CRCGN014_HEPG2_3H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorpropamide 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN014_HEPG2_3H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 7.03647
CBR3 carbonyl reductase 3 4.5106
MKNK1 MAP kinase interacting serine/threonine kinase 1 3.81986
PRAF2 PRA1 domain family, member 2 3.70052
UBQLN2 ubiquilin 2 3.68652
STIMATE STIM activating enhancer 3.64225
DIPK1A divergent protein kinase domain 1A 3.32026
GPATCH8 G patch domain containing 8 3.25566
KIF20A kinesin family member 20A 3.21567
LPAR2 lysophosphatidic acid receptor 2 3.03738
MMP1 matrix metallopeptidase 1 2.99508
GPC1 glypican 1 2.86925
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.76195
NENF neudesin neurotrophic factor 2.67022
NT5DC2 5'-nucleotidase domain containing 2 2.66714
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.63313
NXN nucleoredoxin 2.62466
CCP110 centriolar coiled coil protein 110kDa 2.60912
TERT telomerase reverse transcriptase 2.47604
USP6NL USP6 N-terminal like 2.46216
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.41965
BAD BCL2-associated agonist of cell death 2.3499
KLHL9 kelch-like family member 9 2.32894
COG2 component of oligomeric golgi complex 2 2.31344
GPER1 G protein-coupled estrogen receptor 1 2.25813
HOXA10 homeobox A10 2.2309
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.21456
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.2018
C1QL1 complement component 1, q subcomponent-like 1 2.17382
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.15808
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.11878
GALE UDP-galactose-4-epimerase 2.10193
ADAR adenosine deaminase, RNA-specific 2.08227
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.06407
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.02659

decreased expression

Symbol Name Standardized Value
CCNH cyclin H -5.5677
VAT1 vesicle amine transport 1 -5.42959
CDC20 cell division cycle 20 -4.23398
OXA1L oxidase (cytochrome c) assembly 1-like -4.04943
DSG2 desmoglein 2 -3.89738
PCNA proliferating cell nuclear antigen -3.72576
MAPK13 mitogen-activated protein kinase 13 -3.55342
TXNRD1 thioredoxin reductase 1 -3.5141
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.43819
ZNF586 zinc finger protein 586 -3.41487
ZDHHC6 zinc finger, DHHC-type containing 6 -3.33379
WDR7 WD repeat domain 7 -3.205
RPIA ribose 5-phosphate isomerase A -3.1251
HAT1 histone acetyltransferase 1 -3.03827
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.97619
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.75252
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.68981
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.67859
EIF5 eukaryotic translation initiation factor 5 -2.6345
MPC2 mitochondrial pyruvate carrier 2 -2.5272
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.4683
PRCP prolylcarboxypeptidase (angiotensinase C) -2.4333
ACAA1 acetyl-CoA acyltransferase 1 -2.35711
TRIB2 tribbles pseudokinase 2 -2.35586
NUP93 nucleoporin 93kDa -2.31344
BICC1 BicC family RNA binding protein 1 -2.30876
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.28768
CAB39 calcium binding protein 39 -2.28185
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.28183
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.27139
TLR4 toll-like receptor 4 -2.25112
MBTD1 mbt domain containing 1 -2.23642
SGK1 serum/glucocorticoid regulated kinase 1 -2.19824
USP53 ubiquitin specific peptidase 53 -2.15553
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.11978
OSGIN2 oxidative stress induced growth inhibitor family member 2 -2.10517
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.10346
KANSL1L KAT8 regulatory NSL complex subunit 1-like -2.09899
NAXD NAD(P)HX dehydratase -2.07756
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.06077
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 -2.04846
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.03866
SCAND1 SCAN domain containing 1 -2.03429
FOXJ3 forkhead box J3 -2.02277
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02017