK1A divergent protein kinase domain 1A 2.14845
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.11285
LIPF lipase, gastric 2.06901
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.031
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.01132
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.00043

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.56338
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.47991
NUP93 nucleoporin 93kDa -4.98271
TUBB6 tubulin, beta 6 class V -4.81909
ZNF586 zinc finger protein 586 -4.80019
CCNB2 cyclin B2 -4.27435
LDHD lactate dehydrogenase D -4.14873
ZMIZ1 zinc finger, MIZ-type containing 1 -4.05046
TRIB3 tribbles pseudokinase 3 -4.03495
FGFR4 fibroblast growth factor receptor 4 -3.48926
NGRN neugrin, neurite outgrowth associated -3.43288
RHEB Ras homolog enriched in brain -3.37179
EDN1 endothelin 1 -3.11976
EIF5 eukaryotic translation initiation factor 5 -3.0415
OXA1L oxidase (cytochrome c) assembly 1-like -3.00502
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.8501
GSR glutathione reductase -2.65459
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.62891
CCNB1 cyclin B1 -2.53132
REPIN1 replication initiator 1 -2.45109
TXNDC9 thioredoxin domain containing 9 -2.35179
GRWD1 glutamate-rich WD repeat containing 1 -2.2529
TBC1D31 TBC1 domain family, member 31 -2.22152
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.16954
COG7 component of oligomeric golgi complex 7 -2.16947
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.14786
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.1028
CD52 CD52 molecule -2.08116
RASAL2 RAS protein activator like 2 -2.07817
TCEAL4 transcription elongation factor A (SII)-like 4 -2.04193