CRCGN014_HEPG2_3H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyltoluamide 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN014_HEPG2_3H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.1382
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.09542
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.9323
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.63078
PNKP polynucleotide kinase 3'-phosphatase 3.59618
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.57176
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.51232
SAA2 serum amyloid A2 3.44953
PMM2 phosphomannomutase 2 3.23289
BAX BCL2-associated X protein 3.10814
CEMIP2 cell migration inducing hyaluronidase 2 3.09382
H2BC12 H2B clustered histone 12 3.01298
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.88555
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.81937
MEST mesoderm specific transcript 2.68834
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.67037
CCNA1 cyclin A1 2.64834
GPER1 G protein-coupled estrogen receptor 1 2.5602
PTK2 protein tyrosine kinase 2 2.46087
PLD3 phospholipase D family, member 3 2.42161
TRIM13 tripartite motif containing 13 2.37895
CREG1 cellular repressor of E1A-stimulated genes 1 2.22306
NUP133 nucleoporin 133kDa 2.19061
LCMT2 leucine carboxyl methyltransferase 2 2.17004
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.13641
SSBP2 single-stranded DNA binding protein 2 2.12659
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.11202
SNPH syntaphilin 2.09616
KCTD5 potassium channel tetramerization domain containing 5 2.05695
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.03356
DPY19L4 dpy-19-like 4 (C. elegans) 2.02905
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.01178

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.56154
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.62027
CD320 CD320 molecule -5.39812
SLC35F2 solute carrier family 35, member F2 -5.22153
GNAS GNAS complex locus -5.19539
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.98671
PCNA proliferating cell nuclear antigen -4.5765
CCDC86 coiled-coil domain containing 86 -4.56403
CCNB2 cyclin B2 -4.026
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.95355
RFC2 replication factor C (activator 1) 2, 40kDa -3.86553
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.52516
ADI1 acireductone dioxygenase 1 -3.44612
EIF5 eukaryotic translation initiation factor 5 -3.11304
CSK c-src tyrosine kinase -3.10928
ETFB electron-transfer-flavoprotein, beta polypeptide -2.92685
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.56663
CAB39 calcium binding protein 39 -2.51627
GCAT glycine C-acetyltransferase -2.50268
SLC6A16 solute carrier family 6, member 16 -2.39544
SOD1 superoxide dismutase 1, soluble -2.29172
GDF15 growth differentiation factor 15 -2.28778
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 -2.28191
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.23696
GLOD4 glyoxalase domain containing 4 -2.1699
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.16607
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.16398
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.13938
POU4F1 POU class 4 homeobox 1 -2.11749
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.10376
ZNF442 zinc finger protein 442 -2.09267
MMP25 matrix metallopeptidase 25 -2.08577
KIF5A kinesin family member 5A -2.08401
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.0675
APRT adenine phosphoribosyltransferase -2.05312
GDF7 growth differentiation factor 7 -2.04586
CMC2 C-x(9)-C motif containing 2 -2.04312
ZNF721 zinc finger protein 721 -2.02762
OR2H1 olfactory receptor, family 2, subfamily H, member 1 -2.02402
OR1A1 olfactory receptor, family 1, subfamily A, member 1 -2.02052
LDHD lactate dehydrogenase D -2.01671
BPHL biphenyl hydrolase-like (serine hydrolase) -2.01229
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.01131
AASS aminoadipate-semialdehyde synthase -2.00945
PPCDC phosphopantothenoylcysteine decarboxylase -2.00836