CRCGN014_HEPG2_3H:A22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalamide 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN014_HEPG2_3H:A22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.02651
STK10 serine/threonine kinase 10 4.84781
PRR15L proline rich 15-like 4.69853
CYCS cytochrome c, somatic 4.21552
CEP57 centrosomal protein 57kDa 3.80505
ATP11B ATPase, class VI, type 11B 3.49588
GPER1 G protein-coupled estrogen receptor 1 3.28012
GPATCH8 G patch domain containing 8 3.26679
EPN2 epsin 2 3.21308
PIH1D1 PIH1 domain containing 1 3.12639
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.09232
TXNL4B thioredoxin-like 4B 2.92211
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.84359
ZFP36 ZFP36 ring finger protein 2.60075
C2CD5 C2 calcium-dependent domain containing 5 2.36073
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.22099
MAP7 microtubule-associated protein 7 2.20703
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.10364
KIF14 kinesin family member 14 2.08317
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.06602
TMEM165 transmembrane protein 165 2.05333
KIF20A kinesin family member 20A 2.02026

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.06843
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.79955
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.09237
MAPK13 mitogen-activated protein kinase 13 -4.01123
TLR4 toll-like receptor 4 -3.93564
LDHD lactate dehydrogenase D -3.90793
OXA1L oxidase (cytochrome c) assembly 1-like -3.77358
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.54033
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.00193
TLCD3A TLC domain containing 3A -2.76616
DERA deoxyribose-phosphate aldolase (putative) -2.73572
SOAT2 sterol O-acyltransferase 2 -2.52291
MPC2 mitochondrial pyruvate carrier 2 -2.46923
HLA-DMA major histocompatibility complex, class II, DM alpha -2.32942
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.32043
PRR7 proline rich 7 (synaptic) -2.14469
ETNPPL ethanolamine-phosphate phospho-lyase -2.08343
TP53I3 tumor protein p53 inducible protein 3 -2.06488
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.00285