| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | cimetidine 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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78 genes differentially expressed following the CRCGN014_HEPG2_3H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBQLN2 | ubiquilin 2 | 6.61125 |
| EPHB2 | EPH receptor B2 | 3.96837 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 3.6534 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 3.59265 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.4178 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | 3.27553 |
| SFTPB | surfactant protein B | 3.04617 |
| NIT1 | nitrilase 1 | 3.00616 |
| TEX10 | testis expressed 10 | 2.90619 |
| KIF20A | kinesin family member 20A | 2.76727 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.72479 |
| TRIM13 | tripartite motif containing 13 | 2.69493 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 2.69067 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.68018 |
| CHMP6 | charged multivesicular body protein 6 | 2.66206 |
| TPD52L2 | tumor protein D52-like 2 | 2.62669 |
| STX4 | syntaxin 4 | 2.57699 |
| MEST | mesoderm specific transcript | 2.5106 |
| GATA2 | GATA binding protein 2 | 2.50233 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.46976 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 2.4595 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 2.36575 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 2.3415 |
| VPS45 | vacuolar protein sorting 45 homolog (S. cerevisiae) | 2.31122 |
| LAP3 | leucine aminopeptidase 3 | 2.25843 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.24403 |
| PTK2 | protein tyrosine kinase 2 | 2.23965 |
| TYW2 | tRNA wybutosine-synthesizing protein 2 | 2.22579 |
| BAD | BCL2-associated agonist of cell death | 2.19348 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.18725 |
| KLHDC2 | kelch domain containing 2 | 2.17905 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 2.16663 |
| MOK | MOK protein kinase | 2.15806 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.12908 |
| GRB10 | growth factor receptor-bound protein 10 | 2.0344 |
| PMM2 | phosphomannomutase 2 | 2.01241 |
| DROSHA | drosha, ribonuclease type III | 2.01175 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VAT1 | vesicle amine transport 1 | -8.21484 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -6.41632 |
| DNM1L | dynamin 1-like | -6.38708 |
| CDC20 | cell division cycle 20 | -4.5271 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.96907 |
| GOLT1B | golgi transport 1B | -3.87556 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -3.11379 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.09194 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.95789 |
| SCAND1 | SCAN domain containing 1 | -2.82219 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.7944 |
| LDHD | lactate dehydrogenase D | -2.74815 |
| SLC35F2 | solute carrier family 35, member F2 | -2.74609 |
| ETNK1 | ethanolamine kinase 1 | -2.66888 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.60924 |
| NGRN | neugrin, neurite outgrowth associated | -2.58387 |
| GLOD4 | glyoxalase domain containing 4 | -2.56179 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.55431 |
| GLDC | glycine dehydrogenase (decarboxylating) | -2.52094 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.49649 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -2.45936 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.43676 |
| TLR4 | toll-like receptor 4 | -2.37412 |
| CCNB2 | cyclin B2 | -2.31399 |
| WASHC4 | WASH complex subunit 4 | -2.30443 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.24573 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.23518 |
| AEBP1 | AE binding protein 1 | -2.22588 |
| CLTB | clathrin, light chain B | -2.22511 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.2032 |
| ANXA7 | annexin A7 | -2.19648 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -2.14523 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -2.11252 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.10568 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.08993 |
| CAPRIN2 | caprin family member 2 | -2.08991 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | -2.07729 |
| NDC1 | NDC1 transmembrane nucleoporin | -2.06211 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.03683 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.03468 |
| IMPA1 | inositol(myo)-1(or 4)-monophosphatase 1 | -2.0195 |
