CRCGN014_HEPG2_3H:A12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 40.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN014_HEPG2_3H:A12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.80201
CBR3 carbonyl reductase 3 5.19233
CCL2 chemokine (C-C motif) ligand 2 4.59976
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.42307
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.36783
ANO1 anoctamin 1, calcium activated chloride channel 3.84258
EPHA3 EPH receptor A3 3.67306
CYCS cytochrome c, somatic 3.66005
JADE2 jade family PHD finger 2 3.31932
DYNLT3 dynein, light chain, Tctex-type 3 3.15275
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.10127
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.87451
DIPK1A divergent protein kinase domain 1A 2.752
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.74002
PRKCH protein kinase C, eta 2.71883
TIMP2 TIMP metallopeptidase inhibitor 2 2.57291
IQGAP1 IQ motif containing GTPase activating protein 1 2.51347
LCN2 lipocalin 2 2.45856
SHB Src homology 2 domain containing adaptor protein B 2.41724
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.41272
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.40847
STAP2 signal transducing adaptor family member 2 2.39766
NFIL3 nuclear factor, interleukin 3 regulated 2.36094
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.33576
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.31165
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.29962
KIF14 kinesin family member 14 2.28415
TIAM1 T-cell lymphoma invasion and metastasis 1 2.23087
PRKCD protein kinase C, delta 2.22764
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.15627
FCHO1 FCH domain only 1 2.12635
TAS2R10 taste receptor, type 2, member 10 2.07865
RNF113A ring finger protein 113A 2.03369
ADAMTSL2 ADAMTS-like 2 2.02589
TRIM13 tripartite motif containing 13 2.01548
UBE2A ubiquitin-conjugating enzyme E2A 2.00696

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.11604
PCCB propionyl CoA carboxylase, beta polypeptide -4.34106
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.20759
DNM1L dynamin 1-like -4.08046
CCNB2 cyclin B2 -3.68259
BLCAP bladder cancer associated protein -3.61574
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.39419
ADI1 acireductone dioxygenase 1 -3.27928
CDC20 cell division cycle 20 -3.03262
SLC35F2 solute carrier family 35, member F2 -2.99085
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.9712
ISOC1 isochorismatase domain containing 1 -2.93152
PECR peroxisomal trans-2-enoyl-CoA reductase -2.70701
TXNDC9 thioredoxin domain containing 9 -2.61391
CD320 CD320 molecule -2.60054
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.44334
IFRD2 interferon-related developmental regulator 2 -2.42732
ZNF586 zinc finger protein 586 -2.42637
CLTB clathrin, light chain B -2.32151
NGRN neugrin, neurite outgrowth associated -2.28786
AKAP8 A kinase (PRKA) anchor protein 8 -2.12845
APOE apolipoprotein E -2.12541
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.07714
DDB2 damage-specific DNA binding protein 2, 48kDa -2.072
HMOX1 heme oxygenase 1 -2.02258
IFT88 intraflagellar transport 88 -2.00041