CRCGN014_HEPG2_3H:A08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_3H:A08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 8.29089
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.86687
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.74977
ANO1 anoctamin 1, calcium activated chloride channel 4.66075
SCCPDH saccharopine dehydrogenase (putative) 4.06786
SFTPB surfactant protein B 3.92179
FZD7 frizzled class receptor 7 3.91817
CSK c-src tyrosine kinase 3.53059
TXNL4B thioredoxin-like 4B 3.35153
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.17197
PFKL phosphofructokinase, liver 3.05886
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.00449
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.82851
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.74578
BLMH bleomycin hydrolase 2.72472
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.7019
GPATCH8 G patch domain containing 8 2.67972
EVL Enah/Vasp-like 2.39002
PRR15L proline rich 15-like 2.34427
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.30076
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.18311
TXNRD1 thioredoxin reductase 1 2.17372
SKIC8 SKI8 subunit of superkiller complex 2.00238

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.20725
LDHD lactate dehydrogenase D -4.98053
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.8106
TLCD3A TLC domain containing 3A -4.71025
PCNA proliferating cell nuclear antigen -4.64302
TCEAL4 transcription elongation factor A (SII)-like 4 -3.53134
PUF60 poly-U binding splicing factor 60KDa -3.48563
EIF5 eukaryotic translation initiation factor 5 -3.28062
ZMIZ1 zinc finger, MIZ-type containing 1 -3.17839
RAI14 retinoic acid induced 14 -2.95778
PTPRK protein tyrosine phosphatase, receptor type, K -2.71321
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.55776
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.47118
MAPK13 mitogen-activated protein kinase 13 -2.38006
RNPS1 RNA binding protein S1, serine-rich domain -2.26603