CRCGN014_HEPG2_3H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitrosomorpholine 20.91 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN014_HEPG2_3H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.06739
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.01489
ZNF589 zinc finger protein 589 4.84039
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.54259
PPARG peroxisome proliferator-activated receptor gamma 4.41072
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.84739
TIAM1 T-cell lymphoma invasion and metastasis 1 3.84196
SKIC8 SKI8 subunit of superkiller complex 3.81459
LOC122526780 uncharacterized LOC122526780 3.67638
CHN1 chimerin 1 3.66419
MAP7 microtubule-associated protein 7 3.60198
UBQLN2 ubiquilin 2 3.56744
TREM1 triggering receptor expressed on myeloid cells 1 3.45716
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.36509
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.22172
TBP TATA box binding protein 3.1034
GPER1 G protein-coupled estrogen receptor 1 3.10019
SNAP25 synaptosomal-associated protein, 25kDa 3.07774
KDM5A lysine (K)-specific demethylase 5A 2.70607
SSBP2 single-stranded DNA binding protein 2 2.64227
TXNL4B thioredoxin-like 4B 2.57858
MEST mesoderm specific transcript 2.49437
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.46732
PLSCR3 phospholipid scramblase 3 2.45692
CHMP6 charged multivesicular body protein 6 2.38964
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.17537
ICAM1 intercellular adhesion molecule 1 2.16442
SFTPB surfactant protein B 2.1613
MRPL16 mitochondrial ribosomal protein L16 2.12226
EXOSC9 exosome component 9 2.04346
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.02615

decreased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase -4.71218
CDC25B cell division cycle 25B -4.51717
CCNB1 cyclin B1 -4.17619
CDC20 cell division cycle 20 -4.02894
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.44755
LYPLA1 lysophospholipase I -3.20877
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.20467
TLR4 toll-like receptor 4 -3.20237
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.74472
TCTN1 tectonic family member 1 -2.54158
TM9SF2 transmembrane 9 superfamily member 2 -2.53897
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.53144
RGS2 regulator of G-protein signaling 2 -2.43957
CCNB2 cyclin B2 -2.40961
TOR1A torsin family 1, member A (torsin A) -2.38551
JRKL JRK-like -2.21117
ALCAM activated leukocyte cell adhesion molecule -2.14679
AVIL advillin -2.04291